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| 1 | Overlapping expression of microRNAs in human embryonic colon and colorectal cancer显示文摘MicroRNAs (miRNAs ) 为调整房间区别并且维持干细胞的 pluripotent 状态是必要的。尽管特定的 miRNAs 的 dysregulation 与癌症的某些类型被联系了,到日期,没有证据连接了 miRNA 表示在胚胎并且肿瘤纸巾。我们在人的胚胎的结肠组织,并且在 colorectal 癌症估计了成熟 miRNAs 的表示并且配对正常结肠组织。重叠 miRNA 表示在胚胎的结肠的 mucosa 和 colorectal 癌症之间被检测。我们发现了 miR-17-92 聚类,调整在两个盒子中的房间增长并且它的目标, E2F1,在人的冒号开发和结肠的 carcinogenesis 展出表示的一个类似的模式。在 situ,杂交在地窟祖先分隔空间证实了 miR-17-5p 的表示的高水平。我们断定 miRNA 小径在胚胎的开发和结肠的上皮的肿瘤的转变起一个主要作用。 | Mariano Monzo Alfons Navarro Eva Bandres Rosa Artells Isabel Moreno Bemat Gel Rafael Ibeas Jose Moreno Francisco Martinez Tania Diaz Antonio Martinez Olga Balague Jesus Garcia-Foncillas | 2008 | Cell Research2008，18，8： | 32 |
| 2 | Identification of colorectal cancer metastasis markers by an angiogenesis-related cytokine-antibody array显示文摘AIM:To investigate the angiogenesis-related protein expression profile characterizing metastatic colorectal cancer (mCRC) with the aim of identifying prognostic markers.METHODS:The expression of 44 angiogenesissecreted factors was measured by a novel cytokine antibody array methodology.The study evaluated vascular endothelial growth factor (VEGF) and its soluble vascular endothelial growth factor receptor (sVEGFR)-1 protein levels by enzyme immunoassay (EIA) in a panel of 16 CRC cell lines.mRNA VEGF and VEGF-A isoforms were quantified by quantitative reverse-transcription polymerase chain reaction (Q-RT-PCR) and vascular endothelial growth factor receptor (VEGFR)-2 expression was analyzed by flow cytometry.RESULTS:Metastasis-derived CRC cell lines expressed a distinctive molecular profile as compared with those isolated from a primary tumor site.Metastatic CRC cell lines were characterized by higher expression of angiogenin-2 (Ang-2),macrophage chemoattractant proteins-3/4 (MCP-3/4),matrix metalloproteinase-1 (MMP-1),and the chemokines interferon γ inducible T cell α chemoattractant protein (I-TAC),monocyte chemoattractant protein I-309,and interleukins interleukin (IL)-2 and IL-1α,as compared to primary tumor cell lines.In contrast,primary CRC cell lines expressed higher levels of interferon γ (IFN-γ),insulin-like growth factor-1 (IGF-1),IL-6,leptin,epidermal growth factor (EGF),placental growth factor (PlGF),thrombopoietin,transforming growth factor β1 (TGF-β1) and VEGF-D,as compared with the metastatic cell lines.VEGF expression does not significantly differ according to the CRC cellular origin in normoxia.Severe hypoxia induced VEGF expression up-regulation but contrary to expectations,metastatic CRC cell lines did not respond as much as primary cell lines to the hypoxic stimulus.In CRC primary-derived cell lines,we observed a twofold increase in VEGF expression between normoxia and hypoxia as compared to metastatic cell lines.CRC cell lines express a similar pattern of VEGF isoforms (VEGF 121,VEGF 165 and VEGF 189) despite variability in VEGF expression,where the major transcript was VEGF 121.No relevant expression of VEGFR-2 was found in CRC cell lines,as compared to that of human umbilical vein endothelial cells and sVEGFR-1 expression did not depend on the CRC cellular origin.CONCLUSION:A distinct angiogenesis-related expression pattern characterizes metastatic CRC cell lines.Factors other than VEGF appear as prognostic markers and intervention targets in the metastatic CRC setting. | Ana Abajo Nerea Bitarte Ruth Zarate Valentina Boni Ines Lopez Marisol Gonzalez-Huarriz Javier Rodriguez Eva Bandres Jesus Garcia-Foncillas | 2012 | World Journal of Gastroenterology2012，18，7： | 8 |
| 3 | Xeroderma pigmentosum group D 751 polymorphism as a predictive factor in resected gastric cancer treated with chemo-radiotherapy显示文摘AIM: To evaluate the potential association of xeroderma pigmentosum group D (XPD) codon 751 variant with outcome after chemo-radiotherapy in patients with resected gastric cancer. METHODS: We used PCR-RFLP to evaluate the genetic XPD Lys751Gln polymorphisms in 44 patients with stage Ⅲ (48%) and Ⅳ (20%) gastric cancer treated with surgery following radiation therapy plus 5-fluorouracil/ leucovorin based chemotherapy. RESULTS: Statistical analysis showed that 75% (12 of 16) of relapse patients showed Lys/Lys genotype more frequently (P = 0.042). The Lys polymorphism was an independent predictor of high-risk relapse-free survival from Cox analysis (HR: 3.07, 95% CI: 1.07-8.78, P = 0.036) and Kaplan-Meir test (P = 0.027, log-rank test). CONCLUSION: XPD Lys751Gln polymorphism may be an important marker in the prediction of clinical outcome to chemo-radiotherapy in resected gastric cancer patients. | RN Zárate R F Arias E Bandres E Cubedo R Malumbres J García-Foncillas | 2006 | World Journal of Gastroenterology2006，12，37： | 7 |
