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| 1 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 2 | Factors influencing bicycle crash severity on two-lane,undivided roadways in north carolina显示文摘 | Jeremy R Klop Asad J Khattak | 1999 | Transportation Research Record1999，，1674： | 1 |
| 3 | Pretreatment and utilization of raw glycerol from sunflower oil biodiesel for growth and 1,3-propanediol production by Clostridium Butyricum显示文摘 | Asad ur Rehman Saman Wijesekara R G Nakao Nomura | | 0，，07： | 1 |
| 4 | Enhanced lignin peroxidase synthesis by Phanerochaete chrysosporium in solid state bioprocessing of a lignocellulosic substrate显示文摘 | Asgher M Asad M J Legge R L | | 0，，05： | 1 |
| 5 | In vivo degradation of collagen barrier membranes exposed to the oral cavity显示文摘 | Klinger A Asad R Shapira L | 2010 | Clin Oral Implan Res2010，21，8： | 1 |
| 6 | A Tree Projection Algorithm for Generation of Frequent Itemsets显示文摘 | Agarwal R Aggrawal C V V V P/asad | 2000 | Journal of parallel and Distributed Computing2000，，： | 1 |
| 7 | Pharmacotherapy for meconium aspiration显示文摘 | Asad A Bhat R | 2008 | J Perinatol2008，28，3： | 1 |
| 8 | Primary Anastomosis in the management of acute sigmoid volvulus without colonic lavage显示文摘 | Mumtaz Khan Saf/r UHah Mian Asad | 2007 | JPM12007，2，4： | 1 |
| 9 | Greener Data Exchange in the Cloud A Coding-based Optimization for Big Data Processing显示文摘 | Asad Z Chaudhry M A R Malone D | 2016 | IEEE Journal on Selected Areas in Communications2016，34，05： | 1 |
| 10 | Prevalence of anxiety,depression and associated factors among pregnant women of Hyderabad,Pakistan 显示文摘 | Karmaliani R Asad N Bann C M | 2009 | Int J Soc psychiatry2009，55，5： | 1 |
| 11 | Prevalence of anxiety,depression and associated factors among pregnant women of Hyderabad,Pakistan显示文摘 | Karmaliani R Asad N Bann CM | 2009 | Int J Soc Psychiatry2009，55，5： | 1 |
| 12 | A heuristic approach to stochastic cutoff grade optimization for open pit mining complexes with multiple processing streams 显示文摘 | ASAD M DIMITRAKOPOULOS R | 2013 | Resources Policy2013，38，4： | 1 |
| 13 | Prevalenee of anxiety, depression and associated factors among pregnant women of Hyderabad,Pakistan 显示文摘 | Karmaliani R Asad N Bann C M | 2009 | Int J Soc psychiatry2009，55，5： | 1 |
| 14 | CMOS comes of age显示文摘 | Asad A Abidi R F | 2004 | IEEE Journal of Solid-state Circuits2004，39，4： | 1 |
| 15 | Infinite network of identical capacitors by Green' s function 显示文摘 | Asad J H Sakaji A J Hijjawi R S | 2005 | Int J Mod Phys B2005，24，19： | 1 |
| 16 | Perturbation of an infinite network of identical capacitors显示文摘 | Hijjawi R S Asad J H Sakaji A J | 2007 | Int J Mod Phys B2007，21，2： | 1 |
| 17 | A heuristic approach to stochastic cutoff grade optimization for open pit mining complexes with multiple processing streams 显示文摘 | ASAD M DIMITRAKOPOULOS R | 2013 | Resources Policy2013，38，4： | 1 |
| 18 | The diagnosis of growth hormone deficiency in children and adults 显示文摘 | Stephen MS Andrew T Asad R | 1998 | Endocrine Reviews1998，19，2： | 1 |
| 19 | Use of radiation and in vitro techniques for development of salt tolerant mutants in sugarcane and potato显示文摘 | Saif U R Rashid M Asad S | 2001 | IAEA-tecdoc 12272001，，： | 1 |
| 20 | Production scheduling in steel rolling mills with demand substitution:Rolling horizon implementation and approximations显示文摘 | ASAD R DEMIRLI K | 2010 | International Journal of Production Economics2010，126，2： | 1 |
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