|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impact of postoperative omega-3 fatty acid-supplemented parenteral nutrition on clinical outcomes and immunomodulations in colorectal cancer patients显示文摘AIM: To investigate the effect of omega-3 fatty acid parenteral supplementation postoperatively on clinical outcomes and immunomodulation in colorectal cancer patients. METHODS: Forty-two patients undergoing radical colorectal cancer resection with an indication for total parenteral nutrition postoperatively were enrolled in this prospective, double-blind, randomized, controlled study. Patients received total parenteral nutrition supplemented with either soybean oil (LCT; Intralipid, Fresenius-Kabi, SO group, n = 21) or a combination of omega-3 fish oil and soybean oil (LCT:fish oil = 5:1, fish oil; Omegaven, Fresenius-Kabi, FO group, n = 21), up to a total of 1.2 g lipid/kg per day for 7 d postoperatively. A same volume calorie and nitrogen was administrated. Routine blood test, biochemistry, systemic levels of IL-6 and TNF-α, percentage of CD3+, CD4+, and CD8+ lymphocytes were evaluated preoperatively and on postoperative d 1 and 8. Patient outcome was evaluated considering mortality during the hospital stay, length of postoperative hospital stay, and occurrence of infectious complications. RESULTS: Both lipid regimens were well tolerated. No differences between the two groups were noticed in demographics, baseline blood test, biochemistry, serum levels of IL-6 and TNF-α, percentage of CD4+, CD8+ lymphocytes, and ratios of CD4+/CD8+. Compared with those on postoperative d 1, serum IL-6 levels onpostoperative d 8 were significantly depressed in the FO group than in the reference group (-44.43 ± 30.53 vs -8.39 ± 69.08, P = 0.039). Simultaneously, the ratios of CD4+/CD8+ were significantly increased in the FO group (0.92 ± 0.62 vs 0.25 ± 1.22, P = 0.035). In addition, depression of serum TNF-α levels (-0.82 ± 2.71 vs 0.27 ± 1.67, P = 0.125) and elevation of CD3+ and CD4+ lymphocyte percentage (12.85 ± 11.61 vs 3.84 ± 19.62, P = 0.081, 17.80 ± 10.86 vs 9.66 ± 17.55, P = 0.084, respectively) were higher in the FO group than in the reference group. Patients in the FO group trended to need a shorter postoperative hospital stay (17.45 ± 4.80 d vs 19.62 ± 5.59 d, P = 0.19). No statistically significant difference was found when stratified to mortality and occurrence of infectious complications. CONCLUSION: Postoperative supplementation of omega-3 fatty acids may have a favorable effect on the outcomes in colorectal cancer patients undergoing radical resection by lowering the magnitude of inflammatory responses and modulating the immune response. | Bin Liang, Shan Wang, Ying-Jiang Ye, Xiao-Dong Yang, You-Li Wang, Jun Qu, Qi-Wei Xie, Mu-Jun Yin, Division of Surgical Oncology and Division of Gastroenterological Surgery, Peking University People’s Hospital, Beijing 100044, China Author contributions: Liang B and Wang S contributed equally to this work Liang B and Wang S designed the research Liang B, Ye YJ, Yang XD, Wang YL, Qu J, Xie QW, Yin MJ performed the research and collected the data Wang S and Ye YJ supervised the research Liang B and Ye YJ analyzed the data Liang B wrote the paper and revised the manuscript. | 2008 | World Journal of Gastroenterology2008，14，15： | 31 |
| 2 | Functional Variant in microRNA-196a2 Contributes to the Susceptibility of Congenital Heart Disease in a Chinese Population显示文摘 | XU , J. Hu, Z.B. Xu, Z.F. Gu, H.Y Yi, L. Cao, H. L. Chen, J. P. Tian, T. Liang, J. Lin, Y. Qiu, W. S. Ma, H.X. Shen, H. B Chen, Y. J. | 2009 | 南京医科大学学报(自然科学版)2009，29，11： | 20 |
| 3 | Monitoring the impact of climate change and human activities on grassland vegetation dynamics in the northeastern Qinghai-Tibet Plateau of China during 2000–2015显示文摘Climate change and human activities can influence vegetation net primary productivity(NPP), a key component of natural ecosystems. The Qinghai-Tibet Plateau of China, in spite of its significant natural and cultural values, is one of the most susceptible regions to climate change and human disturbances in the world. To assess the impact of climate change and human activities on vegetation dynamics in the grassland ecosystems of the northeastern Qinghai-Tibet Plateau, we applied a time-series trend analysis to normalized