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| 1 | Effects of Short-Term Forest Bathing on Human Health in a Broad-Leaved Evergreen Forest in Zhejiang Province,China显示文摘Objective To investigate the effects of short-term forest bathing on human health.Methods Twenty healthy male university students participated as subjects and were randomly divided into two groups of 10.One group was sent on a two-night trip to a broad-leaved evergreen forest,and the other was sent to a city area.Serum cytokine levels reflecting inflammatory and stress response,indicators reflecting oxidative stress,the distribution of leukocyte subsets,and plasma endothelin-1 (ET-1) concentrations were measured before and after the experiment to evaluate the positive health effects of forest environments.A profile of mood states (POMS) evaluation was used to assess changes in mood states.Results No significant differences in the baseline values of the indicators were observed between the two groups before the experiment.Subjects exposed to the forest environment showed reduced oxidative stress and pro-inflammatory level,as evidenced by decreased malondialdehyde,interleukin-6,and tumor necrosis factor α levels compared with the urban group.Serum cortisol levels were also lower than in the urban group.Notably,the concentration of plasma ET-1 was much lower in subjects exposed to the forest environment.The POMS evaluation showed that after exposure to the forest environment,subjects had lower scores in the negative subscales,and the score for vigor was increased.Conclusion Forest bathing is beneficial to human health,perhaps through preventive effects related to several pathological factors. | MAO Gen Xiang LAN Xiao Guang CAO Yong Bao CHEN Zhuo Mei HE Zhi Huat LV Yuan Dong WANG Ya Zhen HU Xi Lian WANG Guo Fu YAN Jing | 2012 | Biomedical and Environmental Sciences2012，25，3： | 20 |
| 2 | Neoadjuvant chemotherapy for locally advanced cervical cancer reduces surgical risks and lymph-vascular space involvement显示文摘Neoadjuvant chemotherapy(NACT),which can reduce the size and therefore increase the resectability of tumors,has recently evolved as a treatment for locally advanced cervical cancer.NACT has been reported to decrease the risk of pathologic factors related to prognosis of cervical cancer.To further assess the effects of NACT on surgery and the pathologic characteristics of cervical cancer,we reviewed 110 cases of locally advanced cervical cancer treated with radical hysterectomy with or without NACT at the People's Hospital of Peking University between January 2006 and December 2010.Of 110 patients,68 underwent platinum-based NACT prior to surgery(NACT group) and 42 underwent primary surgery treatment(PST group).Our results showed 48 of 68(70.6%) patients achieved a complete response or partial response to NACT.Estimated blood loss,operation time,and number of removed lymph nodes during surgery,as well as complication rates during and after surgery were not significantly different between the NACT group and the PST group.The rates of deep stromal invasion,positive parametria,positive surgical vaginal margins,and lymph node metastasis were not significantly different between the two groups.However,the rate of lymph-vascular space involvement(LVSI) was significantly lower in the NACT group than in the PST group(P = 0.021).In addition,the response rate of NACT was significantly higher in the patients with chemotherapeutic drugs administrated via artery than via vein.Our results suggest that NACT is a safe and effective treatment for locally advanced cervical cancer and significantly decreases the rate of LVSI. | Yue Wang Guang Wang Li-Hui Wei Ling-Hui Huang Jian-Liu Wang Shi-Jun Wang Xiao-Ping Li Dan-Hua Shen Dong-Mei Bao Jian Gao | 2011 | Chinese Journal of Cancer2011，30，9： | 18 |
| 3 | Establishment and preliminery use of hepatitis Bvirus preS1/2 antigen assay显示文摘 | CHEN Kun, HAN Bao Guang, MA Xian Kai, ZHANG He Qiu, MENG Li, WANG Guo Hua, XIA Fang, SONG Xiao Guo and LING Shi Gan | 1999 | World Journal of Gastroenterology1999，5，6： | 14 |