| 4 | Pharmacogenomics in colorectal cancer: The first step for individualized-therapy显示文摘Interindividual differences in the toxicity and response to anticancer therapies are currently observed in practically all available treatment regimens. A goal of cancer therapy is to predict patient response and toxicity to drugs in order to facilitate the individualization of patient treatment. Identification of subgroups of patients that differ in their prognosis and response to treatment could help to identify the best available drug therapy according the genetic profile. Several mechanisms have been suggested to contribute to chemo-therapeutic drug resistance: amplification or overexpression of membrane transporters, changes in cellular proteins involved in detoxification or in DNA repair, apoptosis and activation of oncogenes or tumor suppressor genes. Colorectal cancer (CRC) is regarded as intrinsically resistant to chemotherapy. Several molecular markers predictive of CRC therapy have been included during the last decade but their results in different studies complicate their application in practical clinical. The simultaneous testing of multiple markers predictive of response could help to identify more accurately the true role of these polymorphisms in CRC therapy. This review analyzes the role of genetic variants in genes involved in the action mechanisms of the drugs used at present in colorectal cancer. | Eva Bandrés Ruth Zárate Natalia Ramirez Ana Abajo Nerea Bitarte Jesus García-Foncillas | 2007 | World Journal of Gastroenterology2007，13，44： | 4 |
| 5 | Moving forward in colorectal cancer research, what proteomics has to tell显示文摘Colorectal cancer is the third most common cancer and is highly fatal. During the last several years, research has been primarily based on the study of expression profiles using microarray technology. But now, investigators are putting into practice proteomic analyses of cancer tissues and cells to identify new diagnostic or therapeutic biomarkers for this cancer. Because the proteome reflects the state of a cell, tissue or organism more accurately, much is expected from proteomics to yield better tumor markers for disease diagnosis and therapy monitoring. This review summarizes the most relevant applications of proteomics the biomarker discovery for colorectal cancer. | Nerea Bitarte Eva Bandrés Ruth Zárate Natalia Ramirez Jesus Garcia-Foncillas | 2007 | World Journal of Gastroenterology2007，13，44： | 3 |
| 6 | microRNA-451 Regulates Macrophage Migration Inhibitory Factor Production and Proliferation of Gastrointestinal显示文摘 | Bandres E Bitarte N Arias F | 2009 | Cancer Cells2009，15，7： | 1 |
| 7 | microRNA - 451 reg- ulates macrophage migration inhibitory factor production and proliferation of gastrointestinal cancer cells 显示文摘 | Bandres E Bitarte N Arias F | 2009 | Clin Cancer Res2009，15，7： | 1 |
| 8 | Strangulated umbilical hernia in children(Burkina Faso):differences with developed countries显示文摘 | BandréE KaboréRA Sanou A | 2010 | Bull Soc Pathol Exot2010，103，2： | 1 |
| 9 | Epigenetic regulation of microRNA expression in colorectal cancer显示文摘 | BANDRES E AGIRRE X BITARTE N | 2009 | Int J Cancer2009，125，11： | 1 |
| 10 | Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues显示文摘 | Bandre s E Cubedo E Agirre X | 2006 | Mol Cancer2006，5，： | 1 |
| 11 | MicroRNA - 45! is involved in the self - renewal, tumorigenicity, and chemoresis- tance of colorectal cancer stem cells显示文摘 | BITARTE N BANDRES E BONI V | 2011 | Stem Cells2011，29，11： | 1 |
| 12 | Association between bone mineral density and polymorphisms of the VDR, ERalpha,COL1A1 and CTR genes in Spanish postmenopausal women 显示文摘 | Bandres E Pombo I Gonzalez-Huarriz M | 2005 | J Endocrinol Invest2005，28，4： | 1 |
| 13 | Oxaliplatin, irinotecan and capecitabine as first-line therapy in metastatic colorectal cancer (mCRC): a dose-finding study and pharmacogenomic analysis显示文摘 | Zarate R Rodriguez J Bandres E | 2010 | Br J Cancer2010，102，6： | 1 |
| 14 | Epigenetic regulation of microRNA expression in colorectal cancer显示文摘 | Bandres E Agime X Zarate R | 2009 | Int J Cancer2009，125，11： | 1 |
| 15 | Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression 显示文摘 | Bandres E Andion E Escalada A | 2005 | J Neurooncol2005，73，3： | 1 |
| 16 | MicroRNA-451 is involved in the self-renewal, lumorigenieity, and chemoresislanee of coloreetal cancer stem cells 显示文摘 | Bitarte N Bandres E Boni V | 2011 | Stem Cells2011，29，11： | 1 |
| 17 | Epigenetic regulation of microRNA expression in colorectal cancer显示文摘 | BANDRES E AGIRRE X BITARTE N | 2009 | International Journal of Cancer2009，125，11： | 1 |
| 18 | Identification by real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and nontumoral tissues显示文摘 | Bandres E Cubedo E Agirre X | | 0，，： | 1 |
| 19 | Helmholtz-gauss waves显示文摘 | GUTIERREZ-Vega J C BANDRES M A | 2005 | Journal of the Optical Society of America A2005，22，2： | 1 |
| 20 | TWIST1 overexpression is associated with nodal invasion and male sex in primary colorectal cancer显示文摘 | Valdes-Mora F Gomez del Pulgar T Bandres E | 2009 | Ann Surg Oncol2009，16，1： | 1 |
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