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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | Antisense oligonucleotide-mediated inhibition of hTERT, but not hTERC, induces rapid cell growth decline and apoptosis in the absence of telomere shortening in human prostate cancer cells显示文摘 | Folini M Brambilla C Villa R | 2005 | Eur J Cancer2005，416，： | 1 |
| 3 | Envi- ronmental degradation of isotactic polypropylene plates as studied by positron annihilation lifetime spectroscopy 显示文摘 | BRAMBILLA L CONSOLATI G GALLO R | 2003 | Polymer2003，44，4： | 1 |
| 4 | Inhibition of astroglial nuclear factor kappa B reduces inflammation and improves functional recovery after spinal cord injury 显示文摘 | Brambilla R Bracchi-Ricard V Hu WH | 2005 | J Exp Med2005，202，1： | 1 |
| 5 | Aspirin-angiotension-coverting enzyme inhibitor coadministration and mortality in patients with heart failure 显示文摘 | Guazzi M Brambilla R Reina G | 2003 | Arth Intern Meal2003，163，13： | 1 |
| 6 | Morphologicalanalysis of female gametophyte development in the bellstk shpl shp2 mutant显示文摘 | Battaglia R Brambilla V Colombo L | 2008 | Plant Biosyst2008，142，： | 1 |
| 7 | Morphologicalanalysis of female gametophyte development in the bellstk shpl shp2 mutant显示文摘 | Battaglia R Brambilla V Colombo L | 2008 | Plant Biosyst2008，142，： | 1 |
| 8 | Genetic andmolecular interactions between BELLI and MADS Boxfactors support ovule development in Arabidopsis 显示文摘 | Brambilla V Battaglia R Colombo M | 2007 | Plant Cell2007，19，： | 1 |
| 9 | Vinorelbine:an active,non cross-resislaru drug in advanced breast cancer:Results from a phaseⅡstudy显示文摘 | Terenziani M Demicheli R Brambilla C | 1996 | Breast Cancer Res Treat1996，39，3： | 1 |
| 10 | Inactivation ofastroglial NF-kB promotes survival ofretinal neurons following ischemic injury显示文摘 | Dvoriantchikova G Barakat D Brambilla R | 2009 | Eur J Neurosci2009，30，2： | 1 |
| 11 | Alteration of complex Ⅳ and acetylcholine-related enzymes in experimental spinal cord injury显示文摘 | Brambilla G Sangiovanni G Pugliese R | 1996 | J Neurosurg Sci1996，40，34： | 1 |
| 12 | Cytokines and immunity in multiple sclerosis: the dual signal hypothesis显示文摘 | Furlan R Brambilla E | 2000 | J Neuroimmunol2000，109，： | 1 |
| 13 | Visceral pleural invasion: pathologic criteria and use of elastic stains: proposal for the 7th edition of the TNM classification for lung cancer 显示文摘 | Travis WD Brambilla E Rami-Porta R | 2008 | J Thorac Oncol2008，3，12： | 1 |
| 14 | Onset mechanism of paroxysmal atrial fibrillation detected by ambulatory Holter monitoring显示文摘 | Vincenti A Brambilla R Fumagalli MG | | 0，，： | 1 |
| 15 | Inhibition of as- troglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury显示文摘 | Brambilla R Bracchi-Ricard V Hu WH | 2005 | J Exp Med2005，202，1： | 1 |
| 16 | Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury 显示文摘 | Brambilla R Bracchi-Ricard V Hu WH | 2005 | J Exp Med2005，202，1： | 1 |
| 17 | Cytokines and immunity in multiple sclerosis the signa hypothesis显示文摘 | Martino G Furlan R Brambilla E | 2000 | J Neuroimmunol2000，109，： | 1 |
| 18 | Oetadecylsilane hybrid silicas prepared by the sol -gel method :Morphological and textur- al aspects 显示文摘 | BRAMBILLA R PIRES G P | 2007 | Journal of Colloid and Interface Science2007，312，2： | 1 |
| 19 | A simple role for BDNF in learning and memory显示文摘 | Cunha C Brambilla R Thomas KL | 2010 | Front Mol Neurosci2010，3，： | 1 |
| 20 | Vinorelbine:an active non cross-resistant drug in advanced breast cancer:results from a phase Ⅱ study显示文摘 | Demichel R Brambilla C | 1996 | Breast Cancer Res Tveat1996，39，： | 1 |
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