| 4 | Tree-ring-based May-July mean temperature history for Lüliang Mountains,China,since 1836显示文摘As a consequence of recent global warming and its social impact, regional climate change is attracting an increasing amount of attention from scientists. A May-July temperature proxy extending back to 1836 was developed from tree-ring width of Chinese pine (Pinus tabulaeformis Carr.) found in the middle Lüliang Mountains, northern China. Correlations with climatic data from six nearby meteorological stations range from -0.58 to -0.65, indicating a strong response of tree-ring index to May-July mean temperatures, which were subsequently reconstructed. The reconstruction captures 45% (F=38.474, P<0.001) of the regional variance in the instrumental data over the calibration period 1955-2003. Reconstructed warm and cold periods were verified by additional temperature reconstructions based on tree-ring data from northern China. In addition, the reconstruction was significantly corre-lated with May-July mean temperatures from 13 other meteorological stations in northern China, suggesting that our reconstruction is also representative of north-central China. The warming trend during the second half of the 20th century is seen in the reconstruction, but only the 1994-2002 mean temperature seems unprecedented over the whole reconstructed period. | CAI QiuFang LIU Yu BAO Guang LEI Ying SUN Bo | 2010 | Chinese Science Bulletin2010，55，26： | 12 |
| 5 | Allergy-related Evidences in Relation to Serum IgE:Data from the China State Key Laboratory of Respiratory Disease,2008-2013显示文摘Objective To investigate the serum total IgE(tlgE) and specific IgE(slgE) to common allergens among allergic patients in Guangzhou,China.Methods 7 085 patients were examined for tlgE and slgE to 15 allergens,based on the protocols of reversed enzyme allergosorbent test and the sandwich enzyme-linked immunosorbent assay.Results 3 758(53.04%) patients tested positive for tlgE,and 4 640(65.49%) for slgE.Der pteronyssinus,Der farinae,eggs,and cow's milk were the most common allergens leading to higher positive rates of slgE responses.Several peaks of sensitization were:Der pteronyssinus,Der farinae,and Blomia tropicalis at age 10-12;cow's milk at age below 3;eggs at age 4-6.The mean level and positive rate of tlgE tended to increase in subjects sensitized to more allergens.Sensitization to Der pteronyssinus(OR,1.6;P<0.05),Der farinae(OR,1.5;P<0.05),Blomia tropicalis(OR,1.4;P<0.05),Blattella germanica(OR,1.5;P<0.05),cow's milk(OR,1.3;P<0.05),and soy beans(OR,2.0;P<0.05) were independently correlated with allergy-related conditions in preliminary diagnosis.Conclusion The major allergens in Guangzhou include Der pteronyssinus,Der farinae,cow's milk,and eggs.Sensitization to these allergens appears to be predictors of allergy-related disorder. | SUN Bao Qing CHEN De Hui ZHENG Pei Yan HUANG Hui Min LUO Wen Ting ZENG Guang Qiao ZHANG Xiao Wen | 2014 | Biomedical and Environmental Sciences2014，27，7： | 11 |
| 6 | Mycoplasma pneumoniae Macrolide Resistance and MLVA Typing in Children in Beijing,China,in 2016:Is It Relevant?显示文摘Objective The aim of this study is to investigate the macrolide resistance rate and molecular type with multiple-locus variable-number tandem-repeat analysis(MLVA)of Mycoplasma pneumoniae of Beijing in 2016 in pediatric patients.Methods Real-time quantitative polymerase chain reaction(PCR)was used to identify M.pneumoniae,and MLVA was performed.The domain V of the 23 S rRNA was sequenced to detect macrolide-resistant point mutations.We also investigated the activities of antibiotics against M.pneumoniae isolates in vitro.Results The PCR detection rate of M.pneumoniae in children in Beijing was 40%,and the macrolide resistance rate was 66%.The A2063 G mutation in the 23 S rRNA V region is the dominant mutation(137/146,93.84%),whereas the A2064 G mutation is rare(9/146,6.16%).Seventy-three samples were typed successfully by MLVA typing,including 86.3%(63/73)were MLVA type 4-5-7-2,and 13.7%(10/73)were MLVA type 3-5-6-2.No other types were found.No strains were resistant to levofloxacin or tetracycline.Conclusion In 2016,a specific decrease in the macrolide resistance rate occurred in Beijing.The detection rate and macrolide resistance rate of outpatients are lower than those of inpatients.The A2063 G mutants M.pneumoniae have high levels of resistance to erythromycin and azithromycin.The primary MLVA type is 4-5-7-2,followed by 3-5-6-2.No other MLVA types were detected.No strains resistant to tetracycline or levofloxacin were found in vitro. | DOU Hai Wei TIAN Xiu Jun XIN De Li WEI Ran ZHOU Wei WANG Hong QIN Xuan Guang SHAO Jun Yan XU Bao Ping GE Li Xia SHI Da Wei | 2020 | Biomedical and Environmental Sciences2020，33，12： | 9 |