difference vegetation index(NDVI) datasets from 2000 to 2015 and compared these spatiotemporal variations with trends in climatic variables over the same time period. The constrained ordination approach(redundancy analysis) was used to determine which climatic variables or human-related factors mostly influenced the variation of NDVI. Furthermore, in order to determine whether current conservation measures and programs are effective in ecological protection and reconstruction, we divided the northeastern Qinghai-Tibet Plateau into two parts: the Three-River Headwater conservation area(TRH zone) in the south and the non-conservation area(NTRH zone) in the north. The results indicated an overall(73.32%) increasing trend of vegetation NPP in grasslands throughout the study area. During the period 2000–2015, NDVI in the TRH and NTRH zones increased at the rates of 0.0015/a and 0.0020/a, respectively. Specifically, precipitation accounted for 9.2% of the total variation in NDVI, while temperature accounted for 13.4%. In addition, variation in vegetation NPP of grasslands responded not only to long-and short-term changes in climate, as conceptualized in non-equilibrium theory, but also to the impact of human activities and their associated perturbations. The redundancy analysis successfully separated the relative contributions of climate change and human activities, of which village population and agricultural gross domestic product were the two most important contributors to the NDVI changes, explaining 17.8% and 17.1% of the total variation of NDVI(with the total contribution >30.0%), respectively. The total contribution percentages of climate change and human activities to the NDVI variation were 27.5% and 34.9%, respectively, in the northeastern Qinghai-Tibet Plateau. Finally, our study shows that the grassland restoration in the study area was enhanced by protection measures and programs in the TRH zone, which explained 7.6% of the total variation in NDVI. | XIONG Qinli XIAO Yang Marwa Waseem A HALMY Mohammed A DAKHIL LIANG Pinghan LIU Chenggang ZHANG Lin Bikram PANDEY PAN Kaiwen Sameh B EL KAFRAWAY CHEN Jun | 2019 | Journal of Arid Land2019，11，5： | 10 |
| 4 | 影响牙源性感染引起的下行性坏死性纵隔炎预后的危险因素显示文摘目的:下行性坏死性纵隔炎(DNM)是头颈部感染的严重并发症,由于缺乏对DNM的理解,死亡率过高。我们评估了牙源性DNM的临床特征、诊断、治疗和结果,并评估了影响DNM预后的危险因素,为临床实践提供了最新的概览。材料与方法:回顾性队列研究收集了2013年1月-2016年12月间因牙源性感染导致的DNM患者,分为存活组和死亡组。 | Qu L Liang X Jiang B 赵泽亮 | 2018 | 中国口腔颌面外科杂志2018，16，4： | 8 |
| 5 | Strategies for increasing the capture, storage, and utilization of precipitation in semiarid regions显示文摘Crop production in semiarid regions is always challenging because of the high variability of amount and distribution of precipitation.These regions become more important each year, however, because the rapidly increasing and more prosperous world population seeks greater consumption of animal products(meat, milk and eggs) that requires additional grain to that consumed directly.The dry areas of the developing world where approximately 40% of the world population lives comprise about 40% of the earth's land area.Crop production, particularly cereal grains, must increase in these areas to meet these growing demands.Grain yield of cereal crops is a function of the amount of water used for evapotranspiration(ET), the portion of ET used for transpiration(T), the units of water as T to produce 1 unit of biomass, and the harvest index(HI).The most important factor is the amount of evapotranspiration not only because it is closely proportional to grain yield, but because it tends to also make the other factors more favorable.Therefore, even small increases in ET can be significant.Strategies for manipulating soil and plant conditions for increasing ET, and how additional ET affects the other factors, are discussed for water deficient areas.The use of crop residues as mulch is highly beneficial but often insufficient in dryland regions or is required for animal feed and fuel.Plastic mulch, mainly restricted to China, has significantly increased grain yields in dryland areas by decreasing evaporation from the soil surface. | B A Stewart LIANG Wei-li | 2015 | Journal of Integrative Agriculture2015，14，8： | 8 |
