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| 1 | Association between low molecular polypeptide 7 single nucleotide polymorphism and response to therapy in hepatitis C virus infection显示文摘AIM: To investigate the relationship between low molecular polypeptide-7 (LMP-7) gene polymorphism and response to interferon (IFN) therapy in chronic hepatitis C virus (HCV) patients. METHODS: LMP-7 polymorphism at codon 49 with nucleotide substitution from A to C was amplified in 104 chronic HCV patients of genotype 4. The amplicons were digested with restriction endonuclease Bsm I and the produced restriction fragment length polymorphism was analyzed. Patients received IFN + regional blood volume therapy for 48 wk and the frequency of thissingle nucleotide polymorphism (SNP) was statistically correlated with treatment response. The exclusion criteria for these patients were stated by the national health program for treating viral hepatitis. Main exclusion criteria included co-infection with hepatitis B virus or schistosomiasis, thyroid dysfunction, uncontrolled diabetes mellitus, history of long term drug or alcohol intake and autoimmune hepatitis. Multivariate analyses were done to correlate LMP-7 SNP plus several factors such as age, gender, weight, serum alpha-fetoprotein (AFP) and alanine aminotransferase levels, liver activity, fibrosis score and viral load with response to therapy. RESULTS: The data presented in this study clearly demonstrated statistically significant differences between sustained virological response (SVR) (defined as the absence of HCV RNA levels in the patient's sera at least 6 mo after discontinuation of treatment) and non-response (NR) (where HCV RNA levels in the patient's sera never become undetectable for 6 mo during or after treatment). Variables were described as odds ratio with 95%CI. The data were considered significant if P values were ≤ 0.05; highly significant if P < 0.01 and very highly significant if P < 0.001. Current data showed that 91.7% of patients carrying LMP-7 C/C allele were associated with SVR, while the other two genotypes C/A and A/A were associated with NR patients, 83.3% and 64.3% respectively, showing that genotype CC was strongly associated with response to interferon (95%CI: 12.0719-134.6572, P = 0.0001). The majority of parameters recorded in SVR and NR patients included higher values of mean age (P = 0.004), alanine aminotransferase (P = 0.001), AFP (P = 0.001), body weight (P = 0.025), viral load (P = 0.025), higher fibrosis and histological activity index indices among NR vs SVR patients. Also, the multivariate statistical analysis of the different factors of fibro-sis score, liver activity grade, genotypes and alleles of LMP-7 gene polymorphism in responders and NRs of HCV patients in this study showed that HCV patients with A allele had a very highly significant association with the NRs, high fibrosis and higher liver activity, while the C allele had a very highly significant association with the responders, low fibrosis and lower liver activity (95%CI: 3.5800-13.2519, P = 0.0001).CONCLUSION: LMP-7 SNP is a candidate gene that should be considered when designing a mathematical model for predicting response to therapy and disease progression in HCV patients. | Moataza H Omran Basma E Fotouh Samar S Youssef Noha E Ibrahim Wael Nabil EL-Sayed M Mahdy Wafaa G Shosha Mostafa K El-Awady | 2013 | World Journal of Hepatology2013，5，3： | 4 |
| 2 | Cyclic swelling behavior of clays显示文摘 | Al-Homoud A S Basma A A Malkawi A I H | 1995 | Journal of Geotechnical Engineering ASCE1995，121，7： | 1 |
| 3 | Cyclic Swelling behavior of Clays显示文摘 | A1-Homoud A S Basma A I H usein Malkawi A I | | 0，，07： | 1 |
| 4 | Differentiation arid transplantation of human embryonic stem cell-derived hepatocytes显示文摘 | Basma H Soto-Gutierrez A Yannam GR | 2009 | Gastroenterology2009，136，3： | 1 |
| 5 | Cyclic swelling behavior of clays显示文摘 | BASMA A A MALKAWI A I H | 1995 | J Geotech Eng1995，121，7： | 1 |
| 6 | Differentiation and transplantation of human em- bryonic stem cell-derived hepatocytes显示文摘 | BASMA H SOTO-GUTIERREZ A YANNAM G R | 2009 | Gastroenter- ology2009，136，： | 1 |
