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| 1 | Mucosal healing progression after acute colitis in mice显示文摘BACKGROUND Mucosal healing has become a therapeutic goal to achieve stable remission in patients with inflammatory bowel diseases. To achieve this objective, overlapping actions of complex cellular processes, such as migration, proliferation, and differentiation, are required. These events are longitudinally and tightly controlled by numerous factors including a wide range of distinct regulatory proteins. However, the sequence of events associated with colon mucosal repair after colitis and the evolution of the luminal content characteristics during this process have been little studied.AIM To document the evolution of colon mucosal characteristics during mucosal healing using a mouse model with chemically-induced colitis.METHODS C57 BL/6 male mice were given 3.5% dextran sodium sulfate(DSS) in drinking water for 5 d. They were euthanized 2(day 7), 5(day 10), 8(day 13), and 23(day28) d after DSS removal. The colonic luminal environment and epithelial repair processes during the inflammatory flare and colitis resolution were analyzed with reference to a non-DSS treated control group, euthanized at day 0. Epithelial repair events were assessed histo-morphologically in combination with functional permeability tests, expression of key inflammatory and repairing factors, and evaluation of colon mucosa-adherent microbiota composition by 16 S rRNA sequencing.RESULTS The maximal intensity of colitis was concomitant with maximal alterations of intestinal barrier function and histological damage associated with goblet cell depletion in colon mucosa. It was recorded 2 d after termination of the DSStreatment, followed by a progressive return to values similar to those of control mice. Although signs of colitis were severe(inflammatory cell infiltrate, crypt disarray, increased permeability) and associated with colonic luminal alterations(hyperosmolarity, dysbiosis, decrease in short-chain fatty acid content), epithelial healing processes were launched early during the inflammatory flare with increased gene expression of certain key epithelial repair modulators, including transforming growth factor-β, interleukin(Il)-15, Il-22, Il-33, and serum amyloid A. Whereas signs of inflammation progressively diminished, luminal colonic environment alterations and microscopic abnormalities of colon mucosa persisted long after colitis induction.CONCLUSION This study shows that colon repair can be initiated in the context of inflamed mucosa associated with alterations of the luminal environment and highlights the longitudinal involvement of key modulators. | Sandra Vidal-Lletjós Mireille Andriamihaja Anne Blais Marta Grauso Patricia Lepage Anne-Marie Davila Claire Gaudichon Marion Leclerc Francois Blachier Annaig Lan | 2019 | World Journal of Gastroenterology2019，25，27： | 5 |
| 2 | Effects of TNF-alpha and IFN-gamma on nitric oxide-induced neurotoxieity in the mouse brain显示文摘 | Blais V Rivest S | 2004 | J Immunol2004，172，11： | 1 |
| 3 | Relative effectiveness of budesonide/formoterol and fluticasone propionate/salmeterol in a 1-year,population-based,matched cohort study of patients with chronic obstructive pulmonary disease(COPD):effect on COPD-related exacerbations,emergency department visits and hospitalizations,medication utilization,and treatment adherence显示文摘 | Blais L Forget A Ramachandran S | 2010 | Clin Ther2010，32，7： | 1 |
| 4 | Extraction of Cr(Ⅲ)and other metals from tannery sludge by mineral acids显示文摘 | Shen S B Tyagi R D Blais J F | 2001 | Environ Technol2001，22，9： | 1 |
| 5 | Ppargamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection显示文摘 | Hanley T M Blay Puryear W Gummuluru S | | 0，，06： | 1 |
| 6 | A study of the stability of tri(glucosyloxyphenyl) chlorin,a sensitizer for photodynamic therapy,in human colon tumoural cells : a liquid chromatography and MAL-DI-TOF mass spectrometry analysis 显示文摘 | Laville I Pigaglio S Blais J C | 2004 | Bioorg Med Chem2004，12，13： | 1 |
| 7 | Effects of TNF-alpha and IFN-gamma on nitric oxide-induced neurotoxieity in the mouse brain 显示文摘 | Blais V Rivest S | 2004 | J Immunol2004，172，11： | 1 |
| 8 | Sequen-tial Abeta degradation by the matrix metalloproteases MMP-2and MMP-9 显示文摘 | Hernandez- Guillamon M Mawhirt S Blais S | 2015 | JBiol Chem2015，290，15： | 1 |
| 9 | Cognitive-behavioral group therapy is an effective treatment for the major depression in the hemodialysis patients显示文摘 | DUARTE P S MIYAZAKI M C BLAY S L | 2009 | Kindey Int2009，76，4： | 1 |
| 10 | Bronchodilators and acute cardiac death显示文摘 | Suissa S Hemmelgam B Blais L | 1996 | Am J Respir Crit Care Med1996，154，： | 1 |
| 11 | Thixoforming of an automotive part in A390 hypereutectic Al-Si alloy显示文摘 | KAPRANOS P KIRKWOOD D H ATKINSON H V RHEINLANDER J T BENTZEN J J TOFT P T DEBEL C P LASLAZ G MAENNER L BLAIS S RODRIGUEZ-IBABE J M LASA L GIORDANO P CHIARMETTA G GIESE A | 2003 | J Mater Process Tech2003，135，23： | 1 |
| 12 | Monopole Antennas Catheter Ablation for Microwave 显示文摘 | Labontk S Blais A Legault SR | 1996 | IEEE Transactions on Microwave Theory and Techniques1996，44，10： | 1 |
| 13 | Impact of valve prosthesis-patient mismatch on short-term mortality after aortic valve replacement显示文摘 | Blais C Dumesnil J G Baillot R Simard S Doyle D Pibarot P | 2003 | Circulation2003，108，： | 1 |
| 14 | Biodegradation of mono-al- kyl phthalate esters in natural sediments 显示文摘 | OTI'ON S V SURA S BLAI J | 2008 | Chemosphere2008，71，： | 1 |
| 15 | Consensus meeting for the management of gastrointestinal stromal tumors显示文摘 | Blay J Y Bonvalot S Casali P | 2005 | Ann Oncol2005，16，4： | 1 |
| 16 | Extracorporeal membrane oxygenation for pandemic(H1N1)2009显示文摘 | Firstenberg M S Blais D Louis L B | 2009 | Emerg Infect Dis2009，15，12： | 1 |
| 17 | Photodynamic effi- ciency of diethylene glycol-linked glycoconjugated porphy- fins in human retinoblastoma cells 显示文摘 | Laville I Pigaglio S Blais J C | 2006 | J Med Chem2006，49，8： | 1 |
| 18 | Optical uhrawideband monocy- cle pulse generation based on cross-gain modulation in a semicon- ductor optical amplifier 显示文摘 | WANG Q ZENG F BLAIS S | 2006 | Opt Lett2006，31，21： | 1 |
| 19 | HLA-C as a mediator of natural killer and T-cell Activeation:spectator or key player显示文摘 | Blais ME Dong T Rowland-Jones S | 2011 | Lmmunology2011，，1： | 1 |
| 20 | Molting cycle-dependent expression of CYP4C15, a cytochrome P450 enzyme putatively involved in ecdysteroidgenesis in the crayfish Orconectes limosus显示文摘 | Aragon S Claudinot S Blais C | 2002 | Insect Biochemistry and Molecular Biology2002，32，： | 1 |
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