| 7 | A tree-ring-based reconstruction of the Yimin River annual runoff in the Hulun Buir region,Inner Mongolia,for the past 135 years显示文摘Based on the relationships between the regional tree-ring chronology(RC) of moisture-sensitive Pinus sylvestris var.mongolica and the monthly mean maximum temperature,annual precipitation and annual runoff,a reconstruction of the runoff of the Yimin River was performed for the period 1868-2002.The model was stable and could explain 52.2% of the variance for the calibration period of 1956-2002.During the past 135 years,21 extremely dry years and 19 extremely wet years occurred.These years represented 15.6% and 14.1% of the total study period,respectively.Six severe drought events lasting two years or more occurred in 1950-1951,1986-1987,1905-1909,1926-1928,1968-1969 and 1919-1920.Four wetter events occurred during 1954-1959,1932-1934,1939-1940 and 1990-1991.Comparisons with other tree-ring-based streamflow reconstructions or chronologies for surrounding areas supplied a high degree of confidence in our reconstruction.Power spectrum and wavelet analyses suggested that the reconstructed annual runoff variation in the Hulun Buir region and surrounding area could be associated with large-scale atmospheric-oceanic variability,such as the Pacific Decadal Oscillation(PDO) and El Ni o-Southern Oscillation(ENSO),and sunspot activity. | BAO Guang LIU Yu LIU Na | 2012 | Chinese Science Bulletin2012，57，36： | 9 |
| 8 | Micro/nano-structured TiO2 surface with dual-functional antibacterial effects for biomedical applications显示文摘Implant-associated infections are generally difficult to cure owing to the bacterial antibiotic resistance which is attributed to the widespread usage of antibiotics.Given the global threat and increasing influence of antibiotic resistance,there is an urgent demand to explore novel antibacterial strategies other than using antibiotics.Recently,using a certain surface topography to provide a more persistent antibacterial solution attracts more and more attention.However,the clinical application of biomimetic nano-pillar array is not satisfactory,mainly because its antibacterial ability against Gram-positive strain is not good enough.Thus,the pillar array should be equipped with other antibacterial agents to fulfill the bacteriostatic and bactericidal requirements of clinical application.Here,we designed a novel model substrate which was a combination of periodic micro/nano-pillar array and TiO2 for basically understanding the topographical bacteriostatic effects of periodic micro/nano-pillar array and the photocatalytic bactericidal activity of TiO2.Such innovation may potentially exert the synergistic effects by integrating the persistent topographical antibacterial activity and the non-invasive X-ray induced photocatalytic antibacterial property of TiO2 to combat against antibiotic-resistant implant-associated infections.First,to separately verify the topographical antibacterial activity of TiO2 periodic micro/nano-pillar array,we systematically investigated its effects on bacterial adhesion,growth,proliferation,and viability in the dark without involving the photocatalysis of TiO2.The pillar array with sub-micron motif size can significantly inhibit the adhesion,growth,and proliferation of Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli).Such antibacterial ability is mainly attributed to a spatial confinement size-effect and limited contact area availability generated by the special topography of pillar array.Moreover,the pillar array is not lethal to S.aureus and E.coli in 24 h.Then,the X-ray induced photocatalytic antibacterial property of TiO2 periodic micro/nano-pillar array in vitro and in vivo will be systematically studied in a future work.This study could shed light on the direction of surface topography design for future medical implants to combat against antibiotic-resistant implant-associated infections without using antibiotics. | Xiang Ge Chengzu Ren Yonghui Ding Guang Chen Xiong Lu Kefeng Wang Fuzeng Ren Meng Yang Zhuochen Wang Junlan Li Xinxin An Bao Qian Yang Leng | 2019 | Bioactive Materials2019，4，1： | 8 |
