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| 1 | Prognostic factors in patients with advanced cholangiocarcinoma: Role of surgery, chemotherapy and body mass index显示文摘AIM: To study the factors that may affect survival of cholangiocarcinoma in Lebanon. METHODS: A retrospective review of the medical records of 55 patients diagnosed with cholangio- carcinoma at the American University of Beirut between 1990 and 2005 was conducted. Univariate and multivariate analyses were performed to determine the impact of surgery, chemotherapy, body mass index, bilirubin level and other factors on survival. RESULTS: The median survival of all patients was 8.57 mo (0.03-105.2). Univariate analysis showed that low bilirubin level (< 10 mg/dL), radical surgery and chemotherapy administration were significantly associated with better survival (P = 0.012, 0.038 and 0.038, respectively). In subgroup analysis on patients who had no surgery, chemotherapy administration prolonged median survival significantly (17.0 mo vs 3.5 mo, P = 0.001). Multivariate analysis identifiedonly low bilirubin level < 10 mg/dL and chemotherapy administration as independent predictors associated with better survival (P < 0.05). CONCLUSION: Our data show that palliative and postoperative chemotherapy as well as a bilirubin level < 10 mg/dL are independent predictors of a significant increase in survival in patients with cholangiocarcinoma. | Mirna H Farhat Ali I Shamseddine Ayman N Tawil Ghina Berjawi Charif Sidani Wael Shamseddeen Kassem A Barada | 2008 | World Journal of Gastroenterology2008，14，20： | 9 |
| 2 | Effect of mucin production on survival in colorectal cancer:A case-control study显示文摘AIM: To investigate the impact of mucin production on prognosis in colorectal cancer, in terms of overall survival (OS) and time to disease progression (TTP) in patients with mucinous compared to those with non-mucinous colorectal cancer (NMCRC), matched for age, gender, and tumor stage.METHODS: Thirty five patients with mucinous colorectal cancer (MCRC) were matched for age, gender, and tumor stage with 35 controls having NMCRC. OS and TTP were compared among 4 groups divided according to mucin content: group A (50%-75% mucin), group B (75%-100% mucin), group C or controls (< 50% mucin). Group D consisted of all patients with tumors having < 75% mucin (controls and groups A together).RESULTS: Median survival in MCRC and NMCRC groups was 46.2 and 112.9 mo, respectively (P = 0.26). OS in groups A and B was 70.1 and 32.8 mo (P = 0.46), and in groups B and D was 32.8 and 70.1 mo, respectively (P = 0.143). TTP in MCRC and NMCRC was 50.17 and 44.77 mo, respectively (P = 0.795). TTP in groups A, B, and D was 70.1, 24.8, and 65.5 mo, respectively. Twenty-eight percent of patients with MCRC had poorly differentiated adenocarcinoma versus 8.6% in NMCRC patients (P = 0.028).CONCLUSION: MCRC is associated with a non-significant decrease in median survival and TTP, particularlywhen mucin content is > 75% of tumor volume. However, it tends to be more poorly differentiated. A larger study matching for stage and grade is needed. | Mirna H Farhat Kassem A Barada Ayman N Tawil Doha M Itani Hassan A Hatoum Ali I Shamseddine | 2008 | World Journal of Gastroenterology2008，14，45： | 6 |
| 3 | Aspirin use for primary prophylaxis: Adverse outcomes in non-variceal upper gastrointestinal bleeding显示文摘AIM: To compare outcomes of patients with nonvariceal upper gastrointestinal bleeding(NVUGIB) taking aspirin for primary prophylaxis to those not taking it.METHODS: Patients not known to have any vascular disease(coronary artery or cerebrovascular disease) who were admitted to the American University of Beirut Medical Center between 1993 and 2010 with NVUGIB were included. The frequencies of in-hospital mortality, re-bleeding, severe bleeding, need for surgery or embolization, and of a composite outcome defined as the occurrence of any of the 4 bleeding related adverse outcomes were compared between patients receiving aspirin and those on no antithrombotics. We also compared frequency of in hospital complications and length of hospital stay between the two groups.RESULTS: Of 357 eligible patients, 94 were on aspirin and 263 patients were on no antithrombotics(controlgroup). Patients in the aspirin group were older, the mean age was 58 years in controls and 67 years in the aspirin group(P < 0.001). Patients in the aspirin group had significantly more co-morbidities, including diabetes mellitus and hypertension [25(27%) vs 31(112%) and44(47%) vs 74(28%) respectively,(P = 0.001)], as well as dyslipidemia [21(22%) vs 16(6%), P < 0.0001).Smoking was more frequent in the aspirin group [34(41%) vs 60(27%), P = 0.02)]. The frequencies of endoscopic therapy and surgery were similar in both groups. Patients who were on aspirin had lower inhospital mortality rates(2.1% vs 13.7%, P = 0.002),shorter hospital stay(4.9 d vs 7 d, P = 0.01), and fewer composite outcomes(10.6% vs 24%, P = 0.01). The frequencies of in-hospital complications and re-bleeding were similar in the two groups.CONCLUSION: Patients who present with NVUGIB while receiving aspirin for primary prophylaxis had fewer adverse outcomes. Thus aspirin may have a protective effect beyond its cardiovascular benefits. | Karina M Souk Hani M Tamim Hussein A Abu Daya Don C Rockey Kassem A Barada | 2016 | World Journal of Gastrointestinal Surgery2016，8，7： | 3 |
