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您的检索式：作者名="Baifeng Fu"
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| 1 | Three novel umami peptides derived from the alcohol extract of the Pacific oyster(Crassostrea gigas):identification,characterizations and interactions with T1R1/T1R3 taste receptors显示文摘Oyster(Crassostrea gigas),the main ingredient of oyster sauce,has a strong umami taste.In this study,three potential umami peptides,FLNQDEEAR(FR-9),FNKEE(FE-5),and EEFLK(EK-5),were identified and screened from the alcoholic extracts of the oyster using nano-HPLC-MS/MS analysis,i Umami-Scoring Card Method(i Umami-SCM)database and molecular docking(MD).Sensory evaluation and electronic tongue analysis were further used to confirm their tastes.The threshold of the three peptides ranged from 0.38 to 0.55 mg/m L.MD with umami receptors T1R1/T1R3 indicated that the electrostatic interaction and hydrogen bond interaction were the main forces involved.Besides,the Phe592 and Gln853 of T1R3 were the primary docking site for MD and played an important role in umami intensity.Peptides with two Glu residues at the terminus had stronger umami,especially at the C-terminus.These results contribute to the understanding of umami peptides in oysters and the interaction mechanism between umami peptides and umami receptors. | Baifeng Fu Di Wu Shuzhen Cheng Xianbing Xu Ling Zhang Lishu Wang Heshanm REl-Seedi Hanxiong Liu Ming Du | 2024 | Food Science and Human Wellness2024，13，1： | 1 |
| 2 | DISCOVERY OF TRIKETONE-QUINOXALINE HYBRIDS AS POTENT HPPD INHIBITORS USING STRUCTUREBASED DRUG DESIGN显示文摘p-Hydroxyphenylpyruvate dioxygenase(EC 1.13.11.27,HPPD)belongs to the family of Fe(II)-dependent non-heme oxygenases that occur in the majority of aerobic organisms.HPPD has proved to be a promising target in herbicide research and development.A battery of novel triketone-quinoxaline compounds has been designed using a structure-based drug design strategy and then prepared.Enzyme inhibition assays show that these synthesized derivatives possess favorable inhibition capability against Arabidopsis thaliana HPPD with IC50 values ranging from 0.317 to 0.891 mmol$L–1.Subsequently,the molecular docking results indicate that two adjacent carbonyls of the triketone moiety of the representative compound 2-(2,3-dimethyl-8-(o-tolyl)quinoxaline-6-carbonyl)-3-hydroxycyclohex-2-en-1-one(7d)engage in chelation with the ferrous ion of A.thaliana HPPD in a bidentate pose,and its quinoxaline scaffold forms two sets of parallelπ-stacking interaction between two phenylalanine residues(Phe424 and Phe381).In addition,the extended phenyl group also interacts with Phe392 in aπ-πstacking way.This study indicates that triketone-quinoxaline is a promising scaffold for discovering HPPD inhibitors with substantially increased potency,providing insight into the molecular design of new herbicides. | Baifeng ZHENG Yaochao YAN Can FU Guangyi HUANG Long ZHAO Qiong CHEN Renyu QU Guangfu YANG | 2022 | Frontiers of Agricultural Science and Engineering2022，9，1： | 0 |
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