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| 1 | Titanium dioxide induced inflammation in the small intestine显示文摘AIM:To investigate the effects of titanium dioxide (TiO2) nanoparticles (NPTiO 2 ) and microparticles (MPTiO 2 ) on the inflammatory response in the small intestine of mice. METHODS: Bl 57/6 male mice received distilled water suspensions containing TiO 2 (100 mg/kg body weight) as NPTiO 2 (66 nm), or MPTiO 2 (260 nm) by gavage for 10 d, once a day; the control group received only distilled water. At the end of the treatment the duodenum, jejunum and ileum were extracted for assessment of cytokines, inflammatory cells and titanium content. The cytokines interleukin (IL)-1b, IL-4, IL-6, IL-8, IL-10, IL-12, IL-13, IL-17, IL-23, tumor necrosis factor-α (TNF-α), intracellular interferon-γ (IFN-γ) and transforming growth factor-β (TGF-β) were evaluated by enzyme-linked immunosorbent assay in segments of jejunum and ileum (mucosa and underlying muscular tissue). CD4 + and CD8 + T cells, natural killer cells, and dendritic cells were evaluated in duodenum, jejunum and ileum samples fixed in 10% formalin by immuno-histochemistry. The titanium content was determined by inductively coupled plasma atomic emission spectrometry. RESULTS: We found increased levels of T CD4 + cells (cells/mm 2 ) in duodenum:NP 1240 ± 139.4, MP 1070 ± 154.7 vs 458 ± 50.39 (P < 0.01); jejunum:NP 908.4 ± 130.3, MP 813.8 ± 103.8 vs 526.6 ± 61.43 (P < 0.05); and ileum:NP 818.60 ± 123.0, MP 640.1 ± 32.75 vs 466.9 ± 22.4 (P < 0.05). In comparison to the control group, the groups receiving TiO 2 showed a statistically significant increase in the levels of the inflammatory cytokines IL-12, IL-4, IL-23, TNF-α, IFN-γ and TGF-β. The cytokine production was more pronounced in the ileum (mean ± SE):IL-12: NP 33.98 ± 11.76, MP 74.11 ± 25.65 vs 19.06 ± 3.92 (P < 0.05); IL-4: NP 17.36 ± 9.96, MP 22.94 ± 7.47 vs 2.19 ± 0.65 (P < 0.05); IL-23: NP 157.20 ± 75.80, MP 134.50 ± 38.31 vs 22.34 ± 5.81 (P < 0.05); TNFα: NP 3.71 ± 1.33, MP 5.44 ± 1.67 vs 0.99± 019 (P < 0.05); IFNγ: NP 15.85 ± 9.99, MP 34.08 ± 11.44 vs 2.81 ± 0.69 (P < 0.05); and TGF-β: NP 780.70 ± 318.50, MP 1409.00 ± 502.20 vs 205.50 ± 63.93 (P < 0.05). CONCLUSION:Our findings indicate that TiO2 particles induce a Th1-mediated inflammatory response in the small bowel in mice. | Carolina Maciel Nogueira Walter Mendes de Azevedo Maria Lucia Zaidan Dagli Sérgio Hiroshi Toma AndréZonetti de Arruda Leite Maria Laura Lordello Iêda Nishitokukado Carmen Lúcia Ortiz-Agostinho Maria IrmaSeixas Duarte Marcelo Alves Ferreira Aytan Miranda Sipahi | 2012 | World Journal of Gastroenterology2012，18，34： | 8 |
| 2 | An unusual case of incidental rupture of liver hemangioma during labor显示文摘Cavernous hemangiomas are the most common benign tumors of the liver and are found in about 2% of autopsy patients. 1,2 The vast majority of these tumors are small and asymptomatic; however, there have been a few reported cases in which these lesions led to spontaneous fatal hemorrhage. 1,2 Although liver hemangiomas occur in both sexes, most studies point to a female predominance; one study reported a ratio of female predominance of 4. 5: 1.3 It has been suggested that estrogen may be associated with the growth of liver hemangiomas, but the incidence of these lesions in pregnancy and the effect on them of the increased estrogen levels during pregnancy are unknown. 2 Symptomatic liver hemangiomas have been treated by steroids, radiation therapy, surgical resection and recently embolization, but surgeons may sometimes be confronted with intraabdominal hemorrhage originating from rupture of asymptomatic liver hemangiomas. This case describes an incidental intraabdominal hemorrhage originating from a liver hemangioma in a 36 weeks twin pregnancy being delivered emergently by Cesarean section due to fetal distress. | TayfunGüng(o|¨)r Hakan Aytan (O|¨)merLütfiTapisiz Sema Zergeroglu | 2004 | Chinese Medical Journal2004，17，2： | 2 |