| 4 | Inflammatory bowel disease in rats:Bacterial and chemical interaction显示文摘AIM: To develop a novel model of colitis in rats, using a combination of iodoacetamide and enteropathogenic E. coli (EPEC), and to elucidate the pathophysiologic processes implicated in the development of ulcerative colitis (UC). METHODS: Male Sprague-Dawley rats (n = 158) were inoculated intrarectally on a weekly basis with 4 different combinations: (a) 1% methylcellulose (MC), (b) 100 μL of 6% iodoacetamide (IA) in 1% MC, (c) 200 μL containing 4 × 108 colony factor units (CFU) of EPEC, and (d) combined treatment of (IA) followed by bacteria (B) after 2 d. Thirty days post treatment, each of the four groups was divided into two subgroups; the inoculation was stopped for one subgroup and the other subgroup continued with biweekly inoculation until the end of the experiment. Colitis was evaluated by the clinical course of the disease, the macroscopic and microscopic alterations, activity of myeloperoxidase (MPO), and by TNF-α gene expression. RESULTS: Findings indicative of UC were seen in the combined treatment (IA + B) as well as the IA conti-nued treatment groups: the animals showed slow rate of increase in body weight, diarrhea, bloody stools, high colonic ulcer score, as well as histological altera- tions characteristic of UC, with an extensive inflamma- tory reaction. During the course of the experiment, the MPO activity was consistently elevated and the TNF-α gene expression was upregulated compared to the control animals. CONCLUSION: The experimental ulcerative colitis model used in the present study resembles, to a great extent, the human disease. It is reproducible with characteristics indicative of chronicity. | Inaya Abdallah Hajj Hussein Rania Tohme Kassem Barada Mostafa Hassan Mostafa Jean-Noel Freund Rosalyn A Jurjus Walid Karam Abdo Jurjus | 2008 | World Journal of Gastroenterology2008，14，25： | 2 |
| 5 | Achieving treatment optimization with Viagra in patients with ED 显示文摘 | McCullough AR Barada JH Fawzy A | 2002 | Urology2002，60，22： | 1 |
| 6 | Advanced glycation endproducts in peripheral nerve in Type 2 diabetes with neuropathy显示文摘 | Misur I Zarkovic K Barada A | 2004 | Acta Diabetol2004，41，4： | 1 |
| 7 | Advanced glycation endprod- ucts in peripheral nerve in type 2 diabetes with neuropathy 显示文摘 | Misur I Zarkovic K Barada A | 2004 | Acta Diabetol2004，41，4： | 1 |
| 8 | The effect of olive oil supplementation on human platelet function, serum cholesterolrelated variables and plasma fibrinogen concentrations 显示文摘 | BARADAS M A CHRISTOFIDES J A JEREMY J Y | 1990 | Nutrition Research1990，10，4： | 1 |
| 9 | Clinical guidelines panel on erectile dysfunction: summary report on the treatment of organic erectile dysfunction显示文摘 | Montague D K Barada J H Belker A M | 1996 | J Urol1996，156，6： | 1 |
| 10 | Achieving treatment optimization with sildenafil citrate in patients with erectile dysfunction显示文摘 | McCullough AR Barada JH Fawzy A | 2002 | Urology2002，，： | 1 |
| 11 | Advanced glycation end products in peripheral nerve in type 2 diabetes with neuropathy显示文摘 | Misur I Zarkovic K Barada A | 2004 | Acta Diabetol2004，41，1： | 1 |
| 12 | The effect of olive oil supplementation on human platelet function, serum choles- terol related variables and plasma fibrinogen concentrations显示文摘 | BARADAS M A CHRISTOFIDES J A JEREMY J Y | 1990 | Nutrition Research1990，10，4： | 1 |
| 13 | Advanced glycation endproducts in peripheral nerve in type 2 diabetes with neuropathy显示文摘 | Misur I ZarkovieK Barada A | 2004 | Acta Diabetol2004，41，： | 1 |
| 14 | Antibodies to Sm in patients with systemic lupus erythematosus: Correlation of Sm antibody titers with disease activity and other laboratory parameters 显示文摘 | Barada F A Jr Andrews B S Davis J S 4th | 1981 | Arthritis Rheum1981，24，10： | 1 |
| 15 | Localized colonic inflammation increases eytokine lev- els in distant small intestinal segments in the rat显示文摘 | BARADA K A MOURAD F H SAWAH S I | 2006 | Life Sci2006，79，21： | 1 |
| 16 | Up-regulation of nerve growth factor and interleukin- 10 in inflamed and non-inflamed intestinal segments in rats with experimental colitis显示文摘 | BARADA K A MOURAD F H SAWAH S I | 2007 | Cytokine2007，37，3： | 1 |
| 17 | Giant sporadic fundic gland polyp:Endoscopic and endosonographic features and management显示文摘Fundic gland polyps are the most common gastric polyps. They are usually small in size, sporadic and asymptomatic. We present a case of giant fundic gland polyp. Our case is particular because of the clinica presentation, the endoscopic and endosonographic documented findings, and the treatment otpions followed. | Ihab I El Hajj Mohamad Hawchar Assaad Soweid Karim Maasri Ayman Tawil Kassem A Barada | 2008 | World Journal of Gastroenterology2008，14，42： | 1 |
| 18 | Advanced glycation endproducts in peripheral nerve in type 2 diabetes with neuropathy显示文摘 | Misur I Zarkovic K Barada A | 2004 | Acta Diabetol2004，41，4： | 1 |
| 19 | Antibodies to Sm in patients with systemic lupus erythematosus correlation of Sm antibody titers with disease activity and other laboratory parameters显示文摘 | Barada F A Andrews B S Davis J S | 1981 | Arthritis Rheum1981，24，8： | 1 |
| 20 | A review of the current status of topical treatments for premature ejaculation显示文摘 | Morales A Barada J Wyllie MG | | 0，，03： | 1 |
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