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| 1 | Reversed-phase fused-core HPLC modeling of peptides显示文摘Different fused-core stationary phase chemistries(C18,Amide,Phenyl-hexyl and Peptide ES-C18) were used for the analysis of 21 structurally representative model peptides.In addition,the effects of the mobile phase composition(ACN or MeOH as organic modifier;formic acid or acetic acid,as acidifying component) on the column selectivity,peak shape and overall chromatographic performance were evaluated.The RP-amide column,combined with a formic acid-acetonitrile based gradient system,performed as best.A peptide reversed-phase retention model is proposed,consisting of 5 variables:log SumAA,log Sv,clog P,log nHDon and log nHAcc.Quantitative structure-retention relationship(QSRR) models were constructed for 16 different chromatographic systems.The accuracy of this peptide retention model was demonstrated by the comparison between predicted and experimentally obtained retention times,explaining on average 86% of the variability.Moreover,using an external set of 5 validation peptides,the predictive power of the model was also demonstrated.This peptide retention model includes the novel in-silico calculated amino acid descriptor,AA,which was calculated from log P,3D-MoRSE,RDF and WHIM descriptors. | Matthias D'Hondt Bert Gevaert Sofie Stalmans Sylvia Van Dorpe Evelien Wynendaele Kathelijne Peremans Christian Burvenich Bart De Spiegeleer | 2013 | Journal of Pharmaceutical Analysis2013，3，2： | 3 |
| 2 | Bovine somatotropin and acute escherichia coli mastitis显示文摘 | BURVENICH | 1988 | Ann Med Vet1988，132，： | 2 |
| 3 | Biodistfibution and planar gamma camera imaging of 123I- and 131I-labeled F(ab)2 and Fab fragments of monoclonal antibody 14C5 in nude mice bearing an A549 lung tumor显示文摘 | Burvenich I J Schoonoogbe S Blanckaert P | 2007 | Nuel Med Biol2007，34，3： | 1 |
| 4 | Dynamic contour tonometry (DCT) versus non - contact tonometry(NCT ) : a comparison study显示文摘 | Burvenich H Burvenich E Vincent C | 2005 | Bull Soc Beige Opbtalmol2005，，298： | 1 |
| 5 | Interaction between the respiratory burst activity of neutrophil leukocytes and experimentall induced Escherichia coli mastitis in cows显示文摘 | Hcyneman R C Burvenich R Vercauteren | 1990 | Dairy Science1990，73，： | 1 |
| 6 | Role of endotoxin and TNF-alpha in the pathogenesis of experimentally induced coliform mastitis inperiparturient cows显示文摘 | Hoeben D Burvenich C | 2000 | J Dairy Res2000，67，4： | 1 |
| 7 | In vitro and in vivo targeting properties of iodine-123-or iodine- 131-labeled monoclonal antibody 14C5 in a non-small cell lung cancer and colon carcinoma model 显示文摘 | Burvenich I Schoonooghe S Cornelissen B | 2005 | Clin Cancer Res2005，11，20： | 1 |
| 8 | Increased surface expression of CD11b receptors on polymorphonuclear leukocytes is not sufficient to sustain phagocytosis during Escherichia coli mastitis in early postpartum dairy cows显示文摘 | Dosogne H Burvenich C Van Werven T | 1997 | Vet Immunol Immunopathol1997，60，： | 1 |
| 9 | Evaluation of the role of endotoxin and cortisol on modulation of CD18 adhesion receptors in cows with mastitis caused by Escherichia coli显示文摘 | Roets E Burvenich C Diez-Fraile A | 1999 | Vet Res1999，60，5： | 1 |
| 10 | Evaluation of the role of endotoxin and cortisol on modulation of CD18 adhesion receptors in cows with mastitis caused by Escherichia coli显示文摘 | Burvenich C Diez-Fraile A | 1999 | Am J Vet Res1999，60，5： | 1 |
| 11 | Cumulativephysiological events influence the inflammatory response of thebovine udder to Escherichia coli infections during the transitionperiod显示文摘 | Burvenich C Bannerman D D Lippolis D | 2007 | Journal of Dairy Science2007，，90： | 1 |
| 12 | Effect of intramammary infu- sion of colchicine on mammary blood flow in lactating goats 显示文摘 | BURVENICH C PEETERS G | 1980 | J Anim Physiol Anim Nutr1980，44，15： | 1 |
| 13 | Risk evaluation of impurities in topical excipients:The acetol case显示文摘Pharmaceutical excipients for topical use may contain impurities,which are often neglected from a toxicity qualification viewpoint.The possible impurities in the most frequently used topical excipients were evaluated in-silico for their toxicity hazard.Acetol,an impurity likely present in different topical pharmaceutical excipients such as propylene glycol and glycerol,was withheld for the evaluation of its health risk after dermal exposure.An ex-vivo in-vitro permeation study using human skin in a Franz Diffusion Cell set-up and GC as quantification methodology showed a significant skin penetration with an overall K_p value of 1.82 × 10^(-3)cm/h.Using these data,limit specifications after application of a dermal pharmaceutical product were estimated.Based on the TTC approach of Cramer class I substances,i.e.1800 μg/(day·person),the toxicity-qualified specification limits of acetol in topical excipients were calculated to be 90 μg/mL and 180 μg/mL for propylene glycol and glycerol,respectively. | Jente Boonen Lieselotte Veryser Lien Taevernier Nathalie Roche Kathelijne Peremans Christian Burvenich Bart De Spiegeleer | 2014 | Journal of Pharmaceutical Analysis2014，4，5： | 1 |
| 14 | Diapedesis across mammary epithelium reduces phagocytic and oxidative burst of bovine neutrophils显示文摘 | Smits E Burvenich C Albert J | 1999 | Veterin Immunol Immunopathol1999，68，3： | 1 |
| 15 | Cumulative Physi-ological Events Influence the Inflammatory Response of the Bovine Udderto Escherichia coli Infections During the Transition Period显示文摘 | BURVENICH C BANNERMAN D D LIPPOLIS J | 2007 | Journal ofDairy Science2007，90，： | 1 |
| 16 | Role of endotoxin and TNF -alpha in the pathogenesis of experimentally induced coliform mastitis in periparturient cows 显示文摘 | HOEBEN D BURVENICH C | 2000 | J Dairy Res2000，67，4： | 1 |
| 17 | Viability of milk neutrophils and severity of bovine coliform mastitis显示文摘 | MEHRZAD J DUCHATEAU L BURVENICH C | 2004 | J Dairy Sci2004，87，12： | 1 |
| 18 | Apoptosis of bovine neutrophils following diapedesis through a monolayer of endothelial and mammary epithelial cells显示文摘 | Van Oostveldt K Paape M J Burvenich C | 2002 | J Dairy Sci2002，85，： | 1 |
| 19 | Simultaneous flow cytometric measurement of phagocytotic and oxidative burst activity of polymorphonuclear leukocytes in whole bovine blood 显示文摘 | Burvenich C Heyneman R | 1997 | Vet Immuol Immunopathol1997，56，： | 1 |
| 20 | Natural defense mechanisms of the lactating and dry mammary gland显示文摘 | Burvenich C | 1995 | Proceedings 3rd International Mastitis Seminar Telephone Aviva Israel 19951995，81，15： | 1 |
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