| 9 | Magnetic Resonance Imaging and Histopathological Analysis of Experimental Muscle Injuries in a Rabbit显示文摘Objective To investigate the correlation of magnetic resonance imaging(MRI) with histopathological changes,and to evaluate T2mapping in assessing muscle trauma in a rabbitmodel of muscle injury.Methods We divided 35 rabbits into seven groups that each represented a different time point after intramuscular hemorrhage and muscle injury.Hemorrhage was created by injecting autologous blood into the left legs,and muscle injury was created by scalpel incision of the biceps femoris of the right legs.At different time points,the rabbits underwent T1-weighted imaging and T2-weighted imaging(T1WI and T2WI) and T2mapping.T2relaxation times were measured,and the corresponding samples were evaluated for pathological changes.Results After 2 h,the intramuscular hemorrhage model demonstrated an increased signal intensity on both T1WI and T2WI.Histological examination showed erythrocytes within the muscle bundle.On days 1and 3,the MRI signals were decreased,and there were no significant changes after day 7.From 2 h to 3days,the muscle-injury model showed a high signal on both T1WI and T2WI.Corresponding pathological changes included rupture and edema of muscle fibers,and inflammation.The abnormal signals were reduced on day 7.After day 14,the T2WI intensity remained high.T1WI showed no abnormal changes,but some models showed a high signal,representing fresh bleeding and fatty tissue.T2relaxation times were significantly different between the central and marginal regions,and between the marginal and normal regions.Conclusion MRI clearly demonstrates intramuscular hemorrhage and muscle injury,which correlate well with histopathological changes.T2mapping is useful in assessing the extent of injury. | YAN Dong ZHANG Jing LIANG Wei SUN Jing LIU Bao Yue TIAN Wei CHENG Xiao Guang | 2013 | Biomedical and Environmental Sciences2013，26，10： | 7 |
| 10 | The Lyman-alpha Solar Telescope(LST) for the ASO-S mission——Ⅱ. design of LST显示文摘As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,respectively.The maximum exposure time can be up to20 s due to precise pointing and image stabilization function.Among the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attain<10^-6 B⊙(B⊙is the mean brightness of the solar disk)at 1.1 R⊙and≤5×10^-8 B⊙at 2.5 R⊙.SDI and WST are solar disk imagers working in the Lyαline and 360.0 nm wavebands,respectively,which adopt an off-axis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal imaging.We present the up-to-date design for the LST payload. | Bo Chen Hui Li Ke-Fei Song Quan-Feng Guo Pei-Jie Zhang Ling-Ping He Shuang Dai Xiao-Dong Wang Hai-Feng Wang Chun-Long Liu Hong-Ji Zhang Guang Zhang Yunqi Wang Shi-Jie Liu Hong-Xin Zhang Lei Liu Shi-Lei Mao Yang Liu Jia-Hao Peng Peng Wang Liang Sun Yang Liu Zhen-Wei Han Yan-Long Wang Kun Wu Guang-Xing Ding Peng Zhou Xin Zheng Ming-Yi Xia Qing-Wen Wu Jin-Jiang Xie Ya Chen Shu-Mei Song Hong Wang Bo Zhu Chang-Bo Chu Wen-Gang Yang Li Feng Yu Huang Wei-Qun Gan Ying Li Jing-Wei Li Lei Lu Jian-Chao Xue Bei-Li Ying Ming-Zhe Sun Cheng Zhu Wei-Min Bao Lei Deng Zeng-Shan Yin | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 6 |
