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| 1 | Heart failure with preserved ejection fraction in the elderly: pathophysiology, diagnostic and therapeutic approach显示文摘Heart failure with preserved ejection fraction(HFpEF)is a clinical syndrome characterized by symptoms and sings of heart failure with elevated left ventricular filling pressures at rest or during exercise.It is the most common type of heart failure in the elderly and its prevalence increases with age and is higher in females at any given age.HFpEF is frequently accompanied of comorbid conditions such as diabetes mellitus,obesity,atrial fibrillation and renal dysfunction.The diagnosis relies in the integration of clinical information,laboratory data and interpretation of cardiac imaging and hemodynamic findings at rest and during exercise.Conditions that have a specific treatment such as coronary artery disease,valvular disease,cardiac amyloidosis and constrictive pericarditis should be considered and evaluated as appropriate.Aggressive management of comorbidities,optimization of blood pressure control and volume status using diuretics as needed are among the current treatment recommendations.There are no specific therapies that have shown to decrease mortality in HFpEF.In symptomatic patients with history of hospital admission for decompensated heart failure,the implantation of a wireless pulmonary artery pressure monitor should be considered.Finally,given the high mortality of this condition,goals of care discussion should be initiated early and involvement of palliative care medicine should be considered. | Ernesto Ruiz Duque Alexandros Briasoulis Paulino A Alvarez | 2019 | Journal of Geriatric Cardiology2019，16，5： | 13 |
| 2 | The oxidative stress menace to coronary vasculature: any place for ant oxidants? 显示文摘 | Briasoulis A Tousoulis D Antoniades C | 2009 | Curr Pharm Des2009，15，26： | 1 |
| 3 | Conflicting effects of nitric oxide and oxidative stress in chronic heart failure: potential therapeutic strategies显示文摘 | Tousoulis D Papageorgiou N Briasoulis A | 2012 | Heart Fail Rev2012，17，1： | 1 |
| 4 | Endo- thelial dysfunction and atherosclerosis: focus on nov- el therapeutic approaches显示文摘 | Briasoulis A Tousoulis D Androulakis ES | 2012 | Recent Pat Cardiovasc Drug Discov2012，7，1： | 1 |
| 5 | Immunohistochemical expression of extracellular matrix components tenascin,fibronectin,collagen type Ⅳ and laminin in breast cancer:their prognostic value and role in tumour invasion and progression显示文摘 | IOACHIM E CHARCHANTI A BRIASOULIS E | 2002 | Eur J Cancer2002，38，18： | 1 |
| 6 | Alcohol consumption and the risk of hypertension in men and women: a systematic review and meta-analysis显示文摘 | Briasoulis A Agarwal V Messerli FH | 2012 | J Clin Hypertens2012，14，11： | 1 |
| 7 | The failure of immunomodulation therapy in heart failure: does the statins ' paradigm' prove the rule? 显示文摘 | Tousoulis D Papageorgiou N Briasoulis A | 2010 | Curr Vasc Pharmaeol2010，8，1： | 1 |
| 8 | The future of interventional management of hypertension :treats and opportunities显示文摘 | I Briasoulis A Bakris G | 2014 | Current vascular pharmacol ogy2014，12，1： | 1 |
| 9 | Conflicting effects of nitric oxide and oxidative stress in chronic heart failure:potential therapeutic strategies显示文摘 | TOUSOULIS D PAPAGEORGIOU N BRIASOULIS A | 2012 | Heart Fail Rev2012，17，1： | 1 |
| 10 | Effects of renin-angiotensin system blockade on mortality and hospitalization in heart failure with preserved ejection fraction显示文摘 | Agarwal V Briasoulis A Messerli FH | | 0，，04： | 1 |
| 11 | 肾素血管紧张素醛固酮系统抑制剂与新型冠状病毒肺炎易感性和死亡率关系的荟萃分析显示文摘有人认为使用血管紧张素转换酶抑制药(angiotensin-converting enzyme inhibitor,ACEI)和血管紧张素受体阻滞药(angiotensin receptor blocker,ARB)可能会改变人类对新型冠状病毒肺炎(corona virus disease 2019,COVID-19)的易感性。因此,研究者进行两次荟萃分析,以评估ACEI和ARB对COVID-19的死亡率和易感性的影响。研究者检索Pubmed和EMBASE数据库,截至2020年6月,纳入研究接受或未接受ACEI和/或ARB治疗患者COVID-19检测阳性率和院内死亡率的临床试验。第一项分析评估COVID-19的检测阳性率。 | 周卫(译) 练桂丽(审校) Yokoyama Y Aikawa T Takagi H Briasoulis A Kuno T | 2021 | 中华高血压杂志2021，29，8： | 1 |
| 12 | Effects of reninangiotensin system blockade on mortality and hospitalization in heart failure with preserved ejection fraction显示文摘 | Agarwal V Briasoulis A Messerli F H | 2013 | Heart Fail Rev2013，18，4： | 1 |
| 13 | A novel pericardial ef{usion scoring index to guide decision for drainage显示文摘 | Halpern DG Argulian E Briasoulis A | 2012 | Crit Pathw Cardiol2012，11，2： | 1 |
| 14 | The role of endothelial progenitor cells in vascular repair after arterial injury and atherosclerotic plaque development显示文摘 | Briasoulis A Tousoulis D Antoniades C | 2011 | Cardio- vase Ther2011，29，2： | 1 |
| 15 | Immunohistochemical expression of extracellular matrix components tenascin,fibronectin,collagen type Ⅳ and laminin in breast cancer:their prognostic value and role in tumour invasion and progression显示文摘 | Ioachim E Charchanti A Briasoulis E | 2002 | Eur J Cancer2002，38，18： | 1 |
| 16 | Targeting myocardial metabolism for the treatment of stable angina显示文摘 | Tousoulis D Bakogiannis C Briasoulis A | 2013 | Curr Pharm Des2013，19，9： | 1 |
| 17 | Alcohol consumption and the risk of hypertension in men and women: a systematic review and meta- analysis显示文摘 | Briasoulis A | 2012 | J Clin Hy- pertens (Greenwich)2012，14，11： | 1 |
| 18 | Potential pathogenic inflammatory mechanisms of endothelial dys- function induced by type 2 diabetes mellitus显示文摘 | Kampoli AM Tousoulis D Briasoulis A | 2011 | Curr Pharm Des2011，17，37： | 1 |
| 19 | Mechanisms of resistance to epidermal growth factor receptor tyrosine kinase inhibitors in patients with advanced non-small-cell lung cancer: clinical and molecular considerations显示文摘 | Pallis A Briasoulis E Linardou H | 2011 | Current Medicinal Chemistry2011，18，11： | 1 |
| 20 | Potential pathogenic inflammatory mechanisms of endothelial dysfunction induced by type 2 diabetes mellitus 显示文摘 | Kampoli AM Tousoulis D Briasoulis A | 2011 | Curr Pharm Des2011，17，37： | 1 |
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