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| 1 | Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis显示文摘AIM To evaluate the effect of silymarin on the serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST) and gamma glutamyl transpeptidase(γGT) in patients with liver diseases. METHODS A systematic review with meta-analysis of ramdomized and controlled clinical trials was performed,evaluating the effects of sylimarin in patients with hepatic diseases,published by January 31,2016. Clinical trials were sought on the basis of The Cochrane Central Register of Controlled Trials in the Cochrane Library,Pub Med/Medline,Scopus,Web of Science,Lilacs and Clinical Trials. The trials with adult and elderly patients of both sexes,with Liver Diseases who took oral silymarin supplementation,as extract or isolated,as well as Silymarin combined with other nutrients,were included. The trials should provide information about the intervention,such as dosages and detailing of the product used,besides the mean and standard deviation of serum levels of ALT,AST and γGT of the baseline and at the end of the intervention.RESULTS An amount of 10904 publications were identified. From those,only 17 were included in the systematic review and 6 in the meta-analysis,according to the used selection criteria. In this meta-analysis,the results indicated a reduction of 0.26 IU/m L(95%CI:-0.46-0.07,P = 0.007) at the level of ALT and 0.53 IU/m L(95%CI:-0.74-0.32,P = 0.000) at the serum levels of AST after using the silymarin,both,statistically significant,but with no clinical relevance. There was no significant change in the γGT levels. Subgroup analyzes were also performed for the biochemical markers in relation to the type of intervention,whether silymarin isolated or associated with other nutrients and the time of intervention(whether ≥ 6 mo or < 6 mo). Significant differences were not found. The evaluated studies presented a high degree of heterogeneity and low methodological quality in the carried out analysis. CONCLUSION Silymarin minimally reduced,but without clinical relevance,the serum levels of ALT and AST. It is necessary to carry out studies with more appropriate methodological designs. | Camila Ribeiro de Avelar Emile Miranda Pereira Priscila Ribas de Farias Costa Rosangela Passos de Jesus Lucivalda Pereira Magalhaes de Oliveira | 2017 | World Journal of Gastroenterology2017，23，27： | 5 |
| 2 | A double-blind, comparative, placebo-controlled study of the efficacy and tolerability of 4% hydroquinone as a depigmenting agent in melasma显示文摘 | Ennes SBP Paschoalick RC De Avelar Alchorne MM | 2000 | J Dermatolog Treat2000，11，3： | 1 |
| 3 | Favorable changes in cardiac geometry and function following gastric bypass surgery:2-year follow-up in the Utah obesity study显示文摘 | Owan T Avelar E Morley K | 2011 | J Am Coil Cardiol2011，57，6： | 1 |
| 4 | Effect of two routes of adrninistration of dexamethasone on pain,edema,and trismus in impacted fuwer third molar surgery显示文摘 | Antunes AA Avelar RL Martins Neto EC | | 0，，04： | 1 |
| 5 | Functional per- formance and inflammatory cytokines after squat exercises and whole-body vibration in elderly individuals with knee osteoar- thritis显示文摘 | Simao AP Avelar NC Tossige-Gomes R | 2012 | Arch Phys Med Rehabil2012，93，10： | 1 |
| 6 | Whole-body vi- bration decreases the proliferative response of TCD4( + ) cells in eldeAy individuals with knee osteoarthritis显示文摘 | Tossige-Gomes R Avelar NC Simao AP | 2012 | Braz J Med Biol Res2012，45，12： | 1 |
| 7 | Analysis of the applicability of the time-driven activity-based costing in make-to-order companies 显示文摘 | DE SOUZA A A AVELAR E A BOINA T M | 2010 | Revista Universo Cont~bil2010，6，1： | 1 |
| 8 | Chagas disease :increased parasitemia during pregnancy detected by hemocul-ture显示文摘 | Siriano L R Luguetti A O Avelar J B | 2011 | Am J Trop Med Hyg2011，84，： | 1 |
| 9 | The effect of feeding wheat distillers dried grain with soluble on growth performance andnutrient digestibility in weaned pigs显示文摘 | Avelar E Jha R Beltranena E | 2010 | Animal Feed Science and Technology2010，160，1： | 1 |
| 10 | Use of zoledronie acid in the treatment of Gorham's disease显示文摘 | Avelar RL Martins VB Antunes AA | 2010 | Int J Pediatr O- torhinolaryngol2010，74，3： | 1 |
| 11 | Water-tight knee arth- rotomy closure:comparison of a novel single bidirectional barbed self-retaining running suture versus conventional in- terrupted sutures显示文摘 | Nett M Avelar R Sheehan M | 2011 | J Knee Surg2011，24，1： | 1 |
| 12 | Spermatogenesis and sperm transit through the epididymis in mammals with emphasis on pigs显示文摘 | Fran?a LR Avelar GF Almeida FFL | 2005 | Theriogenology2005，，8： | 1 |
| 13 | Reverse Pseudohyperkalemia in a Patient with Chronic Lymphocytic Leukemia显示文摘 | Avelar T | 2014 | Penn J2014，18，4： | 1 |
| 14 | Teleporting Entanglements of Cvity-field States 显示文摘 | PIRES G DE ALMEIDA N G AVELAR A T | 2004 | Phys RevA2004，70，2： | 1 |
| 15 | Risk factors for and children: a cross- sectional cohort study 显示文摘 | Kusahara DM Enz Cda C Avelar AF ventilator-associated pneumonia in infants | 2014 | Am J Crit Care2014，23，6： | 1 |
| 16 | A Note on Entanglement Swapping of Atomic States Through thePhotonicFaradayrotation显示文摘 | BASTOS W P CARDOSO W B AVELAR A T | 2011 | QuantInfProcess2011，10，： | 1 |
| 17 | Risk factors for ventilator-associated pneumonia in infants and children: a cross-sectional cohort study显示文摘 | Kusahara DM Enz CD Machado Avelar AF | 2014 | Am J Crit Care2014，23，6： | 1 |
| 18 | The use of piassava fibers (Attalea funifera) in the preparation of activated carbon显示文摘 | AVELAR F F BIANCHI M L GONCALVES M | 2010 | Bioresource Technol2010，101，12： | 1 |
| 19 | Clinical sigrificance of the laboratory determinations in preeclamptie patients显示文摘 | Peralta Pedrero M L Basavilvazo Rodriguez M A Cruz Avelar A | | 0，，03： | 1 |
| 20 | Natural killer cell subpopulations in putative resistant individuals and patients with active Mycobacterium tuberculosis infection显示文摘 | Barcelos W Sathler Avelar R Martins Filho OA | 2008 | Scand J Immunol2008，68，1： | 1 |
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