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| 1 | Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet显示文摘AIM To determine the effect of tempol in normal rats fed high salt on arterial pressure and the balance between antagonist components of the renal renin-angiotensin system.METHODS Sprague-Dawley rats were fed with 8% Na Cl highsalt(HS) or 0.4% Na Cl(normal-salt,NS) diet for 3 wk,with or without tempol(T)(1 mmol/L,administered in drinking water). Mean arterial pressure(MAP),glomerularfiltration rate(GFR),and urinary sodium excretion(UVNa) were measured. We evaluated angiotensin Ⅱ(Ang Ⅱ),angiotensin 1-7(Ang 1-7),angiotensin converting enzyme 2(ACE2),mas receptor(Mas R),angiotensin type 1 receptor(AT1R) and angiotensin type 2 receptor(AT2R) in renal tissues by immunohistochemistry.RESULTS The intake of high sodium produced a slight but significant increase in MAP and differentially regulated components of the renal renin-angiotensin system(RAS). This included an increase in Ang Ⅱ and AT1 R,and decrease in ACE-2 staining intensity using immunohistochemistry. Antioxidant supplementation with tempol increased natriuresis and GFR,prevented changes in blood pressure and reversed the imbalance of renal RAS components. This includes a decrease in Ang Ⅱ and AT1 R,as increase in AT2,ACE2,Ang(1-7) and Mas R staining intensity using immunohistochemistry. In addition,the natriuretic effects of tempol were observed in NS-T group,which showed an increased staining intensity of AT2,ACE2,Ang(1-7) and Mas R.CONCLUSION These findings suggest that a high salt diet leads to changes in the homeostasis and balance between opposing components of the renal RAS in hypertension to favour an increase in Ang Ⅱ. Chronic antioxidant supplementation can modulate the balance between the natriuretic and antinatriuretic components of the renal RAS. | Gabriel Cao Silvana Lorena Della Penna Nicolas Martín Kouyoumdzian Marcelo Roberto Choi Susana Gorzalczany Belisario Enrique Fernández Jorge Eduardo Toblli María Inés Roson | 2017 | World Journal of Nephrology2017，6，1： | 4 |
| 2 | Renal dopaminergic system:Pathophysiological implications and clinical perspectives显示文摘Fluid homeostasis, blood pressure and redox balance in the kidney are regulated by an intricate interaction between local and systemic anti-natriuretic and natriuretic systems. Intrarenal dopamine plays a central role on this interactive network. By activating specific receptors, dopamine promotes sodium excretion and stimulates anti-oxidant and anti-inflammatory pathways. Different pathological scenarios where renal sodium excretion is dysregulated, as in nephrotic syndrome, hypertension and renal inflammation, can be associated with impaired action of renal dopamine including alteration in biosynthesis, dopamine receptor expression and signal transduction. Given its properties on the regulation of renal blood flow and sodium excretion, exogenous dopamine has been postulated as a potential therapeutic strategy to prevent renal failure in critically ill patients. The aim of this review is to update and discuss on the most recent findings about renal dopaminergic system and its role in several diseases involving the kidneys and the potential use of dopamine as a nephroprotective agent. | Marcelo Roberto Choi Nicolás Martín Kouyoumdzian Natalia Lucía Rukavina Mikusic María Cecilia Kravetz María Inés Rosón Martín Rodríguez Fermepin Belisario Enrique Fernández | 2015 | World Journal of Nephrology2015，4，2： | 2 |
| 3 | First report of Alternaria alternata causing leaf spot on English walnut显示文摘 | BELISARIO A FORTI E CORAZZA L | 1999 | Plant disease1999，83，7： | 1 |
| 4 | First report of Alternaria species groups involved in disease complexes of ha-zelnut and walnut fruit显示文摘 | I Belisario A Maccaroni M Coramusi A | | 0，，04： | 1 |
| 5 | Against fusarium wilt of melon there is only breeding显示文摘 | Belisario A Corazza L | 2003 | Cohure Protette2003，32，2： | 1 |
| 6 | First Report of Alternaria Species Groups Involved in Disease Complexes of Hazelnut and Walnut Fruit显示文摘 | BELISARIO A MACCARONI M CORAMUSI A | 2004 | Plant Disease2004，88，4： | 1 |
| 7 | Thioredoxin system modulation by plant and fungal secondary metabolites 显示文摘 | Dal Piaz F Braca A Belisario MA | 2010 | Curr Med Chem2010，17，5： | 1 |
| 8 | Fusarium necrosis on Persian (English) walnut fruit显示文摘 | Belisario A Forti E Santori A | 2001 | Acta Hortic2001，544，： | 1 |
| 9 | Occurrence and e- tiology of brown apical necrosis on Persan (English) walnut fruit显示文摘 | Belisario A Maccaroni M Corazza L | 2002 | Plant Disease2002，6，： | 1 |
| 10 | First report of A lternaria species groups in-volved in disease complexes of hazelnut and walnut fruit显示文摘 | BELISARIO A MACCARONI M CORAMUSI A C0RAZZA L PRYOR B FIGULI P | 2004 | Plant Dis-ease2004，88，4： | 1 |
| 11 | Evaluation of root damage to English walnut caused by five Phytopthora species显示文摘 | Vettraino A M Belisario A | 2003 | Plant Pathology2003，52，4： | 1 |
| 12 | Metalion catalyzed oxidation affects fibrinogen activity on platelet aggregation and adhesion显示文摘 | Belisario MA Di Domenico CD Pelagalli A | 1997 | Biochimie1997，79，7： | 1 |
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