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| 1 | Leptin treatment ameliorates acute lung injury in rats with cerulein-induced acute pancreatitis显示文摘AIM:To determine the effect of exogenous leptin on acute lung injury (ALI) in cerulein-induced acute pancreatitis (AP). METHODS:Forty-eight rats were randomly divided into 3 groups. AP was induced by intraperitoneal (i.p.) injection of cerulein (50 μg/kg) four times,at 1 h intervals. The rats received a single i.p. injection of 10 μg/kg leptin (leptin group) or 2 mL saline (AP group) after cerulein injections. In the sham group,animals were given a single i.p. injection of 2 mL saline. Experimental samples were collected for biochemical and histological evaluations at 24 h and 48 h after the induction of AP or saline administration. Blood samples were obtained for the determination of amylase,lipase,tumor necrosis factor (TNF)-a,interleukin (IL)-1β,macrophage inflammatory peptide (MIP)-2 and soluble intercellular adhesion molecule (sICAM)-1 levels,while pancreatic and lung tissues were removed for myeloperoxidase (MPO) activity,nitric oxide (NOx) level,CD40 expression and histological evaluation. RESULTS:Cerulein injection caused severe AP,confirmed by an increase in serum amylase and lipase levels,histopathological findings of severe AP,and pancreatic MPO activity,compared to the values obtained in the sham group. In the leptin group,serum levels of MIP-2,sICMA-1,TNF-a,and IL-1b,pancreatic MPO activity,CD40 expression in pancreas and lung tissues,and NOx level in the lung tissue were lower compared to those in the AP group. Histologically,pancreatic and lungdamage was less severe following leptin administration. CONCLUSION:Exogenous leptin attenuates inflammatory changes,and reduces pro-inflammatory cytokines,nitric oxide levels,and CD40 expression in ceruleininduced AP and may be protective in AP associated ALI. | Fatma Ayca Gultekin Mustafa Kerem Ertan Tatlicioglu Aysel Aricioglu Cigdem Unsal Neslihan Bukan | 2007 | World Journal of Gastroenterology2007，13，21： | 23 |
| 2 | Comparison of multichannel intraluminal impedance-pH monitoring and reflux scintigraphy in pediatric patients with suspected gastroesophageal reflux显示文摘AIM To evaluate the agreement of multichannel intraluminal impedance-p H monitoring(MII-p HM) and gastroesophageal reflux scintigraphy(GES) for the diagnosis of gastroesophageal reflux disease. METHODS Seventy-five consecutive patients with suspectedgastroesophageal reflux disease(GERD) underwent 24-h combined MII-p HM recording and one hour radionuclide scintigraphy during the course of the MIIpH M study. Catheters with 6 impedance channels and 1 p H sensor were placed transnasally. Impedance and p H data analysis were performed automatically and manually. For impedance monitoring, reflux was defined as a retrograde 50% drop in impedance, starting distally and propagating retrogradely to at least the next two more proximal measuring channels. Reflux index(RI, percentage of the entire record that esophageal p H is < 4.0) greater than 4.2% for p HM and number of refluxes more than 50 for 24 h for MII were accepted as positive test results. At scintigraphy, 240 frames of 15 seconds duration were acquired in the supine position. Gastroesophageal reflux was defined as at least one reflux episode in the esophagus. After scintigraphic evaluation, impedance-pH recordings and scintigraphic images were evaluated together and agreement between tests were evaluated with Cohen's kappa.RESULTS Sufficient data was obtained from 60(80%) patients(34 male, 56.7%) with a mean age of 8.7 ± 3.7 years(range: 2.5-17.3 years; median: 8.5 years). Chronic cough, nausea, regurgitation and vomiting were the most frequent symptoms. The mean time for recording of MII-pH M was 22.8 ± 2.4 h(range: 16-30 h; median: 22.7 h). At least one test was positive in 57(95%) patients. According to diagnostic criteria, GERD was diagnosed in 34(57.7%), 44(73.3%), 47(78.3%) and 51(85%) patients by means of p HM, MII, GES and MII-p HM, respectively. The observed percentage agreements/κ values for GES and p HM, GES and MII, GES and MII-p HM, and MII and p HM are 48.3%/-0.118; 61.7%/-0.042; 73.3%/0.116 and 60%/0.147, respectively. There was no or slight agreement between GES and p HM alone, MII alone or MII-p HM. p H monitoring alone missed 17 patients compared to combined MII-p HM. The addition of MII to pH monitoring increased the diagnosis rate by 50%.CONCLUSION No or slight agreement was found among p H monitoring, MII monitoring, MII-pH monitoring and GES for the diagnosis of gastroesophageal reflux disease. | Nuray Uslu Kizilkan Murat Fani Bozkurt Inci Nur Saltik Temizel Hülya Demir Aysel Yüce Biray Caner Hasan Ozen | 2016 | World Journal of Gastroenterology2016，22，43： | 2 |
