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| 1 | Human sperm immobilization effect of Carica papaya seed extracts: an in vitro study显示文摘Aim: To examine if the seed extracts of Carica papaya, which showed antispermatogenic/sperm immobilization properties in animal models, could cause human sperm immobilization in vitro. Methods: Chloroform extract, benzene chromatographic fraction of the chloroform extract, its methanol and ethyl acetate sub-fractions and the isolated compounds from the sub-fractions i.e., ECP 1 & 2 and MCP 1 & 2, of the seeds of Cadca papaya were used at concentrations of 0.1%, 0.5%, 1% and 2%. Sperm motility was assessed immediately after addition of extracts and every 5 minutes thereafter for 30 minutes. Results: There were dose-dependent spermicidal effects showing an instant fall in the sperm motility to less than 20 % at 2 % concentration. Isolated compounds ECP 1 & 2 were more effective inducing a motility of less than 10%. Many of the spermatozoa became vibratory on the spot. Total inhibition of motility was observed within 20 - 25 min at all concentrations of all products. Scanning and transmission electron microscopy revealed deleterious changes in the plasma membrane of the head and mid-piece of spermatozoa. Sperm viability test and the number of abnormal spermatozoa after completion of incubation suggested that the spermatozoa were infertile. The effects were spermicidal but not spermiostatic as revealed by the sperm revival test. Conclusion: The results reveal spermicidal activity in vitro of the seed extracts of Carica papaya. | Nirmal K Lohiya Lalit K Kothari B Manivannan Pradyumna K Mishra Neelam Pathak | 2000 | Asian Journal of Andrology2000，2，2： | 6 |
| 2 | Characterization of non-amine-based post-copper chemical mechanical planarization cleaning solution显示文摘 | MANIVANNAN R CHO B J HAILIN X | 2014 | Microelectronic Engineering2014，122，： | 1 |
| 3 | Paclobutrazol enhances photosynthesis and ajmalicine production in C(tharanghus roseus显示文摘 | Jaleel C A Manivannan P Sankar B | 2007 | Process Biochem2007，42，11： | 1 |
| 4 | Studies on germination, seedling vigour, lipid peroxidation and proline metabolism in Catharanthus roseus seedlings under salt stress显示文摘 | Jaleel CA Gopi R Sankar B Manivannan P Kishorekumar A Sridharan R | 2007 | South Afr J Bot2007，73，2： | 1 |
| 5 | Water deficit stress mitigation by calcium chloride in Catkaranthu3 roseu3 : effects on oxidative stress, prolinc metabolism and indole alkaloid accumulation 显示文摘 | Jaleel C A Manivannan P Sankar B | 2007 | Colloids and Surfaces B : Biointerfaces2007，60，： | 1 |
| 6 | Electrochemi cal capacitors with KC1 eletrolyte显示文摘 | Lee H Y Manivannan V Goodenough J B | 1999 | C R Acad Sci Ser IIc:Chim1999，2，11： | 1 |
| 7 | Pseudo- monas fluorescens enhances biomass yield and ajmalicine production in Catharanthas roseus under water deficit stress 显示文摘 | Jaleel C A Manivannan P Sankar B | 2007 | Colloids Surf B2007，60，： | 1 |
| 8 | Cathodes for lithium-ion batteries:some comparisons显示文摘 | MANIVANNAN V | 1998 | Denki Kagaku1998，66，12： | 1 |
| 9 | Electrochemical capacitors with KCl electrolyte显示文摘 | MANIVANNAN V GOODENOUGH J B | 1999 | Acaé mie des sciences1999，11，： | 1 |
| 10 | Al- terations in osmoregulation,antioxidant enzymes and indole alkaloid levels in Catharanthus roseus exposed to water deficit显示文摘 | JALEEL C A MANIVANNAN A KISHOREKUMAR A SANKAR B GOPI R SOMASUNDARAM R PANNEERSELVAM R | 2007 | Colloids and Surfaces B: Biointerfaces2007，59，1： | 1 |
| 11 | Tuning the position of the redox couples in materials with NA- SICON structure by anionic substitution显示文摘 | Padhi A K Manivannan V Goodenough J B | 1998 | J Electro- chem Soc1998，145，： | 1 |
| 12 | Citrate-gel synthesis and characterization of Y-doped BiFeO3 显示文摘 | Bellakki M B Manivannan V | 2010 | J Sol- Gel Technology2010，53，2： | 1 |
| 13 | Status of spermatogenesis and sperm parameters in langnr monkeys following longterm vas occlusion with styrene maleic anhydride显示文摘 | Mishra PK Manivannan B Pathak N | 2004 | Androl2004，24，4： | 1 |
| 14 | Calcium chloride effects on salinity-induced oxidative stress,proline metabolism and indole alkaloid accumulation in Catharanthus roseus显示文摘 | Abdul Jaleel C Manivannan P Sankar B | 2007 | Comptes Rendus Biologies2007，330，9： | 1 |
| 15 | Magnetism of Co-doped titania thin films prepared by spray pyrolysis显示文摘 | Manivannan A Seehra M S Majumder S B | 2003 | Appl Phys Lett2003，83，1： | 1 |
| 16 | Understanding water deficit stress-induced changes in the basic metabolism of higher plants-biotechnologically and sustainably improving agriculture and the ecoenvironment in arid regions of the globe显示文摘 | SHAO H B CHU L Y JALEEL C A Manivannan P Panneerselvam R and Shao M A | 2009 | Critical Reviews on Biotechnology2009，29，： | 1 |
| 17 | Tuning the position of the redox couples in materials with NA- SICON structure by anionic subsitiution 显示文摘 | Goodenough J B Manivannan V Padhi A K | 1998 | J Elect- rochem Soc1998，145，5： | 1 |
| 18 | Tuning the Position of the Redox Couples in Materials with NASICON Struc ture by Anionic Substitution显示文摘 | Padhi A K Manivannan V Goodenough J B | 1998 | Journal of the Electrochemical Society1998，145，5： | 1 |
| 19 | Inducing of droughtstress tolerance by detoconazole in Catharanthus roseus in mediated byenhanced antioxidant potentials and secondary metabolite accumulation显示文摘 | JALEEL C A MANIVANNAN P SANKAR B | 2007 | Colloids and Surfaces B:Biointerfaces2007，60，： | 1 |
| 20 | Magnetism of Co - doped titania thin films prepared by spray pyrolysis 显示文摘 | MANIVANNAN A SEEHRA M S MAJUMDER S B et al | 2003 | Appl Phys Lett2003，83，： | 1 |
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