| 11 | Effects of Structural Changes in Subchondral Bone on Articular Cartilage in a Beagle Dog Model显示文摘Objective Using MR T2-mapping and histopathologic score for articular cartilage to evaluate the effect of structural changes in subchondral bone on articular cartilage. Methods Twenty-four male Beagle dogs were randomly divided into a subchondral bone defect group(n = 12) and a bone cement group(n = 12). Models of subchondral bone defectin the medial tibial plateau and subchondral bone filled with bone cement were constructed. In all dogs, the left knee joint was used as the experimental sideand the right knee as the sham side. The T2 value for articular cartilage at the medial tibial plateau was measured at postoperative weeks 4, 8, 16, and 24. The articular cartilage specimens were stained with hematoxylin and eosin, and evaluated using the Mankin score. Results There was a statistically significant difference(P < 0.05) in Mankin score between the bone defect group and the cement group at postoperative weeks 16 and 24. There was a statistically significant difference in the T2 values between the bone defect group and its sham group(P < 0.05) from week 8, and between the cement group and its sham group(P < 0.05) from week 16. There was significant difference in T2 values between the two experimental groups at postoperative week 24(P < 0.01). The T2 value for articular cartilage was positively correlated with the Mankin score(ρ = 0.758, P < 0.01). Conclusion Structural changes in subchondral bone can lead to degeneration of the adjacent articular cartilage. Defects in subchondral bone cause more severe degeneration of cartilage than subchondral bone filled with cement. The T2 value for articular cartilage increases with the extent of degeneration. MR T2-mapping images and the T2 value for articular cartilage can indicate earlycartilage degeneration. | YAN Dong LIU Tong Xi LIU Bao Yue WANG Ling QIAN Zhan Hua CHENG Xiao Guang LI Kun Cheng | 2017 | Biomedical and Environmental Sciences2017，30，3： | 4 |
| 12 | Triboelectric nanogenerator enhanced multilayered antibacterial nanofiber air filters for efficient removal of ultrafine particulate matter显示文摘我们开发了 multilayered 抗菌剂 polyimide (PI ) nanofiber 空气为把极其细小的微粒物质(下午) 从周围的空气移开过滤的提高的高效率的旋转摩擦电 nanogenerator (R-TENG ) 。比作单人赛分层的 PI nanofiber 过滤器, multilayered nanofiber 过滤器能完全与比 0.54 m 大的直径粒子移开所有,表演为更小的下午粒子提高移动效率。在与 aR-TENG 连接以后,为极其细小的粒子的 filer 的移动效率进一步被提高。为极其细小的微粒物质的最高的移动效率在 53.3 nm 的直径是 94.1% ,平均移动效率到达 89.9% 。尽管有层数字的增加,这部电影的每单个层的厚度减少了,并且因此,过滤器的全部的压力落下减少了而不是增加。而且,因为银 nanoparticles 的小数量的增加, nanofiber 电影展出了高抗菌剂活动。有零个臭氧版本和低压力落下的这种技术为清洗空气,薄雾处理,和细菌的控制是适当的。 | Guang Qin Gu Chang Bao Han Jing Jing Tian Tao Jiang Chuan He Cun Xin Lu Yu Bai Jin Hui Nie Zhou Li Zhong Lin Wang | 2018 | Nano Research2018，11，8： | 4 |
| 13 | A New Type of Polymer-Supported Metallocene Catalyst for Ethylene Polymerization显示文摘A new polymer-supported metallocene catalyst has been prepared. The polymer- supported metallocene displayed considerably high activity in ethylene polymerization, the highest being 3.62(107gPE/molZr(h, the molecular weight of the polyethylene produced was Mn = 1.29(105, about 3-4 times those of corresponding homogeneous zirconocenes. The polymer- supported metallocene keeps the characteristics of homogeneous metallocene catalysts, and offers some features,such as adaptable to gas phase and slurry processes; easy to prepare in low cost; relatively high activity and lower MAO/Zr ratio; lower inorganic residues in the polyolefins as compared to cases of SiO2, Al2O3 or MgCl2; unitary active structure, no complex surface as with SiO2; good control of morphology of the resulting polymer. | Guang Qian YU*, De Ze ZHANG, Fu SHUN, Li Jun QIAO,Tao TANG, Bao Tong HUANG State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences Polymer Chemistry Laboratory, Chemistry Academy of S | 2001 | Chinese Chemical Letters2001，12，3： | 4 |
| 14 | Integrative square-grid triboelectric nanogenerator as a vibrational energy harvester and impulsive force sensor显示文摘方形格子的摩擦电 nanogenerator (SG-TENG ) 为收获震动的精力并且察觉到冲动的力量被表明。每个广场三维(3D ) 打印了方形的格子充满铝(艾尔) 球。格子结构允许 SG-TENG 在宽广带宽上收获震动的精力并且在不同震动的角度操作。SG-TENG 的最惹人注目的特征是它被放大的能力并且综合。在在平行连接二 SG-TENGs 以后,开电路的电压和电线走火电流显著地在完整的震动的频率范围上被增加。与一个乒乓球球拍是综合的, SG-TENG 能从用球拍击一个砰恶臬球收获震动的精力,在由球拍的直接命中产生一般水准的地方,输出 10.9 | Chuan He Weijun Zhu Guang Qin Gu Tao Jiang Liang Xu Bao Dong Chen Chang Bao Han Dichen Li Zhong Lin Wang | 2018 | Nano Research2018，11，2： | 3 |
