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| 1 | In vitro properties of surface-modified solid lipid microspheres containing an antimalarial drug:halofantrine显示文摘Objective:To formulate and evaluate in vitro,surface-modified solid lipid microspheres containing hal of antrine using lipid matrix formed from goat fat and a phospholipid(P90H). Methods:The model drug,hal of antrine in an increasing concentration of 1%,2%,3%,4% and 5%w/w was incorporated into surface-modified solid lipid microspheres formulated by hot homogenization.Effect of drug concentration on the encapsulation efficiency was studied. The dispersion was evaluated using particle size,particle morphology,pH and encapsulation efficiency.The drug formulation with highest encapsulation efficiency was selected and used for the release studies and compared with the release from a commercial dosage form(Halfan~? 250 mg tablet,Claxo-Smithkline,Mayenne France) using simulated gastric fluid(SGF pH 1.2), simulated intestinal fluid(SIF pH 7.2) and phosphate buffer(pH 6.8) as biorelevant media. Results were analyzed statistically and the level of significance was taken to be P<0.05). Results:Discrete and spherical solid lipid microspheres were produced.The particle size of the dispersion was low(32.48-33.87μm) with minimal particle growth and high encapsulation efficiencies(86.8%-91.0%) after 3 months.The pH of the microspheres dispersion changed appreciably after 3 months.In vitro release result obtained revealed sustained and controlled drug release from the lipid microspheres compared with the tablet dosage form.Conclosions: Formulation of hal of antrine as solid lipid microspheres presents a better alternative to the conventional tablet formulation as the in vitro dissolution of the highly lipophilic hal of antrine was highly improved. | Anthony A Attama Collins N Igbonekwu | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，4： | 3 |
| 2 | Pharmacodynamics of piroxicam from self-emulsifying lipospheres formulated with homolipids extracted from Capra hircus 显示文摘 | Attama A A Mpamaugo V E | 2006 | Drug Deliv2006，13，2： | 1 |
| 3 | Fur- ther characterization of theobroma oil-beeswax admixtures as lipid matrices for improved drug delivery systems 显示文摘 | ATTAMA A A SCHICKE B C MULLER-GOYMANN C C | 2006 | Eur J Pharm Biopharm2006，64，3： | 1 |
| 4 | Effe-ct of beeswax modification on the lipid matrix and solid lipid nanoparticle crystallinity显示文摘 | ATTAMA A A CHRISTEL C MüLLER-GOYMANN | 2008 | Colloids Surfaces A2008，315，13： | 1 |
| 5 | Solid lipid nano- dispersions containing mixed lipid core and a polar heterolipid: characterization 显示文摘 | Attama A A Schicke B C Paepenmuller T | 2007 | Eur J Pharm Biopharm2007，67，1： | 1 |
| 6 | The use of solid self-emulsifying systems in the delivery of diclofenac 显示文摘 | Attama A A Nzekwe I T Nnamani P O | 2003 | Int J Pharm2003，262，12： | 1 |
| 7 | In vitro evaluation of drug re- lease from self-microe-mulsifying drug delivery systems using a biodegradable homolipid from Caprah - ireus显示文摘 | Attama A A Nkemnele M O | 2005 | lnt J Pharm2005，304，12： | 1 |
| 8 | Diclofenac sodium delivery to the eye:in vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct显示文摘 | ATTAMA A A REICHL S CHRISTEL C M | 2008 | Int J Pharm2008，355，12： | 1 |
| 9 | In vitro evaluation of drug release from self micro2emulsifying drug delivery systems using a biodegradable homolipid from Capra hircus显示文摘 | Attama A A Nkemnele M O | 2005 | Int J Pharm2005，304，42： | 1 |
| 10 | Investigation of surface- modified solid lipid nanoeontainers formulated with a heterolipid- templated homolipid显示文摘 | Attama AA Miiller-Goymann CC | 2007 | Int J Pharm2007，334，12： | 1 |
| 11 | In vitro evaluation of drug release from self micro-emulsifying drug delivery systems using a biodegradable homolipid from Capra hircus显示文摘 | Attama A A Nkemnele M O | 2005 | Int J Pharm2005，304，12： | 1 |
| 12 | Formulation and evaluation of stavuldine-loaded microsphere using ammonio methacrylate polymers显示文摘 | Ugwu A Attama A Momoh M | | 0，，10： | 1 |
| 13 | Novel multifunctional pharmaceutical excipients derived from microcrystalline cellulose–starch microparticulate composites prepared by compatibilized reactive polymer blending显示文摘 | Philip F. Builders Agbo M. Bonaventure Adelakun Tiwalade Larry C. Okpako Anthony A. Attama | 2010 | International Journal of Pharmaceutics2010，，1： | 1 |
| 14 | Diclofenac sodium delivery to the eye:In vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct显示文摘 | Attama A A Reich S Muller-Goymann C C | 2008 | Int J Pharm2008，355，12： | 1 |
| 15 | Solid lipid nanodispersions containing mixed lipid core and a polar heterolipld : Characterization 显示文摘 | Attama A A Sehieke B C Paepenmuler T | 2007 | Eur J Pharm Biopharm2007，67，1： | 1 |
| 16 | Intrinsic and functional properties of a gelling gum from Dioelea reflexa: a potential pharmaceutical exeipient 显示文摘 | Builders P F Mbah C C Attama A A | 2012 | Brit J Pharm Res2012，2，1： | 1 |
| 17 | In vitro evaluation of drug release from self micro-emulsifying drug delivery systems using a biodegradable homolipid from Capra hircus显示文摘 | ATTAMA A A NKEMNELE M O | 2005 | Int J Pharm2005，304，12： | 1 |
| 18 | Nanovesicular carriers as alternative drug delivery systems:ethosomes in focus显示文摘 | Mbah CC Builders PF Attama AA | 2014 | Expert Opin Drug Deliv2014，11，1： | 1 |
| 19 | The use of solid self-emulsifying systems in the delivery of diclofenac显示文摘 | Attama AA Nzekwe IT Nnamani PO | 2003 | Int J Pharm2003，262，12： | 1 |
| 20 | In vitro evaluation of drug release from self micro-emulsifying drug delivery systems using a biodegradable hornolipid from Capra hircus 显示文摘 | Attama AA Nkemnele MO | 2005 | Int JPharm2005，304，12： | 1 |
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