| 3 | Relationship between maternal thyroid hormones and the biochemical markers of the first trimester aneuploidy screening显示文摘 | Hakan Aytan Ahmet C. Caliskan Fazl? Demirturk Semsettin Sahin Filiz Erdogan Zehra Kuzu | 2013 | Archives of Gynecology and Obstetrics2013，，6： | 1 |
| 4 | Office hysteroscopic evaluation of endometrium : can we hit the target 显示文摘 | Arslan S Aytan H Gunyeli I | 2005 | Arch Gynecol Obstet2005，271，3： | 1 |
| 5 | The effect of tocopherylphos- phates on atherosclerosis progression in rabbits fed with a higheholesterol diet显示文摘 | Negis Y Aytan N Ozer N | 2006 | Arch Physiol Biochem2006，，450： | 1 |
| 6 | Molecular mechanisms of cholesterol or homocysteine effect in the development of atherosclervsis:role of vitamin E显示文摘 | Kartal ON Negis Y Aytan N | 2003 | Biofactors2003，19，122： | 1 |
| 7 | Does hysterectomy af- fect ovarian function? Histopathologic evaluation and serum FSH, inhibin A, and inhibin B levels in an experimental rat model显示文摘 | Tapisiz O L Gungor T Aytan H | 2008 | Euro J Obstet Gynecol Reprod Biol2008，140，1： | 1 |
| 8 | Doppler study of myometrium in invasive gestational trophoblastic disease显示文摘 | Oguz S Sargin A Aytan H | 2004 | Int J Gynecol Cancer2004，14，5： | 1 |
| 9 | office hyslcroscopic evaluation of mdometrium :can we hit the target 显示文摘 | Arslan S Aytan H Gunyeli l | 2005 | Arch Gynecol Obstet2005，271，3： | 1 |
| 10 | Effect of the immunomodulator leflunomide on the induction of endometriosis in an experimental rat model 显示文摘 | Aytan H Caglar P Uygur D | 2007 | Fertil Steril2007，87，3： | 1 |
| 11 | Vitamin E inhibits CD36 scavenger receptor expression in hypercholesterolemic rabbits 显示文摘 | Ozer NK Negis Y Aytan N | 2006 | Atherosclerosis2006，184，1： | 1 |
| 12 | Cervical partial hydatidiform molar pregnancy显示文摘 | Aytan H Caliskan A C Demirturk F | 2008 | Gynecol Obstet Invest2008，66，2： | 1 |
| 13 | Molecular mechanisms of cholesterol or homocysteine effect in the development of atherosclerosis: role of vitamin E 显示文摘 | Kartal Ozer N Negis Y Aytan N | 2003 | Biofactors2003，19，12： | 1 |
| 14 | Effect of the immunomodulator le- flunomide on the induction of endometriosis in an experimental rat model 显示文摘 | Aytan H Caglar P Uygur D | 2007 | Fertil Steril2007，87，3： | 1 |
| 15 | Molecular mechanisms of cholesterol or homocysteine effect in the development of atherosclerosis:Role of vitamin E显示文摘 | Kartal Ozer N NegisY Aytan N | 2003 | Biofactors2003，19，12： | 1 |
| 16 | The effect of tocopheryl phos- phates on atheroscleresis progression in rabbits fed with a high cholesterol diet 显示文摘 | Negis Y Aytan N Ozer N | 2006 | Arch Physiol Biochem2006，450，1： | 1 |
| 17 | Effects of ovarian drilling in middle Black Sea region Turkish women with polycystic ovary syndrome having normal and high body mass indices显示文摘 | Demirturk F Caliskan AC Aytan H | 2006 | J Obstet Gynaecol Res2006，32，5： | 1 |
| 18 | Doppler study of myo-metrium in invasive gestational trophoblastic disease 显示文摘 | Oguz S Sargin A Aytan H | 2004 | Int J Gynecol Cancer2004，14，5： | 1 |
| 19 | The effect of episiotomy on pelvic organ prolapse assessed by pelvic organ prolapse quantification system 显示文摘 | Aytan H Tok EC Ertunc D | 2014 | Eur J Obstet Gynecol Reprod Biol2014，173，： | 1 |
| 20 | The effect of episiotomy on pelvic organ prolapse assessed by pelvic organ prolapse quantification sys- tem显示文摘 | Aytan H iTok EC Ertunc D | 2013 | Eur J Gynecol Reprod Biol2013，，173： | 1 |
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