| 7 | Differentiation and transplantation of human embryonic stem cel-derived hepatocytes显示文摘 | Basma H Soto-Gutierrez A Yannam GR | | 0，，03： | 1 |
| 8 | Swelling - shrinkage behavior of natural expansive clays 显示文摘 | BASMA A A AL - HOMOUD A S MALKAWI A I H | 1996 | AppliedClay Science1996，11，24： | 1 |
| 9 | Reprogramming of COPD lung fibroblasts through formation of induced pluripotent stem cells 显示文摘 | Basma H Gunji Y Iwasawa S | 2014 | Am J Physiol Lung Cell Mol Physiol2014，306，6： | 1 |
| 10 | Activation of CMV promoter controlled glycosyhransferase and b-gal- actosidase glycogenes by butyrate, trichostatin A, and 5- Aza-29-deoxycytidine显示文摘 | CHOI K I-I BASMA H SINGH J | 2005 | Glycoeonjugate J2005，22，： | 1 |
| 11 | Swelling-shrinkage behavior of natural expansive clays显示文摘 | BASMA A A AL-HOMOUD A S MALKAWI A I H AL-BASHABSHEH M A | 1996 | Applied Clay Science1996，11，： | 1 |
| 12 | Cyclic Swelling Behavior of Clays 显示文摘 | AI-Homoud A S Basma A A Malkawi A I H | 1995 | Journal of Geotechnical Engineering ASCE1995，121，7： | 1 |
| 13 | Differentiation and transplantation of human embryonic stem cell-derived hepatocytes显示文摘 | Basma H Soto-Gutiérrez A Yannam GR Liu L Ito R Yamamoto T | 2009 | Gastroenterology2009，136，3： | 1 |
| 14 | Adaptability and configurability in cognitive radio design on small form factor software radio platform 显示文摘 | TACHWALI Y BASMA F REFAI H H | 2012 | Wireless Personal Communications2012，62，1： | 1 |
| 15 | Cyclic swelling behavior of clays显示文摘 | AL-HOMOUD A S BaSMA A A MALKAWI A I H BASHABSHEH M A | 1995 | Journal of Geotechnical Engineering ASCE1995，121，7： | 1 |
| 16 | Interobserver reliability of computed tomography angiography in the assessment of ruptured intracranial aneurysm and impact on patient management显示文摘BACKGROUND Aneurysmal subarachnoid hemorrhage is an emergency that can lead to a high mortality rate and many severe complications.It is critical to make a rapid radiological evaluation of ruptured intracranial aneurysms(RIAs)to determine the appropriate surgical treatment.AIM To assess the reliability of computed tomography angiography(CTA)in assessing different features of ruptured intracranial aneurysm and its impact on patient management.METHODS The final cohort of this study consisted of 146 patients with RIAs(75 male and 71 female)who underwent cerebral CTA.Their age ranged from 25 to 80,and the mean age±SD was 57±8.95 years.Two readers were asked to assess different features related to the aneurysm and perianeurysmal environment.Inter-observer agreement was measured using kappa statistics.Imaging data extracted from non-contrast computed tomography and CTA were considered to categorize the study population into two groups according to the recommended therapeutic approach.RESULTS The inter-observer agreement of both reviewers was excellent for the detection of aneurysms(K=0.95,P=0.001),aneurysm location(K=0.98,P=0.001),and(K=0.98,P=0.001),morphology(K=0.92,P=0.001)and margins(K=0.95,P=0.001).There was an excellent interobserver agreement for the measurement of aneurysm size(K=0.89,P=0.001),neck(K=0.85,P=0.001),and dome-to-neck ratio(K=0.98,P=0.001).There was an excellent inter-observer agreement for the detection of other aneurysm-related features such as thrombosis(K=0.82,P=0.001),calcification(K=1.0,P=0.001),bony landmark(K=0.89,P=0.001)and branch incorporation(K=0.91,P=0.001)as well as perianeurysmal findings including vasospasm(K=0.91,P=0.001),perianeurysmal cyst(K=1.0,P=0.001)and associated vascular lesions(K=0.83,P=0.001).Based on imaging features,87 patients were recommended to have endovascular treatment,while surgery was recommended in 59 patients.71.2%of the study population underwent the recommended therapy.CONCLUSION CTA is a reproducible promising diagnostic imaging modality for detecting and characterizing cerebral aneurysms. | Ali H Elmokadem Basma Abdelmonaem Elged Ahmed Abdel Razek Lamiaa Galal El-Serougy Mohamed Ali Kasem Mohamed Ali EL-Adalany | 2023 | World Journal of Radiology2023，15，6： | 0 |
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