| 3 | Differential diagnosis in ulcerative colitis in an adolescent: Chronic granulomatous disease needs extra attention显示文摘Chronic granulomatous disease(CGD) is a primary immune deficiency that is commonly diagnosed under the age of 5 years(95%) and is rarely seen in adulthood. CGD may manifest as inflammatory bowel disease(IBD) in childhood. Without proper diagnosis, these patients may be monitored for years as IBD; some may even be regarded as steroid-resistant ulcerative colitis(UC) and end up having a colectomy. In this case report, we described a patient who had been followedup for years as UC and subsequently underwent colectomy, but was finally diagnosed in adulthood as primary immune deficiency. | Daniel Kotlarz Odul Egritas Gurkan Zehra Sule Haskologlu Ozgur Ekinci Aysel Aksu Unlusoy Neslihan Gürcan Kaya Jacek Puchalka Cristoph Klein Buket Dalgic | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，2： | 2 |
| 4 | Circulating CD4+CD25+ Regulatory T Cells in the Pathobiology of Ulcerative Colitis and Concurrent Primary Sclerosing Cholangitis显示文摘 | Murat Kekilli Bilge Tunc Yavuz Beyazit Mevlut Kurt Ibrahim Koral Onal Aysel Ulker Ibrahim Celalettin Haznedaroglu | 2013 | Digestive Diseases and Sciences2013，，5： | 1 |
| 5 | Low incidence of colorectal dysplasia and cancer among patients with ulcerative colitis: A Turkish referral centre study显示文摘 | Murat Kekilli Ulku Dagli Ismail Hakki Kalkan Bilge Tunc Selcuk Disibeyaz Aysel Ulker Burhan Sahin | 2010 | Scandinavian Journal of Gastroenterology2010，，4： | 1 |
| 6 | Low incidence of colorectal dysplasia and cancer among patients with ulcerative colitis: A Turkish referral centre study显示文摘 | Murat Kekilli Ulku Dagli Ismail Hakki Kalkan Bilge Tunc Selcuk Disibeyaz Aysel Ulker Burhan Sahin | 2010 | Scandinavian Journal of Gastroenterology2010，，4： | 1 |
| 7 | Small arterial elasticity predicts the extent of coronary artery disease: Relationship with serum uric acid显示文摘 | Murat Fazl?o?lu Tunay ?entürk Ethem Kumbay Aysel Ayd?n Kaderli Yusuf Yilmaz Bülent ?zdemir ?brahim Baran Ali Ayd?nlar | 2008 | Atherosclerosis2008，，1： | 1 |
| 8 | Effects of hemolysis interference on routine biochemistry parameters显示文摘 | Mehmet Koseoglu Aysel Hur Aysenur Atay Serap Cuhadar | 2011 | Biochemia Medica2011，，1： | 1 |
| 9 | Over-time changes in PTSD and depression among children surviving the 1999 Istanbul earthquake显示文摘 | Aysel Eksi MD Kathryn L. Braun DrPH | 2009 | European Child & Adolescent Psychiatry2009，，6： | 1 |
| 10 | Blood pressure and ejection fraction changes due to ultrafiltration in hemodialysis 显示文摘 | Kursat S Aysel S Alici T | 2006 | J Nephrol2006，19，1： | 1 |
| 11 | Abducens nerve palsy and optic neuritis as initial manifestation in brucellosis显示文摘 | Basak Karakurum Goksel Deniz Yerdelen Mehmet Karatas Aysel Pelit Y.Ziya Demiroglu O. Kizilkilic Meliha Tan1 Okan Toygar | 2006 | Scandinavian Journal of Infectious Diseases2006，，： | 1 |
| 12 | Experimental acute myocardial infarction in rats: HIF-1α, caspase-3, erythropoietin and erythropoietin receptor expression and the cardioprotective effects of two different erythropoietin doses显示文摘 | Aysel Guven Bagla Ertugrul Ercan Halil Fatih Asgun Meltem Ickin Feriha Ercan Ozlem Yavuz Suat Bagla Askin Kaplan | 2013 | Acta Histochemica2013，，： | 1 |
| 13 | The effects of sufentanil added to low-dose hyperbaric bupivacaine in unilateral spinal anaesthesia for outpatients undergoing knee arthroscopy显示文摘 | Sertz N Aysel Uyar M | 2014 | Agri2014，26，4： | 1 |
| 14 | A new record of the freshwater jellyfish Craspedacusta sowerbii Lankester,1880(Hydrozoa)in Southeastern Anatolia(Turkey)显示文摘We report the first record of the invasive freshwater jellyfish Craspedacusta sowerbii Lankester in Kralk1z1 Dam Lake,Southeastern Anatolia,Turkey.The medusa was found only in August,2008 when average surface water temperatures were 26.9℃. | Aysel BEKLEYEN Memet VAROL Bulent GOKOT | 2011 | Chinese Journal of Oceanology and Limnology2011，29，2： | 1 |
| 15 | Partial external biliary diversion for the treatment of intractable pruritus in children with progressive familial intrahepatic cholestasis: Report of two cases显示文摘 | Saniye Ekinci ?brahim Karnak Figen Gürakan Aysel Yüce Mehmet Emin ?enocak F. Cahit Tanyel Nebil Büyükpamuk?u | 2008 | Surgery Today2008，，8： | 1 |
| 16 | Investiga-tion of combustion kinetics of treated and untreatedwaste wood samples with thermogravimetric analysis显示文摘 | Yorulmaz Sema Yurdakul Atimtay Aysel T | 2009 | Fuel Processing Technology2009，90，78： | 1 |
| 17 | Preoperative staging of colorecta显示文摘 | Derya Tezcan Aysel Ttirkvatan Meh- met Akif Ttirkoglu et at | 2013 | Clini- cal Imaging2013，37，6： | 1 |
| 18 | Comparison of the Effectiveness of Topiramate and Sodium Valproate in Pediatric Migraine 显示文摘 | Ayean Unalp Nedret Uran Aysel Oztuk | 2008 | Journal of Child Neurology2008，23，12： | 1 |
| 19 | Seasonal changes of total carbohydrate contents in three varieties of apple (Malus sylvestris Miller) stem cut- tings 显示文摘 | Aysel Sivaei | 2006 | Scientia Horticulturae2006，109，3： | 1 |
| 20 | The effect of age on conventional parameters of event-related potentials显示文摘 | Aysel agar Piraye Yargicoglu | 1994 | Journal of Islamic Academy of Sciences1994，7，3： | 1 |
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