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| 1 | Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice显示文摘Stress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal stress(PS) and disrupted glucocorticoid signaling on bone mass and strength is not understood. In contrast, the detrimental effect of lead(Pb) on skeletal health is well documented. As stress and Pb act on common biological targets via glucocorticoid signaling pathways and co-occur in the environment, this study first sought to assess the combined effect of stress and Pb on bone quality in association with alterations in glucocorticoid signaling. Bone parameters were evaluated using microCT, histomorphometry, and strength determination in 8-month-old male mouse offspring subjected to PS on gestational days 16 and 17, lifetime Pb exposure(100 p.p.m. Pb in drinking water), or to both. Pb reduced trabecular bone mass and, when combined with PS, Pb unmasked an exaggerated decrement in bone mass and tensile strength. Next, to characterize a mechanism of glucocorticoid effect on bone, prednisolone was implanted subcutaneously(controlled-release pellet, 5 mg·kg^(-1) per day) in 5-month-old mice that decreased osteoblastic activity and increased sclerostin and leptin levels. Furthermore, the synthetic glucocorticoid dexamethasone alters the anabolic Wnt signaling pathway. The Wnt pathway inhibitor sclerostin has several glucocorticoid response elements, and dexamethasone administration to osteoblastic cells induces sclerostin expression. Dexamethasone treatment of isolated bone marrow cells decreased bone nodule formation, whereas removal of sclerostin protected against this decrement in mineralization.Collectively, these findings suggest that bone loss associated with steroid-induced osteoporosis is a consequence of sclerostin-mediated restriction of Wnt signaling, which may mechanistically facilitate glucocorticoid toxicity in bone. | Eric E Beier Tzong-Jen Sheu Emily A Resseguie Masahiko Takahata Hani A Awad Deborah A Cory-Slechta J Edward Puzas | 2017 | Bone Research2017，5，2： | 3 |
| 2 | Studies on inducing mutations in bougainvillea显示文摘 | Abd EI-Mageid y A Awad A E | 2009 | Zagazig Journal of Agricultural Research2009，，： | 1 |
| 3 | Echinococcosis (zoonotic hydatidosis) in street dogs in urban and rural areas,Dakahlia Governorate, Egypt显示文摘 | Elshazly A M Awad S E Abdel Tawab A H | 2007 | J Egypt Soc Parasitol2007，37，1： | 1 |
| 4 | Effect of light on flavonoid and chloragenic acid level in the skin of Jonagold apples 显示文摘 | Awad M A Wagenmakers P S Jager A D E | 2001 | Sci Hort2001，88，4： | 1 |
| 5 | Chaos and adaptive control in two preys, one predator system with nonlinear feedback 显示文摘 | Awad E G Alruzaiza A S | 2007 | Chaos Solitons and Fraetals (S0960-0779)2007，34，2： | 1 |
| 6 | Preliminary studies of a newly developed subunit vaccine for channel cat- fish virus disease 显示文摘 | AWAD M A NUSBAUM K E BRADY Y J | 1989 | Journal of Aquatic Animal Health1989，1，7： | 1 |
| 7 | Peroxisomal enzymes and 8-hydroxydeoxyguanosine in rat liver treated with perfluorooctanoic acid显示文摘 | Abdellatif A Al-Tonsy A H Awad M E | | 0，，01： | 1 |
| 8 | Influence of self-healing, mixing method and adding silica fume on mechanical properties of recycled aggregates concrete 显示文摘 | Elhakam A A Mohamed A E Awad E | 2012 | Construction and Building Materials2012，，： | 1 |
| 9 | Effect of addition of a probiotic microorganism to'broiler diets contaminated with deoxynivalenol on performance and histological alterations of in- testinal villi of broiler chickens显示文摘 | Awad W A Bohm J Razzazi-Fazeli E | 2006 | Poultry Science2006，85，6： | 1 |
| 10 | Applications of ultrasound in analysis, processing and quality control of food: A review显示文摘 | Awad T S Moharram H A Shahout O E | 2012 | Food Research Interational2012，48，2： | 1 |
| 11 | Applications of ultrasound in analysis,processing and quality control of food:A review显示文摘 | Awad T S Moharram H A Shaltout O E | 2012 | Food Research International2012，，48： | 1 |
| 12 | Acrylamide toxicity in isolated rat hepatocytes显示文摘 | M E Awad M S Abdel-Rahaman S A Hassan | 1998 | Toxicology in vitro1998，12，： | 1 |
| 13 | Effect of addition of a probiotic microorganism to broiler diets contaminated with deoxynivalenol on performance and histological alterations of intestinal villi of broiler chicken 显示文摘 | AWAD W A BOHM J RAZZAZI-FAZELI E | 2006 | Poultry Science2006，85，6： | 1 |
| 14 | Keratinase production by Bacillus pumilus GHD in solid-state fermentation using sugar cane bagasse :optimisation of culture conditions using a Box-Behnken experimental design显示文摘 | Awad G E A M A Esawyet | 2011 | Annals of Microbiology2011，61，3： | 1 |
| 15 | Insights on the host stress, fear and growth responses to the deoxynivalenol feed contaminant in broiler chickens显示文摘 | Ghareeb K Awad W A Sid-Ahmed O E | 2014 | PLoS ONE2014，9，1： | 1 |
| 16 | Blastoeystis hominis as a cause of hypoalbuminemia and anasarea显示文摘 | Nassir E Awad J Abel A B | 2004 | Eur J Clin Micro- biol Inefeet Dis2004，23，5： | 1 |
| 17 | Effects of feeding deoxynivalenol contaminated wheat on growth performance,organ weights and histological parameters of the intestine of broiler chickens显示文摘 | AWAD W A BOHM J RAZZAZI-FAZELI E | 2006 | Journal of Animal Physiology and Animal Nutrition2006，90，12： | 1 |
| 18 | Biology of vascular mal- formations of the brain 显示文摘 | Leblanc G G Golanov E Awad I A | 2009 | Stroke2009，40，12： | 1 |
| 19 | Polymer/layered silicate nanocomposites from thermally stable trialkylimidazolium-treated montmorillonite 显示文摘 | Gilman J W Awad W H Davis R D Shields J Harris Jr RH Davis C Morgan A B Sutto T E Callahan J Trulove P C DeLong H C | 2002 | Chem Mater2002，14，： | 1 |
| 20 | Insights on the host stress, fear and growth responses to the deoxynivalenol feed contaminant in broiler chickens 显示文摘 | Ghareeb K Awad W A Sid-Ahmed O E | 2014 | PLoS One2014，9，87： | 1 |
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