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| 1 | Heparin resistance in severe thermal injury:a prospective cohort study显示文摘Background:Low molecular-weight heparin(LMWH)is routinely administered to burn patients for thromboprophylaxis.Some studies have reported heparin resistance,yet the mechanism(s)and prevalence have not been systematically studied.We hypothesized that nucleosomes,composed of histone structures with associated DNA released from injured tissue and activated immune cells in the form of neutrophil extracellular traps(NETs or NETosis),neutralize LMWH resulting in suboptimal anticoagulation,assessed by reduction in anti-factor Xa activity.Methods:Blood was sampled from>15%total body surface area(TBSA)burn patients receiving LMWH on days 5,10 and 14.Peak anti-factor Xa(AFXa)activity,anti-thrombin(ATIII)activity,cellfree DNA(cfDNA)levels and nucleosome levels were measured.Mixed effects regression was adjusted for multiple confounders,including injury severity and ATIII activity,and was used to test the association between nucleosomes and AFXa.Results:A total of 30 patients with severe burns were included.Mean TBSA 43%(SD 17).Twentythree(77%)patients were affected by heparin resistance(defined by AFXa activity<0.2 IU/mL).Mean peak AFXa activity across samples was 0.18 IU/mL(SD 0.11).Mean ATIII was 81.9%activity(SD 20.4).Samples taken at higher LWMH doses were found to have significantly increased AFXa activity,though the effect was not observed at all doses,at 8000 IU no samples were heparin resistant.Nucleosome levels were negatively correlated with AFXa(r=−0.29,p=0.050)consistent with the hypothesis.The final model,with peak AFXa as the response variable,was adjusted for nucleosome levels(p=0.0453),ATIII activity(p=0.0053),LMWH dose pre-sample(p=0.0049),drug given(enoxaparin or tinzaparin)(p=0.03),and other confounders including severity of injury,age,gender,time point of sample.Conclusions:Heparin resistance is a prevalent issue in severe burns.Nucleosome levels were increased post-burn,and showed an inverse association with AFXa consistent with the hypothesis that they may interfere with the anticoagulant effect of heparin in vivo and contribute to heparin resistance.Accurate monitoring of AFXa activity with appropriate therapy escalation plans are recommended with dose adjustment following severe burn injury. | Liam D Cato Benjamin Bailiff Joshua Price Christos Ermogeneous Jon Hazeldine William Lester Gillian Lowe Christopher Wearn Jonathan RB Bishop Janet M Lord Naiem Moiemen Paul Harrison | 2021 | Burns & Trauma2021，9，1： | 3 |
| 2 | Two-photon excitation and luminescence of a CaWO4 scintillator显示文摘 | MIKHAILIK V B BAILIFF I K KRAUS H RODNYI P A NINKOVIC J | 2004 | Radiat Measur2004，38，： | 1 |
| 3 | Precision robotic coating application and thickness control optimization for F-35 final finishes 显示文摘 | Seegmiller N A Bailiff J A Franks R K | 2009 | SAE International Journal of Aerospace2009，2，1： | 1 |
| 4 | Thermolumineseenee measurements of gamma-ray doses attributable to fallout from the Nevada test site using building bricks as natural dosimeters显示文摘 | HASKELL E H BAILIFF I K KENNER G H | 1994 | Health Phys1994，66，4： | 1 |
| 5 | The use of ceramics for retrospective dosimetry in the Chemobyl exclusion zone 显示文摘 | BAILIFF I K | 1995 | Radiat Meas1995，24，4： | 1 |
| 6 | ' Candidatus Mycoplasma haematoparvum' , a novel small haemotropic mycoplasma from a dog 显示文摘 | Sykes J E Ball L M Bailiff N L | 2005 | Int J Syst Evol Microbiol2005，55，1： | 1 |
| 7 | Identification of a novel hemotropic mycoplasma in a splenectomized dog with hemic neoplasia 显示文摘 | Sykes JE Bailiff NL Ball LM | 2004 | Journal of American Veterinary Association2004，224，19： | 1 |
| 8 | Candidatus Mycoplasma haematoparvum', a novel small haemotropic mycoplasma from a dog 显示文摘 | Sykes JE Ball LM Bailiff NL | 2005 | International Journal of Systematic and Evolutionary Microbiology2005，55，： | 1 |
| 9 | Heavy metal contamination of settling particles in a retention pond along the A - 17 motorway in Sologne,France显示文摘 | Lee P K Touray J C bailiff j P | 1997 | Sci Tot Environ1997，201，： | 1 |
| 10 | Identification of a novel hemotropic mycoplasma in a splenectomized dog with hemic neoplasia显示文摘 | Sykes JE Bailiff NL Ball LM | 2004 | J Am Vet Med Assoc2004，224，： | 1 |
| 11 | 'Candidatus Mycoplasma haematoparvum', a novel small haemotropic mycoplasma from a dog显示文摘 | Sykes JE Ball LM Bailiff NL | 2005 | Int J Syst Evol Microbiol2005，55，： | 1 |
| 12 | The measurement and distribution of dissolved nucleic acids in aquatic environments 显示文摘 | Karl D M Bailiff M D | 1989 | Limnology and Oceanography1989，34，3： | 1 |
| 13 | Effect of re- crystallisation on the radioactive contamination of CaWO 4 crystal scintillators 显示文摘 | Danevich F Bailiff I Kobychev V | 2011 | Nuclear Instruments and Meth- ods in Physics Research Section A: Accelerators Spec- trometers Detectors and Associated Equipment2011，631，1： | 1 |
| 14 | Use of photrasfer for the anomalous fading of thermoluminescence 显示文摘 | Bailiff I K | 1976 | Nature1976，264，： | 1 |
| 15 | Two-phonton excitation and luminescence of CaWO4scintillato显示文摘 | MIKHALIK V B BAILIFF I K KRANUS H | 2004 | RadiationMeasurements2004，38，： | 1 |
| 16 | Two-photon excitation and luminescence of a CaWO4 scintillator 显示文摘 | Mikhailik V B Bailiff I K Kraus H | 2004 | Radiat Meas2004，38，46： | 1 |
| 17 | Heavy metal contamination of settling particles in a retention pond along the A - 17 motorway in Sologne, France显示文摘 | Lee P K Touray J C bailiff j P | 1997 | Sci Tot Environ1997，201，： | 1 |
| 18 | Candidatus Mycoplasma haematoparvum, a novel small haemotropic mycoplasma from a dog显示文摘 | Sykes JE Ball LM Bailiff NL | 2005 | Int J Syst Evol Mierobiol2005，55，1： | 1 |
| 19 | Absorbed dose evaluations in retrospective dosimetry: methodological developments using quartz显示文摘 | Bailiff I K Btter-Jensen L Correcher V Delgado A Gksu H Y Jungner H Petrov S A | 2000 | Radiation Measurements2000，32，1： | 1 |
| 20 | The first international intercomparison of EPR dosimetry with teeth: first results显示文摘 | Chumk V Bailiff I Baran N | 1996 | Appl Radiat Isot1996，47，： | 1 |
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