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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Assessing the relationship between the rumen microbiota and feed efficiency in Nellore steers显示文摘Background:Ruminants rely upon a complex community of microbes in their rumen to convert host-indigestible feed into nutrients.However,little is known about the association between the rumen microbiota and feed efficiency traits in Nellore(Bos indicus)cattle,a breed of major economic importance to the global beef market.Here,we compare the composition of the bacterial,archaeal and fungal communities in the rumen of Nellore steers with high and low feed efficiency(FE)phenotypes,as measured by residual feed intake(RFI).Results:The Firmicutes to Bacteroidetes ratio was significantly higher(P<0.05)in positive-RFI steers(p-RFI,low feed efficiency)than in negative-RFI(n-RFI,high feed efficiency)steers.The differences in bacterial composition from steers with high and low FE were mainly associated with members of the families Lachnospiraceae,Ruminococcaceae and Christensenellaceae,as well as the genus Prevotella.Archaeal community richness was lower(P<0.05)in p-RFI than in n-RFI steers and the genus Methanobrevibacter was either increased or exclusive of p-RFI steers.The fungal genus Buwchfawromyces was more abundant in the rumen solid fraction of n-RFI steers(P<0.05)and a highly abundant OTU belonging to the genus Piromyces was also increased in the rumen microbiota of highefficiency steers.However,analysis of rumen fermentation variables and functional predictions indicated similar metabolic outputs for the microbiota of distinct FE groups.Conclusions:Our results demonstrate that differences in the ruminal microbiota of high and low FE Nellore steers comprise specific taxa from the bacterial,archaeal and fungal communities.Biomarker OTUs belonging to the genus Piromyces were identified in animals showing high feed efficiency,whereas among archaea,Methanobrevibacter was associated with steers classified as p-RFI.The identification of specific RFI-associated microorganisms in Nellore steers could guide further studies targeting the isolation and functional characterization of rumen microbes potentially important for the energy-harvesting efficiency of ruminants. | Déborah Romaskevis Gomes Lopes Márcio de Souza Duarte Alex J.La Reau Ibrahim Zuniga Chaves Tiago Antônio de Oliveira Mendes Edenio Detmann Cláudia Braga Pereira Bento Maria Eugênia Zerlotti Mercadante Sarah Figueiredo Martins Bonilha Garret Suen Hilário Cuquetto Mantovani | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 3 |
| 3 | The role ofregulatory T cells and TH17 cells in multiple myeloma显示文摘 | Braga WM Atanackovic D Colleoni GW | 2012 | Clin Dev Immunol2012，，： | 1 |
| 4 | Site-specific effects of strength training on bone structure and geometry of ultra distal radius in postmenopausal women显示文摘 | Asami S Gatti D Braga V | 1999 | J Bone Miner Res1999，14，1： | 1 |
| 5 | Accuracy of 3D recon- structions based on cone beam computed tomography显示文摘 | Maret D Molinier F Braga J | 2010 | J Dent Res2010，89，12： | 1 |
| 6 | Enzyme activities associated with oxidative stress in Metarhizium anisopliae during germination, mycelial growth, and conidiation and in response to near-UV irradiation 显示文摘 | MILLER C D RANGEL D BRAGA G U | 2004 | Canadian Journal of Microbiology2004，50，1： | 1 |
| 7 | Validation of the NHANES ADL scale in a sample of patients with report of cervical pain:factor analysis,item response theory analysis, and line i- tem validity 显示文摘 | Cook CE Richardson JK Pietrobon R Braga L Silva HM Turner D | 2006 | Disabil Rehabil2006，22，： | 1 |
| 8 | Bifurcation analysis of the Watt governor system 显示文摘 | Sotomayor J Mello L F Braga D C | 2007 | Comp Appl Math2007，26，： | 1 |
| 9 | Controllable hopf bifurcations of codimension 1 and 2 in nonlinear control systems 显示文摘 | de Carvalho Braga D Mello L F | 2011 | Nonlinear Analysis2011，74，9： | 1 |
| 10 | En- zyme activities associated with oxidative stress in Metarhizium anisopliae during germination, mycelial growth, and conidiation and in response to near-UV irradiation 显示文摘 | MILLER C D RANGEL D BRAGA G U | 2004 | Canadian Journal of Microbiology2004，50，1： | 1 |
| 11 | New malaria vaccine candidates based on the Plasmodium vivax merozoite surface protein-1 and the TLR-5 agonist Salmonella Typhimurium FliC flagellin显示文摘 | Bargieri D Y Rosa D S Braga C J | 2008 | Vaccine2008，26，： | 1 |
| 12 | Cognitive-behavioral group therapy in obsessive-compulsive disorder:a randomized clinical trial显示文摘 | Volpato Cordioli A Heldt E Braga Bochi D | 2003 | Psychother Psychosom2003，72，4： | 1 |
| 13 | Bifurcation Analysis of the Watt Governor System 显示文摘 | SOTOMAYOR J MELLO L F BRAGA D C | 2007 | Computational Applied Mathematics2007，26，： | 1 |
| 14 | Catalytic applications of chiral organoselenium compounds in asymmetric synthesis显示文摘 | Braga A L Ludtke D S Vargas F | 2006 | Synlett2006，，： | 1 |
| 15 | A MURA-based coded mask telescope显示文摘 | Villela T Braga J Amico F D | 1995 | Advances in Space Research1995，15，5： | 1 |
| 16 | Crystal Engineering and Oranometallic Architecture显示文摘 | Braga D Grepion F Desiraju G R | 1998 | Chem Rev1998，98，： | 1 |
| 17 | Stereoselective formation of N-Acyliminium ion via chiral N, O-acetal TMS ether and its application to the synthesis of β-amino acids显示文摘 | Braga A L Paixao M W Ludtke D S | 2003 | Org Lett2003，5，： | 1 |
| 18 | S100B and NSE serum levels in obstructive sleep apnea syndrome显示文摘 | Braga CW Martinez D Wofchuk S | | 0，，： | 1 |
| 19 | Ventral penile lengthening versus dorsal plication for severe ventral curvature in children with proximal hypospadias 显示文摘 | Braga LH Lorenzo A J Bagli D J | 2008 | J Urol2008，180，4： | 1 |
| 20 | Quantitative determination of the band gap of WS2 with ambipolar ionic liquid-gated transistors 显示文摘 | BRAGA D GUTII~RREZ L I BERGER H | 2012 | Nano Let- ters2012，12，10： | 1 |
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