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| 1 | Prognostic factors in patients with advanced cholangiocarcinoma: Role of surgery, chemotherapy and body mass index显示文摘AIM: To study the factors that may affect survival of cholangiocarcinoma in Lebanon. METHODS: A retrospective review of the medical records of 55 patients diagnosed with cholangio- carcinoma at the American University of Beirut between 1990 and 2005 was conducted. Univariate and multivariate analyses were performed to determine the impact of surgery, chemotherapy, body mass index, bilirubin level and other factors on survival. RESULTS: The median survival of all patients was 8.57 mo (0.03-105.2). Univariate analysis showed that low bilirubin level (< 10 mg/dL), radical surgery and chemotherapy administration were significantly associated with better survival (P = 0.012, 0.038 and 0.038, respectively). In subgroup analysis on patients who had no surgery, chemotherapy administration prolonged median survival significantly (17.0 mo vs 3.5 mo, P = 0.001). Multivariate analysis identifiedonly low bilirubin level < 10 mg/dL and chemotherapy administration as independent predictors associated with better survival (P < 0.05). CONCLUSION: Our data show that palliative and postoperative chemotherapy as well as a bilirubin level < 10 mg/dL are independent predictors of a significant increase in survival in patients with cholangiocarcinoma. | Mirna H Farhat Ali I Shamseddine Ayman N Tawil Ghina Berjawi Charif Sidani Wael Shamseddeen Kassem A Barada | 2008 | World Journal of Gastroenterology2008，14，20： | 9 |
| 2 | Effect of mucin production on survival in colorectal cancer:A case-control study显示文摘AIM: To investigate the impact of mucin production on prognosis in colorectal cancer, in terms of overall survival (OS) and time to disease progression (TTP) in patients with mucinous compared to those with non-mucinous colorectal cancer (NMCRC), matched for age, gender, and tumor stage.METHODS: Thirty five patients with mucinous colorectal cancer (MCRC) were matched for age, gender, and tumor stage with 35 controls having NMCRC. OS and TTP were compared among 4 groups divided according to mucin content: group A (50%-75% mucin), group B (75%-100% mucin), group C or controls (< 50% mucin). Group D consisted of all patients with tumors having < 75% mucin (controls and groups A together).RESULTS: Median survival in MCRC and NMCRC groups was 46.2 and 112.9 mo, respectively (P = 0.26). OS in groups A and B was 70.1 and 32.8 mo (P = 0.46), and in groups B and D was 32.8 and 70.1 mo, respectively (P = 0.143). TTP in MCRC and NMCRC was 50.17 and 44.77 mo, respectively (P = 0.795). TTP in groups A, B, and D was 70.1, 24.8, and 65.5 mo, respectively. Twenty-eight percent of patients with MCRC had poorly differentiated adenocarcinoma versus 8.6% in NMCRC patients (P = 0.028).CONCLUSION: MCRC is associated with a non-significant decrease in median survival and TTP, particularlywhen mucin content is > 75% of tumor volume. However, it tends to be more poorly differentiated. A larger study matching for stage and grade is needed. | Mirna H Farhat Kassem A Barada Ayman N Tawil Doha M Itani Hassan A Hatoum Ali I Shamseddine | 2008 | World Journal of Gastroenterology2008，14，45： | 6 |
| 3 | A simulated evolution approach to task matcging and scheduling in heterogeneous computing environments显示文摘 | Barada H Sait S M Baig N | 2002 | Engineering Applications of Artificial Intelligence2002，15，9： | 1 |
| 4 | Testicular salvage and age-related delay in the presentation of testicular torsion显示文摘 | Barada J H Weingarten J L Cromie W J | 1989 | J Urol1989，142，3： | 1 |
| 5 | Testicular salvage and age-related delay in the presentation of testicular torsion显示文摘 | Barada J H Weingarten J L Cromie W J | 1989 | J Urol1989，142，3： | 1 |
| 6 | Clinical guidelines panel on erectile dysfunction: summary report on the treatment of organic erectile dysfunction显示文摘 | Montague D K Barada J H Belker A M | 1996 | J Urol1996，156，6： | 1 |
| 7 | Testicular salvage and age-related delay in the presentation of testicular torsion显示文摘 | Barada J H Weingarten J L Cromie W J | 1989 | J Urol1989，142，： | 1 |
| 8 | Testicular salvage and age-related delay in the presentation of testicular torsion显示文摘 | Barada J H Weingarten J L Cromie W J | 1989 | J Urol1989，142，3： | 1 |
| 9 | Elec trocautery-induced localized colonic injury elicits in- creased levels of pro-inflammatory cytokines in small bowel and decreases jejunal alanine absorption显示文摘 | BARADA K MOURAD F H NOURSI B | 2015 | Cytokine2015，71，1： | 1 |
| 10 | Localized colonic inflammation increases eytokine lev- els in distant small intestinal segments in the rat显示文摘 | BARADA K A MOURAD F H SAWAH S I | 2006 | Life Sci2006，79，21： | 1 |
| 11 | Up-regulation of nerve growth factor and interleukin- 10 in inflamed and non-inflamed intestinal segments in rats with experimental colitis显示文摘 | BARADA K A MOURAD F H SAWAH S I | 2007 | Cytokine2007，37，3： | 1 |
| 12 | Inter- play between nitric oxide and vasoactive intestinal poly-peptide in inducing fluid secretion in rat jejunum显示文摘 | Mourad F H Barada K A Abdel-Malak N | 2003 | The Journal of Physiology2003，550，3： | 1 |
| 13 | Inhibitory effect of experimental colitis on fluid absorption in rat jejunum:role of the enteric nervous system,VIP,and nitric oxide显示文摘 | Mourad F H Barada K A Bou Rached N A | | 0，，02： | 1 |
| 14 | Polarization recording in photoinduced chiral material for optical storage 显示文摘 | Barada D Fukuda T Sumimura H | 2007 | Appl Phys Ⅰ2007，46，： | 1 |
| 15 | Atorvastatin-induced severe gastric ulceration: A case report显示文摘A 41-year-old man presented with severe gastric ulceration 3 mo after beginning treatment with atorvastatin 20 mg once daily for hypercholesterolemia. The patient was not taking any ulcerogenic drugs and had no evidence of Helicobacter pylori infection. Proton pump inhibitor therapy was initiated and atorvastatin was replaced by simvastatin with complete resolution of gastrointestinal symptoms. To our knowledge, this is the first report of atorvastatin-induced gastric ulceration,which should be looked for in patients who develop abdominal pain while on this drug. | Ihab I El-Hajj Fadi H Mourad Nina S Shabb Kassem A Barada | 2005 | World Journal of Gastroenterology2005，11，20： | 0 |
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