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| 1 | Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma显示文摘AIM: To determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma(HCC).METHODS: Sixty-eight patients with HCC(mean age of 69.1 ± 10.1), 31 cirrhosis patients(mean age of59.3 ± 6.3) and 33 healthy volunteers(mean age of51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein(AFP) values with HCC clinicopathological features, such as tumor size,number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion(diameters; ≤ 3 cm, 3-5 cmand ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer(BCLC)criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alphafetoprotein levels were kept at-80 ℃ until use.Prolidase levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic assay.RESULTS: In patients with HCC, prolidase and AFP values were evaluated according to tumor size, number,presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls(P <0.001). Prolidase levels were significantly associated with tumor size and number(P < 0.001, P = 0.002,respectively). Prolidase levels also differed in patients in terms of BCLC staging classification(P < 0.001).Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis(P < 0.001). In HCC patients grouped according to tumor size, number and BCLC staging classification, AFP values differed separately(P = 0.032,P = 0.038, P = 0.015, respectively). In patients with HCC, there was a significant correlation(r = 0.616; P< 0.001) between prolidase and AFP values in terms of tumor size, number and BCLC staging classification,whereas the presence of macrovascular invasion did not show a positive association with serum prolidase and AFP levels.CONCLUSION: Considering the levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. | Sevil Uygun Ilikhan Muammer Bilici Hatice Sahin Ayse Semra Demir Akca Murat Can Ibrahim Ilker Oz Berrak Guven M Cagatay Buyukuysal Yucel Ustundag | 2015 | World Journal of Gastroenterology2015，21，22： | 8 |
| 2 | Clinical value of FDG PET/CT in the diagnosis of suspected recurrent ovarian cancer:is there an impact of FDG PET/CT on patient management显示文摘 | Bilici A Ustaalioglu BB Seker M | 2010 | Eur J Nucl Med Mol Imaging2010，37，： | 1 |
| 3 | Determining predominating histologic component in malignant mixed m llerian tumors: is it worth it?显示文摘 | Ozguroglu M Bilici A Ilvan S | 2008 | Int J Gynecol Cancer2008，18，4： | 1 |
| 4 | Effect of mirtazapine on MNNG-induced gastric adenocarcinoma in rats显示文摘 | Bilici M Cayir K Tekin S B | 2012 | Asian Pac J Cancer Prev2012，13，10： | 1 |
| 5 | Circulating levels of IGF-I and IGFBP-3 in gastric cancer 显示文摘 | Ahinkaynak K Bilici M Bakan N | 2012 | Turkish Journal of Medical Sci- ences2012，42，9： | 1 |
| 6 | Prognostic significance of perineural invasion in patients with gastric cancer who underwent cur- ative resection显示文摘 | Bilici A Seker M Ustaalioglu BBO | 2010 | Ann Surg Onco12010，17，8： | 1 |
| 7 | Comparison of dartos flap and dartos flap plus spongioplasty to prevent the formation of fis- tulae in the Snodgrass technique显示文摘 | Bilici S Sekmenli T Gunes M | 2011 | Int Urol Nephrol2011，43，4： | 1 |
| 8 | Effect of mirtazapine on MNNG-in- duced gastric adenocarcinoma in rats 显示文摘 | Bilici M Cayir K Tekin SB | 2012 | Asian Pac J Cancer Prev2012，13，10： | 1 |
| 9 | Prognostic significance of perineural invasion in patients with gastric cancer who underwent curative resection显示文摘 | Bilici A Seker M Ustaalioglu BB | 2010 | Ann Surg Oncol2010，17，8： | 1 |
| 10 | Steroid responsiveness of children with idiopathic nephrotic syndrome in south- eastern region of Turkey显示文摘 | DAVUTOGLU M ECE A BILICI M | 2007 | Ren Fail2007，29，7： | 1 |
| 11 | Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments 显示文摘 | Bilici M | 2001 | J Affective Disorders2001，64，1： | 1 |
| 12 | Prognostic significance of perineural invasion in patients with gastric cancer who undergoing curative resection显示文摘 | A Bilici M Seker B Basak | 2010 | Surg Oncol2010，17，8： | 1 |
| 13 | 3-T MRI of the biliary tract variations显示文摘 | Hakan ?nder Muhammed S?dd?k ?zdemir Güven Tekba? Faysal Ekici Hatice Gümü? Aslan Bilici | 2013 | Surgical and Radiologic Anatomy2013，，2： | 1 |
| 14 | Serum adiponectin levels in pa- tients with esophageal cancer 显示文摘 | Yildirim A Bilici M Cayir K | 2009 | Jpn J Clin Oncol2009，39，2： | 1 |
| 15 | Effect of tool geometry on friction stir spot welding of polypropylene sheets 显示文摘 | Bilici M K | 2012 | Express Polymer Ietters2012，6，10： | 1 |
| 16 | Effects of paliperidone extended release on functioning level and symptoms of patients with recent onset schizophrenia: An open-label, single-arm, flexible-dose, 12-months follow-up study 显示文摘 | UCOK A SAKA M C BILICI M | 2015 | Nord J Psychiatry2015，69，6： | 1 |
| 17 | The role of 18F-FDG PET/CT in the assessment of suspected recurrent gastric cancer after initial surgical resection:can the results of FDG PET/CT influence patients' treatment decision making显示文摘 | Bilici A Ustaalioglu BB Seker M | | 0，，： | 1 |
| 18 | The association of pre treatment peripheral blood markers with survival in patients with pancreatic cancer显示文摘 | Aliustaoglu M Bilici A Seker M | 2010 | Hepatogastroenterolo- gy2010，57，99100： | 1 |
| 19 | Mean platelet volume in diagnosis of acute appendicitis in children显示文摘 | Bilici S Sekmenli T G(o)ksu M | | 0，，03： | 1 |
| 20 | Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue显示文摘 | Dursun H Bilici M Albayrak F | | 0，，： | 1 |
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