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| 1 | Role of PRMTs in cancer: Could minor isoforms be leaving a mark?显示文摘Protein arginine methyltransferases(PRMTs) catalyze the methylation of a variety of protein substrates, many of which have been linked to the development, progression and aggressiveness of different types of cancer. Moreover, aberrant expression of PRMTs has been observed in several cancer types. While the link between PRMTs and cancer is a relatively new area of interest, the functional implications documented thus far warrant further investigations into its therapeutic potential. However, the expression of these enzymes and the regulation of their activity in cancer are still significantly understudied. Currently there are nine main members of the PRMT family. Further, the existence of alternatively spliced isoforms for several of these family members provides an additional layer of complexity. Specifically, PRMT1, PRMT2, CARM1 and PRMT7 have been shown to have alternative isoforms and others may be currently unrealized. Our knowledge with respect to the relative expression and the specific functions of these isoforms is largely lacking and needs attention. Here we present a review of the current knowledge of theknown alternative PRMT isoforms and provide a rationale for how they may impact on cancer and represent potentially useful targets for the development of novel therapeutic strategies. | R Mitchell Baldwin Alan Morettin Jocelyn C té | 2014 | World Journal of Biological Chemistry2014，5，2： | 14 |
| 2 | The eco-physiological complexity of plant responses to insect herbivores显示文摘 | BALDWIN I T PRESTON C A | 1999 | Planta1999，208，： | 2 |
| 3 | Temperature of water heat treatments influences tomato fruit quality following low-temperature storage显示文摘 | MEDONALD R E MECOLLUM T G BALDWIN E A | 1999 | Postharvest Biology and Technology1999，16，： | 1 |
| 4 | Immunological 'memory' in the induced accumulation of nicotine in wild tobacco 显示文摘 | BALDWIN I T SCHMELZ E A | 1999 | Ecology1999，77，1： | 1 |
| 5 | Deep lexical acquisition of verb particle constructions显示文摘 | Baldwin T | 2005 | Computer Speech and Language Special Issue on Multiword Expressions2005，19，4： | 1 |
| 6 | Multiword Expres- sions: A Pain in the Neck for NLP显示文摘 | SAG I BALDWIN T BOND F | 2002 | Computational Lin- guistics and Intelligent Text Processing2002，，： | 1 |
| 7 | Stimulation of feeding in the satiated pig by intracerebroventricular injection of NPY显示文摘 | Parrott R T Heavens R P Baldwin B A | 1986 | Physiology and Behavori1986，36，： | 1 |
| 8 | Nitrogen supply influences herbivore-induced direct and indirect defenses and transcriptional responses in Nicotiana attenuate 显示文摘 | Lou Y G Baldwin I T | 2004 | Plant Physiology2004，135，： | 1 |
| 9 | An effective method for evaluating the accuracy of power hardware in-the-loop simulations显示文摘 | WEI R STEURER M BALDWIN T L | 2009 | IEEE Trans on Industry Applications2009，45，4： | 1 |
| 10 | DNA assembly for synthetic biology: from parts to pathways and beyond 显示文摘 | Ellis T Adie T Baldwin G S | 2011 | Integrative Biology2011，3，2： | 1 |
| 11 | Power system observability with minimal phasor measurement placement 显示文摘 | Baldwin T L Mili L Boisen M B | 1993 | IEEE Trans on Power Systems1993，8，2： | 1 |
| 12 | Allocation of ^15N from nitrate to nicotine: production and turnover of a damage-induced mobile defense显示文摘 | Ian T Baldwin Eric A Schmeh | 1994 | Ecology1994，75，9： | 1 |
| 13 | The social fabric of a team based MBA program显示文摘 | Baldwin T T Bedell M D Johnson J L | | 0，，06： | 1 |
| 14 | A pilot randomized controlled comparison of extended daily dialysis with filtration and continu- ous veno-venous hemofiltration:fluid removal and hemodynamics显示文摘 | Baldwin I Bellomo R Naka T | 2007 | The International journal of artificial organs2007，30，12： | 1 |
| 15 | A biomechanical analysis of treatment options for enchondromas of the hand 显示文摘 | Pianta T J Baldwin PS Obopilwe E | 2013 | Hand (NY)2013，8，1： | 1 |
| 16 | Relationships among defoliation, red oak phenolics, and gypsy moth growth and reproduction 显示文摘 | KIDD N A C LEWIS G B BALDWIN I T | 1985 | Ecology1985，10，： | 1 |
| 17 | Communication between plant: induced resistance in wild tobacco plant following clipping of neighboring sagebrush显示文摘 | KARBAN R BALDWIN I T BAXTER K J | 2000 | Oecologia2000，125，： | 1 |
| 18 | Herbivoreinduced allene oxide synthase transcripts and jasmonic acid in Nicotiana attenuata显示文摘 | JORG ZIEGLER MARKKU KEINANEN IAN T BALDWIN | 2001 | Phytochemistry2001，58，： | 1 |
| 19 | Reactive-power compensation for voltage control at resistance welders显示文摘 | BALDWIN T L HOGANS T JR HENRY S D | 2005 | IEEE Transactions on Industry Applications2005，41，6： | 1 |
| 20 | Power system observability with minimal phasor measurement placement显示文摘 | Baldwin T L Mili L Boisen M B | 1993 | IEEE Transactions on Power Systems1993，8，2： | 1 |
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