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| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | On the measurement of thickness of ice layers on power transmission lines显示文摘 | Xu Y Bosisio R | 2007 | SensImaging2007，8，2： | 1 |
| 3 | Goubau Ice Sensor Transitions for Electric Power Lines显示文摘 | Xu Y Bosisio R | 2009 | Senslmaging2009，10，12： | 1 |
| 4 | An alterative explicit six-port matrix calibration formalism using five standards显示文摘 | Ghannouchi F M Bosisio R G | 1988 | IEEE Transactions on Microwave Theory and Techniques1988，36，3： | 1 |
| 5 | W-band muhiport sub- strate-integrated waveguide circuits 显示文摘 | Moldovan E Bosisio R G Wu K | 2006 | IEEE Trans on Microwave Theory and Techniques2006，54，2： | 1 |
| 6 | The sixport reflectometer and its complete calibration by four standard terminations显示文摘 | Ghannouchi F M Bosisio R G | 1988 | Microwaves Antennas and Propagation IEE Proceedings1988，135，4： | 1 |
| 7 | Computer and measurement simulation of a new digital receiver operating directly at millimeter-wave frequencies显示文摘 | J Li R G Bosisio K Wu | 1995 | IEEE Transactions on Microwave Theory and Techniques1995，43，12： | 1 |
| 8 | Asphalt road maintenance with a mobile microwave power unit显示文摘 | Bosisio R G Spooner J Granger J | 1974 | Journal of Microwave Power1974，9，4： | 1 |
| 9 | Differential expression and regulation of Toll-like receptors(TLR) in human leukocytes: seleetive expression of TLR3 in dendritic cells显示文摘 | Muzio M Bosisio D Polentarutti N D'amico G Stoppacciaro A Mancinelli R | 2000 | J Immunol2000，164，11： | 1 |
| 10 | Accurate closed form expressions for characteristic impedance of coupled line with sliced coaxial cable显示文摘 | An H Wang T Bosisio R G | 2010 | Electronics Letters2010，31，23： | 1 |
| 11 | Differential expression and regulation of Toll-like receptors(TLR) in human leukocytes: selective expression of TLR3 in dendritic cells 显示文摘 | Muzio M Bosisio D Polentarutti N D' antico G Stoppacciaro A Mancinelli R | 2000 | J Immunol2000，164，11： | 1 |
| 12 | Beam selection strategies for orthogonal random beamforming in sparse networks显示文摘 | VICARIO J L BOSISIO R ANTON-HARO C | 2008 | IEEE Transactions on Wireless Communications2008，7，9： | 1 |
| 13 | Differential expressionand regulation of toll-like receptors (TLR)in humanleukocytes:selective expression of TLR3 in dendriticcells显示文摘 | Muzio M Bosisio D Polentarutti N D amico G Stop-pacciaro A Mancinelli R | 2000 | J Immunol2000，164，： | 1 |
| 14 | IEEE Analysis and implementation of six port software-defined radio receiver platform显示文摘 | XU X Y WU K BOSISIO R G | 2006 | IEEE Transactions on Microwave Theory and Techniques2006，54，7： | 1 |
| 15 | The six-port reflectometer and its complete calibration by four standard terminations显示文摘 | Ghannouchi F M Bosisio R G | 1988 | IEE Proceeding S-H: Microwaves Antennas and Propagation1988，135，4： | 1 |
| 16 | Analysis and implementation of six-portsoftware-defined radio receiver platform 显示文摘 | XU X Y BOSISIO R G WU K | 2006 | IEEE Trans MicrowaveTheory Tech2006，54，7： | 1 |
| 17 | Wave-Radio Interferometer transceiver for UWB显示文摘 | ALJERJAWI M NERGUIZIAN C BOSISIO R C | 2009 | IEEE on Microwave Symposium Digest2009，9，11： | 1 |
| 18 | Dynamic high temperature microwave complex permittivity measurements on samples heated via microwave absorption显示文摘 | Couderc D Giroux M Bosisio R G | 1973 | J Microwave Power1973，8，1： | 1 |
| 19 | Beam selection strategies for orthogonal random beamforming in sparse networks显示文摘 | VICARIO J BOSISIO L R ANTON-HARO C | 2008 | IEEE Transations on Wireless Communications2008，7，9： | 1 |
| 20 | Measurement of Microwave Permittivity Using a Six-Port Reflectometer with an Open-Ended Coaxial Line显示文摘 | Ghannouchi F M Bosisio R G | 1989 | IEEE Trans on Instrumentation And Measursment1989，38，4： | 1 |
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