| 15 | Flavokawain B alleviates LPS-induced acute lung injury via targeting myeloid differentiation factor 2显示文摘Acute lung injury(ALI)is a sudden onset systemic inflammatory response.ALI causes severe morbidity and death and currently no effective pharmacological therapies exist.Natural products represent an excellent resource for discovering new drugs.Screening anti-inflammatory compounds from the natural product bank may offer viable candidates for molecular-based therapies for ALI.In this study,165 natural compounds were screened for anti-inflammatory activity in lipopolysaccharide(LPS)-challenged macrophages.Among the screened compounds,flavokawain B(FKB)significantly reduced LPS-induced pro-inflammatory IL-6 secretion in macrophages.FKB also reduced the formation of LPS/TLR4/MD2 complex by competitively binding to MD2,suppressing downstream MAPK and NF-κB signaling activation.Finally,FKB treatment of mice reduced LPS-induced lung injury,systemic and local inflammatory cytokine production,and macrophage infiltration in lungs.These protective activities manifested as increased survival in the ALI model,and reduced mortality upon bacterial infection.In summary,we demonstrate that the natural product FKB protects against LPS-induced lung injury and sepsis by interacting with MD2 and inhibiting inflammatory responses.FKB may potentially serve as a therapeutic option for the treatment of ALI. | Wu Luo Li-bin Yang Chen-chen Qian Bao Ma Gloria MManjengwa Xiao-min Miao Jie Wang Cheng-hong Hu Bo Jin Ling-xi Zhang Chao Zheng Guang Liang Yi Wang | 2022 | Acta Pharmacologica Sinica2022，43，7： | 2 |
| 16 | Research on the Impact of AGC Vibration on the Horizontal Vibration of the Roll System for CSP Rolling Mill显示文摘 | Yan Xiao Qiang Bao Miao Zhu Guang Hong Song Ze Hong | 2010 | Advanced Materials Research2010，，139： | 1 |
| 17 | The Design and Application of Sewage Treatment Automation System Based on $7-300 PLC显示文摘 | Bai Jing-Jing Zhao Zi-Xian Bao Chun-Hong Feng Shi- Guang | 2011 | Applied In- formaties and Corn munication2011，，225： | 1 |
| 18 | A p53/CPEB2 negative feedback loop regulates renal cancer cell proliferation and migration显示文摘The tumor suppressor p53 transactivates the expression of multiple genes to exert its multifaceted functions and ultimately maintains genome stability.Thus,cancer cells develop various mechanisms to diminish p53 expression and bypass the cell cycle checkpoint.In this study,we identified the gene encoding RNAbinding protein cytoplasmic polyadenylation element-binding protein 2(CPEB2)as a p53 target.In turn,CPEB2 decreases p53 messenger RNA stability and translation to fine-tune p53 level.Specifically,we showed that CPEB2 binds the cytoplasmic polyadenylation elements in the p5330-untranslated region,and the RNA recognition motif and zinc finger(ZF)domains of CPEB2 are required for this binding.Furthermore,we found that CPEB2 was upregulated in renal cancer tissues and promotes the renal cancer cell proliferation and migration.The oncogenic effect of CPEB2 is partially dependent on negative feedback regulation of p53.Overall,we identify a novel regulatory feedback loop between p53 and CPEB2 and demonstrate that CPEB2 promotes tumor progression by inactivating p53,suggesting that CPEB2 is a potential therapeutic target in human renal cancer. | Jiehui Di Guang Zhao Hui Wang Yaoyao Wu Zhongjun Zhao Bao Zhu Yanping Zhang Junnian Zheng Yong Liu Ying Hu | 2021 | Journal of Genetics and Genomics2021，48，7： | 1 |
| 19 | Effects of Propofol on the Outcomes of Rats with gepsis显示文摘 | HONG GUANG BAO SHALI | 2011 | Journal of gurglcal Re- search2011，168，1： | 1 |
| 20 | Total Synthesis of Three New Dihydrostilbenes from Bulbophllum odoratissimum显示文摘A total synthesis of three new dihydrostilbenes, 1, 2 and 3, which were isolated from Bulbophyllum odoratissimum Lindl. with significant cytotoxicity toward human cancer cell lines, was developed via Horner reaction etc. The natural products 1, 2 and 3 were obtained in 5.8%, 6.6% and 5.9%, respectively. | Jin Guang LIN Wei Ge ZHANG Rui ZHAO Ze Yu NIU Kai BAO Dai Lin LIU Nai Li WANG Xin Shen YAO | 2006 | Chinese Chemical Letters2006，17，3： | 1 |
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