| 6 | Progression of diabetic retinopathy: the Beijing Eye Study显示文摘当在工作人口 worldwide.This 学习的视觉缺陷和盲目的一个领先的原因试图估计频率并且在北京眼睛学习是的基于人口的 setting.Methods 在题目把医生的前进的因素与已知的糖尿病联系了,背景糖尿病的 retinopathy (医生)出现了基于的学习在更大的北京执行了的一张人口在在场的 2001 和 2006 .The ,调查在 2001 与已知的糖尿病 mellitus 包括了所有题目,参予了后续 e ( 30 ) 51 使遭到在 2001 显示出医生的症状并且是在 2006,36 的 re-examined ( 21.2 )使遭到(与在基线在场的医生一起的 18 个题目,与在 2006 的最新诊断的医生一起的 18 个题目)在 follow-up.Progression 期间显示出医生的前进医生与农村区域被联系(机会比率(或): 5.43 , P0.001 )并且自我报导的动脉的高血压( OR:3.85 , P0.023 ) .In 非进步的亚群,医生的存在与教育的不同层次被联系(中学,中学,学院或更高, OR:0. | TU Ying XU Liang WEI Wen-bin WANG Shuang WANG Ya-xing Jost B Jonas | 2011 | Chinese Medical Journal2011，，22： | 7 |
| 7 | Hepatocellular carcinoma and non-alcoholic steatohepatitis:The state of play显示文摘Hepatocellular carcinoma(HCC) is now the fifth cancer of greatest frequency and the second leading cause of cancer related deaths worldwide. Chief amongst the risks of HCC are hepatitis B and C infection, aflatoxin B1 ingestion, alcoholism and obesity. The latter can promote non-alcoholic fatty liver disease(NAFLD), that can lead to the inflammatory form non-alcoholic steatohepatitis(NASH), and can in turn promote HCC. The mechanisms by which NASH promotes HCC are only beginning to be characterized. Here in this review, we give a summary of the recent findings that describe and associate NAFLD and NASH with the subsequent HCC progression. We will focus our discussion on clinical and genomic associations that describe new risks for NAFLD and NASH promoted HCC. In addition, we will consider novel murine models that clarify some of the mechanisms that drive NASH HCC formation. | Bérénice Charrez Liang Qiao Lionel Hebbard | 2016 | World Journal of Gastroenterology2016，22，8： | 6 |
| 8 | Advances in alcoholic liver disease:An update on alcoholic hepatitis显示文摘Alcoholic hepatitis is a pro-inflammatory chronic liver disease that is associated with high short-term morbidity and mortality(25%-35% in one month) in the setting of chronic alcohol use. Histopathology is notable for micro- and macrovesicular steatosis, acute inflammation with neutrophil infiltration, hepatocellular necrosis, perivenular and perisinusoidal fibrosis, and Mallory hyaline bodies found in ballooned hepatocytes. Other findings include the characteristic eosinophilic fibrillar material(Mallory's hyaline bodies) found in ballooned hepatocytes. The presence of focal intense lobular infiltration of neutrophils is what typically distinguishes alcoholic hepatitis from other forms of hepatitis, in which the inflammatory infiltrate is primarily composed of mononuclear cells. Management consists of a multidisciplinary approach including alcohol cessation, fluid and electrolyte correction, treatment of alcohol withdrawal, and pharmacological therapy based on the severity of the disease. Pharmacological treatment for severe alcoholic hepatitis, as defined by Maddrey's discriminant factor ≥ 32, consists of either prednisolone or pentoxifylline for a period of four weeks. The body of evidence for corticosteroids has been greater than pentoxifylline, although there are higher risks of complications. Recently head-to-head trials between corticosteroids and pentoxifylline have been performed, which again suggests that corticosteroids should strongly be considered over pentoxifylline. | Randy Liang Andy Liu Ryan B Perumpail Robert J Wong Aijaz Ahmed | 2015 | World Journal of Gastroenterology2015，21，42： | 5 |
| 9 | Retrograde embolization technique of the right gastric artery during the implantation of port-catheter system for hepatic arterial infusion chemotherapy显示文摘Objective:This study aimed to introduce and evaluate a new embolization technique for the right gastric artery(RGA) during percutaneous implantation of a port-catheter system for hepatic arterial infusion chemotherapy(HAIC).Methods:From January 2013 to January 2017,159 patients with unresectable advanced liver cancer underwent percutaneous implantation of a port-catheter system.In 86 of these patients(56 men;aged 28-88 years;mean:60.6±12.0 years),in whom the RGA was obvious on arteriography,embolization of RGA was attempted using microcoils to protect the gastric mucosa during HAIC.In the first phase(first three years),antegrade embolization of the RGA using a 2.7 Fr microcatheter was performed in 55 patients.In the second phase(next two years),embolization of the RGA was attempted by combining antegrade embolization and retrograde embolization through the left