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| 1 | Role of PRMTs in cancer: Could minor isoforms be leaving a mark?显示文摘Protein arginine methyltransferases(PRMTs) catalyze the methylation of a variety of protein substrates, many of which have been linked to the development, progression and aggressiveness of different types of cancer. Moreover, aberrant expression of PRMTs has been observed in several cancer types. While the link between PRMTs and cancer is a relatively new area of interest, the functional implications documented thus far warrant further investigations into its therapeutic potential. However, the expression of these enzymes and the regulation of their activity in cancer are still significantly understudied. Currently there are nine main members of the PRMT family. Further, the existence of alternatively spliced isoforms for several of these family members provides an additional layer of complexity. Specifically, PRMT1, PRMT2, CARM1 and PRMT7 have been shown to have alternative isoforms and others may be currently unrealized. Our knowledge with respect to the relative expression and the specific functions of these isoforms is largely lacking and needs attention. Here we present a review of the current knowledge of theknown alternative PRMT isoforms and provide a rationale for how they may impact on cancer and represent potentially useful targets for the development of novel therapeutic strategies. | R Mitchell Baldwin Alan Morettin Jocelyn C té | 2014 | World Journal of Biological Chemistry2014，5，2： | 14 |
| 2 | The eco-physiological complexity of plant responses to insect herbivores显示文摘 | BALDWIN I T PRESTON C A | 1999 | Planta1999，208，： | 2 |
| 3 | Managing in an Age of Modularity显示文摘 | Baldwin C Y Clark K B | 1997 | Harvard Business Review1997，75，5： | 1 |
| 4 | VEGF-D promotes spread of tumor cells via the lymphatic显示文摘 | Stacker SA Caesar C Baldwin ME | 2004 | Nat Med2004，7，2： | 1 |
| 5 | Managing in an age of modularity显示文摘 | Baldwin C Clark K | 1997 | Harvard Business Review1997，75，5： | 1 |
| 6 | 显示文摘 | Adler J Baldwin P M Melia C D | 1994 | Starch1994，46，7： | 1 |
| 7 | Accelerated corrosion test for aerospace materials: current limitation and future trends 显示文摘 | Baldwin K G Smith C F E | 1999 | Aircraft Engineering and Aerospace Technology1999，71，3： | 1 |
| 8 | Immunogenicity and protective efficacy of DNA vaccines encoding secreted and non - secreted forms of Mycobacterium tuberculosis Ag85A 显示文摘 | BaldwinS L Dsouza C D Orme I M | 1999 | Tuber Lung Dis1999，79，4： | 1 |
| 9 | Managing in an age of modularity显示文摘 | BALDWIN C Y CLARK K B | 1997 | Harvard Business Review1997，75，5： | 1 |
| 10 | VEGF-D promotes the metastasis spread of tumor cells via the lymphatics显示文摘 | Stacker SA Caesar C Baldwin ME | 2001 | Nat Med2001，7，2： | 1 |
| 11 | VEGF-D promotes the metastatic spread of tumor cells via the lymphatics显示文摘 | Caesar C Baldwin ME | 2001 | Nat Med2001，7，2： | 1 |
| 12 | Is subcortical disease associated with a poor response to antidepressants? Neurological,neuropsychological and neuroradiological findings in late-life depression显示文摘 | Simpson S Baldwin R C Jackson A | 1998 | Psychol Med1998，28，5： | 1 |
| 13 | Evidence that some preganglionic sympathetic neurons in the rat contain vasoactive intestinal peptide- or peptide histidine isoleucine amide-like immunoreactivities显示文摘 | Baldwin C Sasek CA Zigmond RE | 1991 | Neuroscience1991，40，1： | 1 |
| 14 | Structural testing of navy vessels using Bragg gratings and a prototype digital spatial wavelength domain multiplexing system 显示文摘 | Baldwin C Miemczuk J Kiddy J | 2002 | AVAL Engineers Journal2002，114，： | 1 |
| 15 | The amount of small-group casestudy discussion needed to improve moral reasoning skills of medical students显示文摘 | I SELF D J OLIVAREZ M BALDWIN D C | 1998 | Acad Med1998，73，5： | 1 |
| 16 | Starch damage part 1 : Characterization of granule damage in ball-milled potato starch study by SEM 显示文摘 | Baldwin P M Adler J Davies M C | 1995 | Starch1995，47，： | 1 |
| 17 | Topical negative pressure stimulates endothelial migration and proliferation: a suggested mechanism for improved integration of integra显示文摘 | Baldwin C Potter M Clayton E | 2009 | Ann Plast Surg2009，62，1： | 1 |
| 18 | Managing in an age of modularity显示文摘 | BALDWIN C Y CLARK K B | 1997 | Harvard Business Review1997，75，5： | 1 |
| 19 | Sequence and structure of a human glucose transporter显示文摘 | Mueckler M Caruso C Baldwin SA | 1985 | Science1985，229，： | 1 |
| 20 | Growth factor in corneal wound healing following refractive surgery:a review显示文摘 | BALDWIN H C MARSHALL J | 2002 | Acta Ophthalmol Scand2002，80，3： | 1 |
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