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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Successful pregnancy following aplastic anaemia显示文摘 | Leong KW Teh A Bosco JJ | 1995 | Postgrad Med J1995，71，840： | 1 |
| 3 | Preventing Burnout in Mental Health Workers at Interpersonal Level : An Italian Pilot stuay 显示文摘 | Scamem P Bosco A Soleti E | 2009 | Community Ment Health J2009，45，： | 1 |
| 4 | Expression of bcl-2, c-erbB- 2, p53, and p21 (waf1 -cip1) protein in thyroid carcinomas 显示文摘 | Soda G Antonaci A Bosco D | 1999 | J Exp Clin Cancer Res1999，18，3： | 1 |
| 5 | Lower apoptosis rate in human cumulus cells after administration of recombinant luteinizing hormone to women undergoing ovarian stimulation for in vitro fertilization procedures显示文摘 | Ruvolo G Bosco L Pane A | 2007 | Fertil Steril2007，87，3： | 1 |
| 6 | Effect of organic produc-tion system on broiler carcass and meat quality显示文摘 | Castellini C M ugnai C Dal Bosco A | 2002 | Meat Sci2002，60，3： | 1 |
| 7 | Sequential kidney/islet transplantation:efficacy and safety assessment of a steroid-free immunosuppression protocol显示文摘 | Toso C Baertschiger R Morel P Bosco D Armanet M Wojtusciszyn A | | 0，，： | 1 |
| 8 | Ovulating induction methods in rabbit does:the pituitary and ovarian responses显示文摘 | Rebollar P.G Dal Bosco A Millàn P | | 0，，： | 1 |
| 9 | An overview of intervention options for promoting adaptive behavior of persons with acquired brain injury and minimally conscious state 显示文摘 | Lancioni GE Bosco A Belardinelli MO | 2010 | Research in Developmental Disabilities2010，31，： | 1 |
| 10 | Imaging of acute cholecystitis and cholecystitis-associated complications in the emergency setting显示文摘 | Chawla A Bosco JI Lim TC | 2015 | Singapore Med J2015，56，8： | 1 |
| 11 | A posteriori error estimates for fully discrete nonlinear parabolic problems显示文摘 | Javier F Bosco G A Julia N | 2007 | Comput Methods Appl Mech Engrg2007，196，： | 1 |
| 12 | Effect of thalidomide and rosiglitazone on the prevention of diabetic retinopathy in streptozotocin-induced diabetic rats显示文摘 | Bosco A A Lerario A C Santos R F | 2003 | Diabetologia2003，46，12： | 1 |
| 13 | Possible implications of insulin re- sistance and glucose metabolism in Alzheimer' s disease pathogenesis 显示文摘 | Bosco D Fava A Plastino M | 2011 | J Cell M012011，15，9： | 1 |
| 14 | Magnesium perchlorate as efficient Lewis acid for the Knoevenagel conden- sation between 13-diketones and aldehydes 显示文摘 | BARTOLI G BOSCO M CARLONE A | 2008 | Tetrahedron Letters2008，49，16： | 1 |
| 15 | A large aperture electro-optic deflector显示文摘 | BOSCO A BOOGERT S T BOORMAN G E | 2009 | Applied Physics Letters2009，94，21： | 1 |
| 16 | Modeling of the impact of nonlinear propagation effects in uncompensated optical coherent transmission links 显示文摘 | Carena A Ourri V Bosco G | 2012 | Journal of Lightwave Technology2012，30，10： | 1 |
| 17 | Audiogenic seizures susceptibility in transgemic mice with fragile X syndrome 显示文摘 | Musumeci S A Bosco P Colabrese G | 2000 | Epilepsia2000，41，： | 1 |
| 18 | Effect of dietary α- linolenic acid and vitamin E on the fatty acid composition, storage stability and sensory traits of rabbit meat显示文摘 | Dal Bosco A Castellini C Bianchl L | 2004 | Meat Sci2004，66，： | 1 |
| 19 | Pharmacokinet- ics of a novel submicron budesonide dispersion for nebulized de- livery in asthma 显示文摘 | SHREWSBURY S B BOSCO A P USTER P S | 2009 | Int J Pharm2009，365，12： | 1 |
| 20 | Catalysis and binding of cyclophilin A with different H1V-1 capsid constructs 显示文摘 | Bosco D A Kem D | 2004 | Biochemistry2004，43，20： | 1 |
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