gastric artery(LGA) in 31 patients.The success rates and the incidence of acute gastroduodenal mucosal toxicity(AGMT) in these two groups were compared.Results:The total success rate of the RGA embolization was 70.9%.The success rate was 83.9% in 31 patients who underwent combined antegrade and retrograde embolization,which was significantly higher than that of antegrade embolization alone(63.6%) performed in 55 patients(p=0.047).No complications related to embolization of RGA were documented.The incidence of AGMT was 29.1%(16/55) in patients in the first phase,which was significantly higher than that in the patients in the second phase(9.7%,3/31)(p=0.037).Conclusion: A combination of retrograde embolization via LGA could increase the success rates of RGA embolization and reduce the incidence of AGMT after HAIC. | Jungang Hu Guang Cao b Liang Xu Kanglian Zheng Xu Zhu Renjie Yang Xiao Wang Xiaodong Wang | 2021 | Journal of Interventional Medicine2021，4，1： | 3 |
| 10 | Introduction and constitutive expression of rice chitinase gene in bread wheat using biolistic bombardment and the bar gene as a selectable maker显示文摘 | Chen W P Gu X Liang G H Muthukrishnan S Chen P D Liu D J Giu B S | 1998 | Theor Appl Genet1998，97，12： | 2 |
| 11 | A low ripple power supply for high-current magnet load显示文摘 | Liang Rong Dewan S B | 1994 | IEEE Transactions on Industrial Applicatons1994，30，4： | 2 |
| 12 | A recombinant human angiostatin protein inhibits experimental primary and metastatic cancer 显示文摘 | Sim B K L O'Reilly M S Liang H | 1997 | Cancer Research1997，57，： | 2 |
| 13 | Influence of Eutrophication on the Distribution of Total Mercury and Methylmercury in Hydroelectric Reservoirs显示文摘 | Meng Bo Feng X B Chen C X Qiu G L Sommar J Guo Y N Liang P Wan Q | 2010 | EN2010，，5： | 2 |
| 14 | Synergy effects of Asperosaponin Ⅵ and bioactive factor BMP-2 on osteogenesis and anti-osteoclastogenesis显示文摘Osteoporosis is a reduction in skeletal mass due to the decrease of osteogenic ability and the activation of the osteoclastic function.Inhibiting bone resorption and accelerating the new bone formation is a promising strategy to repair the bone defect of osteoporosis.In this study,we first systematically investigated the roles of Chinese medicine Asperosaponin Ⅵ(ASP Ⅵ)on osteogenic mineralization of BMSCs and osteoclastogenesis of BMMs,and then explored the synergistic effect of ASP Ⅵ and BS(BMP-2 immobilized in 2-N,6-O-sulfated chitosan)on bone formation.The result showed that ASP Ⅵ with the concentration lower than 10^(-4) M contributed to the expression of osteogenic gene and inhibited osteoclastic genes RANKL of BMSCs.Simultaneously,ASP Ⅵ significantly reduced the differentiation of mononuclear osteoclasts in the process of osteoclast formation induced by M-CSF and RANKL.Furthermore,by stimulating the SMADs,TGF-β1,VEGFA,and OPG/RANKL signaling pathways,ASBS(ASP Ⅵ and BS)substantially enhanced osteogenesis,greatly promoted angiogenesis,and suppressed osteoclastogenesis.The findings provide a new perspective on osteoporosis care and prevention. | Fangping Chen Qing Liang Lijie Mao Yanrong Yin b Lixin Zhang Cuidi Li Changsheng Liu | 2022 | Bioactive Materials2022，7，4： | 2 |
| 15 | The Algorithm on Knowledge Reduction in Incomplete Information Systems显示文摘 | J Y Liang Z B Xu | 2002 | International Journal of Uncertainty Fuzziness and Knowledge-based Systems2002，10，1： | 2 |
| 16 | Simulation and fault detection of three-phase induction motors显示文摘 | LIANG B PAYNE B S BALL A D | 2001 | Mathematics and Computers in Simulation2001，61，： | 2 |
| 17 | Dynamical friction behavior in a forced oscillator with a compliant contact 显示文摘 | Liang J W Feeny B F | 1998 | ASME Journal of Applied Mechanics1998，65，3： | 1 |
| 18 | Observation of the transition from a Townsend discharge to a glow discharge in helium at atmospheric pressure显示文摘 | Luo H Y Liang Z Lv B | 2007 | Applied Physics Letters2007，91，22： | 1 |
| 19 | Characterization of a stimulatory adenosine A2a receptor in adult rat ventricular myocyte显示文摘 | Xu H Stein B Liang B | 1996 | Am J Physiol1996，270，52： | 1 |
| 20 | Histological and mechanical investigation of the bone-bonding ability of anodically oxidized titanium in rabblts显示文摘 | Liang B Fujibayashi S Neo M | 2003 | Biomaterials2003，24，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员