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| 1 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 2 | The protective efficacy of polyvalent pneumococcal polysaccharide vaccine 显示文摘 | Shapiro E D Berg A T Austrian R | 1991 | N Engl J Med1991，325，21： | 1 |
| 3 | Some observations on the pneumococcus and on the current status of pneumoccocal disease and prevention 显示文摘 | Austrian R | 1981 | Eev Infect Dis1981，，： | 1 |
| 4 | Prognostic Value of Lymphangiogenesis and Lymphovascular Invasion in Invasive Breast Cancer 显示文摘 | Austrian Breast and Colorectal Cancer Study Group | 2004 | Ann Surg2004，240，2： | 1 |
| 5 | The protective efficacyof polyvalent pneumococcal polysaccharide vaccine 显示文摘 | Shapiro ED Bei^ AT Austrian R | 1991 | N Engl JMed1991，325，21： | 1 |
| 6 | Considerations for fomu-lating the second-generation pneumo-coccal capsular polysaccha-ride vaccine with emphasis on the cross-reactive types within groups显示文摘 | Robbing JB Austrian R Lee CJ | 1983 | J Infect Dis1983，148，6： | 1 |
| 7 | Prognostic Value of Lymphangiogenesis and Lymphovascular Invasion in Invasive Breast Cancer显示文摘 | Austrian Breast and Colorectal Cancer Study Group | 2004 | Ann Surg2004，240，2： | 1 |
| 8 | The protective efficacy of polyvalent pneurmococcal polysaccharide vaccine显示文摘 | Shapiro ED Berg AT Austrian R | 1991 | N Engl J Med1991，325，21： | 1 |
| 9 | Some observation on the pneumococcus and on the current status of pneumococcal disease and its prevention显示文摘 | Austrian R | 1981 | Rev Infect Dis Suppl1981，3，： | 1 |
| 10 | Thrombolysis in patients with mild stroke: results from the Austrian Stroke Unit Registry 显示文摘 | Greisenegger S Seyfang L Kiechl S Austrian Stroke Unit Registry Collaborators | 2014 | Stroke2014，45，： | 1 |
| 11 | The protective efficacy of polyvalent pneumococcal polysaccharide vaccine 显示文摘 | SHAPIRO ED BERG AT AUSTRIAN R | 1991 | N Engl J Med1991，325，21： | 1 |
| 12 | Pneumococcal bacteremia with especial referance to bacteremic Pneumococcal pneumoniae显示文摘 | Gold J | 1964 | Ann Inter Med1964，60，5： | 1 |
| 13 | Confronting drug-resistant pneumococci显示文摘 | Austrian R | 1994 | Ann InternMed1994，21，10： | 1 |
| 14 | Some aspects of the pneumococcal carrier state显示文摘 | Austrian R | 1986 | JAntimicrob Chemother1986，18，： | 1 |
| 15 | Freight transportation demand:A survey of recent economic studies显示文摘 | Austrian A | 1989 | Transportation Journal1989，16，1： | 1 |
| 16 | The protective efficacy of polyvalent pneumococcal polysaccharide vaccine 显示文摘 | SHAPIRO ED BERG AT AUSTRIAN R | 1991 | N Eng J Med1991，325，21： | 1 |
| 17 | Some aspects of the pneumococcal carrier state 显示文摘 | Austrian R | 1986 | J Antimicrob Chemother1986，18，： | 1 |
| 18 | Freight Transportation De-mand:A Survey of Recent Econometric Studies 显示文摘 | Zlatoper T J Austrian A | 1989 | Transportation Journal1989，16，1： | 1 |
| 19 | The protectiveefficacy of polyvalent pneumococcal polysaccharide vac-cine显示文摘 | Shapiro ED Berg AT Austrian R | 1991 | N Engl J Med1991，325，21： | 1 |
| 20 | Pathogenesis of pneumococcal infection显示文摘 | Tuomanen EI Austrian R Masure HR | 1995 | N Engl J Med1995，332，19： | 1 |
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