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| 1 | Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer’s disease显示文摘Aging is by far the most prominent risk factor for Alzheimer’s disease(AD),and both aging and AD are associated with apparent metabolic alterations.As developing effective therapeutic interventions to treat AD is clearly in urgent need,the impact of modulating whole-body and intracellular metabolism in preclinical models and in human patients,on disease pathogenesis,have been explored.There is also an increasing awareness of differential risk and potential targeting strategies related to biological sex,microbiome,and circadian regulation.As a major part of intracellular metabolism,mitochondrial bioenergetics,mitochondrial quality-control mechanisms,and mitochondria-linked inflammatory responses have been considered for AD therapeutic interventions.This review summarizes and highlights these efforts. | Steven N.Austad Scott Ballinger Thomas W.Buford Christy S.Carter Daniel L.Smith Jr Victor Darley-Usmar Jianhua Zhang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 2 | Age-related changes in D2 receptor binding with iodine-123-iodobenzofuran SPECT显示文摘 | Ichise M Ballinger JR Tanaka F | 1998 | J Nucl Med1998，39，9： | 1 |
| 3 | BRU59-21, a second-generation 99mTc-labeled 2-nitroimidazole for imaging hypoxia in rumors显示文摘 | Melo T Duncan J Ballinger JR | 2000 | J Nucl Med2000，41，： | 1 |
| 4 | Flux through multicellular layers of a technetium-99m-nitroimidazole for imaging hypoxia显示文摘 | Melo T Tunggal JK Ballinger JR | 2002 | Cancer Biother Radiopharm2002，17，5： | 1 |
| 5 | Imaging hypoxia in tumors 显示文摘 | Ballinger JR | 2001 | Semin Nucl Med2001，31，4： | 1 |
| 6 | Delivery of an anticancer drug and a chemosensitizer to murine breast sarcoma by intratumoral injection of sulfopropyl dextran microspheres显示文摘 | Ballinger JR Rauth AM | 2003 | J Pharm Pharmacol2003，55，8： | 1 |
| 7 | Imaging hypoxia in tumors显示文摘 | Ballinger JR | 2001 | Semin Nucl Med2001，31，4： | 1 |
| 8 | IR spectroscopic detection of Lew- is acid sites on A12 03 using adsorbed CO correlation with A1OH group removal显示文摘 | Ballinger T H Jr Yates J T | 1991 | Langmuir1991，7，12： | 1 |
| 9 | The influence of expression of P-glycoprotein on the penetration of anticancer drugs through mul- ticellular layers显示文摘 | Tunggal JK Melo T Ballinger JR | 2000 | Int J Cancer2000，86，1： | 1 |
| 10 | 99Tcm-TF for functional imaging of P-glycoprotein modulation in vivo显示文摘 | Ballinger JR | 2001 | J Clin Pharmacol2001，，： | 1 |
| 11 | Imaging inflammation with 99Tcm-labelled chemotactic peptides: analogues with reduced neutropenia 显示文摘 | Pollak A Goodbody AE Ballinger JR | 1996 | Nucl Med Commun1996，17，： | 1 |
| 12 | Imaging hypoxia in tumors显示文摘 | Ballinger JR | 2001 | Semi Nucl Med2001，31，4： | 1 |
| 13 | Influence of cell concentration in limiting the therapeutic benefit of P-gp coprotein reversal agents显示文摘 | Tunggal JK Ballinger JR Tannock IF | 1999 | Cancer1999，81，5： | 1 |
| 14 | Hypoxia in radiation-induced blood-spinal cord barrier breakdown显示文摘 | Li YQ Ballinger JR Nordal RA | 2001 | Cancer Res2001，61，8： | 1 |
| 15 | In Vitro and in Vivo Evaluation of a Technetium-99m-labeled 2-nitromidazole ( BMS181321) as a Marker of Tumor Hypoxia显示文摘 | BALLINGER JR Wan MIN KEE J RAUTH AM | 1996 | J Nucl Med1996，37，6： | 1 |
| 16 | Hypoxia in radiation-in- duced blood-spinal cord barrier breakdowm显示文摘 | Li YQ Ballinger JR Nordal RA | 2001 | Cancer Res2001，61，8： | 1 |
| 17 | BRU59-21, a Second-generation ^99mTc-labeled 2-nitromidazole for Imaging Hypoxia in Tumors显示文摘 | MELO Tricia DUCAN Jill BALLINGER JR | 2000 | J Nucl Med2000，41，1： | 1 |
| 18 | Hypoxia in radiation-inducedblood-spinal cord barrier breakdown显示文摘 | Li YQ Ballinger JR Nordal RA | 2001 | Cancer Res2001，61，8： | 1 |
| 19 | Effect of Hypoxia on the Accumulation of Technetium-99m-glucarate and Technetium-99m-gluconate by Chinese Hamstar Ovary Cells in Vitro显示文摘 | BALLINGER JR COWAN DSM BOXEN I | 1993 | J Nucl Med1993，34，2： | 1 |
| 20 | Prostate- specific antigen induction by a steroid hormone in T47D cells growing in SCID mice 显示文摘 | Kogan I Ballinger JR Redshaw R | 1998 | Breast Cancer Res Treat1998，48，1： | 1 |
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