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25篇 您的检索式:作者名="Ashpole"
    题名 作者 年代 出处 被引量
1CaMKII in cerebral ischemia显示文摘神经原上的 Ischemic 侮辱触发引起 Ca 导致 neuronal 房间死亡(excitotoxicity ) 的 2+ 超载的过多的、病理学的 glutamate 版本。Ca 2+/calmodulin (凸轮) 依赖者蛋白质 kinase II (CaMKII ) 是位于 neuronal 粘性下面并且学习的生理的有刺激性的 glutamate 信号的一个主要调停人。Glutamate 刺激在 T286 触发 CaMKII 的 autophosphorylation,使 kinase 成为 “ 的一个过程; autonomous”(从 Ca 2+ 刺激的部分活跃的独立人士) 并且那为 synaptic 的形式被要求粘性。最近的研究为侮辱以后的 neuroprotection 作为潜在的药目标也建议了自治 CaMKII 活动,在在 neuronal 文化的 glutamate 侮辱以后并且在在 vivo 的焦点的服的局部缺血以后。然而, CaMKII 和凸轮 kinase 家庭的另外的成员在 neuronal 死亡和幸存的规定被含有。这里,我们在 excitotoxicity 和服的局部缺血讨论过去的调查结果和凸轮 kinase 功能的可能的机制,与 CaMKII 和它的规定的一个焦点。Steven J COULTRAP Rebekah S VEST Nicole M ASHPOLE Andy HUDMON K Ulrich BAYEF 2011Acta Pharmacologica Sinica2011,32,7:6
2Remifentanil sedation for awake fibreoptic intubation with limited application of local anaesthetic in patients for elective head and neck surgery显示文摘Mingo OH Ashpole KJ Irving CJ 2008Anaezthesia2008,63,10:1
3Maternal cardiac output changes after crystalloid or colloid coload following spinal anesthesia for elective cesarean delivery:a randomized controlled trial显示文摘McDonald S Fernando R Ashpole K 0,,04:1
4Calcium/calmodulindependent protein kinase II(Ca MKII)inhibition induces neurotoxicity via dysregulation of glutamate/calcium signaling and hyperexcitability显示文摘Ashpole NM Song W Brustovetsky T 2012J Biol Chem2012,287,11:1
5Whole brain radia- tion-induced vascular cognitive impairment: mechanisms and implications显示文摘Warrington JP Ashpole N Csiszar A 2013J Vasc Res2013,50,6:1
6Calcium/ calmodulin-dependent protein kinase II (caMK II ) inhibition induces neurotoxicity via dysregulation of glutamate/calcium signaling and hyperexcitability显示文摘Ashpole NM Song W Brustovetsky T 2012J Biol Chem2012,,:1
7Reference ranges for thromboelastography (TEG) and traditional co- agulation tests in term parturients undergoing caesarean section under spinal anaesthesia 显示文摘Macafee B Campbell JP Ashpole K 2012Anaesthesia2012,67,7:1
8Remifentanil sedation for awake fibreoptic intubation with limited application of local anaesthetic in patients for elective head and neck surgery 显示文摘Mingo OH Ashpole KJ Irving CJ 2008Anaesthesia2008,63,10:1
9Whole brain radiation-induced vascular cognitive impair-ment:mechanisms and implications显示文摘Warrington JP Ashpole N Csiszar A Lee YW Ungvari Z Sonntag WE 0,,:1
10Remifentanil sedation for awake fibreoptic intubation with limited application of local anaesthetic in patients for elective head and neck surgery显示文摘Mingo OH Ashpole KJ Irving CJ 2008Anaesthesia2008,63,10:1
11Whole brain radiation- in- duced vascular cognitive impairment:Mechanisms and implications 显示文摘Warrington JP Ashpole N Csiszar A 2013J Vase Res2013,50,6:1
12Reference ranges for thromboelastography(TEG) and traditional coagulation tests in term parturients undergoing caesarean section under spinal anaes- thesia显示文摘Macafee B Campbell JP Ashpole K 2012Anaesthesia2012,67,7:1
13Maternal Cardiac Output Changes After Crystalloid or Colloid Coload Following Spinal Anesthesia for Elective Cesarean Delivery: A Randomized Controlled Trial显示文摘Sarah McDonald Roshan Fernando Keri Ashpole Malachy Columb 2011Anesthesia & Analgesia2011,,4:1
14Maternal cardiac output changes after crystalloid or colloid coload following spinal anesthesia for elective cesarean delivery: a randomized controlled trial显示文摘McDonald S Fernando R Ashpole K 2011Anesth Analg2011,113,4:1
15Reference ranges for thromboelastography (TEG (R)) and traditional coagulation tests in term parturients undergoing caesarean section under spinal anaesthesia显示文摘Maeafee B Campball J-P Ashpole K 2012Anaesthesia2012,67,7:1
16Remifentanil se-dation for awake fibreoptic intubation with limited applica-tion of local anaesthetic in patients for elective head and necksurgery显示文摘Mingo OH Ashpole KJ Irving CJ 2008Anaesthesia2008,63,10:1
17Small molecule inhibitors of PSD95-nNOS protein-protein interactions as novel analgesics 显示文摘LEE WH XU Z ASHPOLE NM 2015Neuropharmacology2015,97,:1
18Maternal cardiac output changes after crystalloid or colloid coload following spinal anesthesia for elective cesarean delivery:a randomized controlled trial显示文摘McDonald S Fernando R Ashpole K 2011Anesth Analg2011,113,4:1
19Assessment of coagulation in the obstetric population using TROTEMthromboelastometry显示文摘Armstrong S Fernando R Ashpole K 2011Int J Obstet Anesth2011,20,4:1
20Reference ranges for thromboelastography(TEG)and traditional coagulation tests in term parturients undergoing caesarean section under spinal anaesthesia显示文摘Macafee B Campbell JP Ashpole K 2012Anaesthesia2012,67,7:1
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