|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer’s disease and dementia with Lewy bodies显示文摘Background:Because of the increasing life expectancy in our society,aging-related neurodegenerative disorders are one of the main issues in global health.Most of these diseases are characterized by the deposition of misfolded proteins and a progressive cognitive decline.Among these diseases,Alzheimer’s disease(AD)and dementia with Lewy bodies(DLB)are the most common types of degenerative dementia.Although both show specific features,an important neuropathological and clinical overlap between them hampers their correct diagnosis.In this work,we identified molecular biomarkers aiming to improve the misdiagnosis between both diseases.Methods:Plasma extracellular vesicles(EVs)-from DLB,AD and healthy controls-were isolated using size-exclusion chromatography(SEC)and characterized by flow cytometry,Nanoparticle Tracking Analysis(NTA)and cryo-electron microscopy.Next Generation Sequencing(NGS)and related bibliographic search was performed and a selected group of EV-associated microRNAs(miRNAs)was analysed by qPCR.Results:Results uncovered two miRNAs(hsa-miR-451a and hsa-miR-21-5p)significantly down-regulated in AD samples respect to DLB patients,and a set of four miRNAs(hsa-miR-23a-3p,hsa-miR-126-3p,hsa-let-7i-5p,and hsamiR-151a-3p)significantly decreased in AD respect to controls.The two miRNAs showing decreased expression in AD in comparison to DLB provided area under the curve(AUC)values of 0.9 in ROC curve analysis,thus suggesting their possible use as biomarkers to discriminate between both diseases.Target gene analysis of these miRNAs using prediction online tools showed accumulation of phosphorylation enzymes,presence of proteasome-related proteins and genes involved in cell death among others.Conclusion:Our data suggest that plasma-EV associated miRNAs may reflect a differential profile for a given dementia-related disorder which,once validated in larger cohorts of patients,could help to improve the differential diagnosis of DLB versus AD. | Ana Gámez-Valero Jaume Campdelacreu Dolores Vilas Lourdes Ispierto Ramón Reñé RamiroÁlvarez MPilar Armengol Francesc E.Borràs Katrin Beyer | 2019 | Translational Neurodegeneration2019，8，1： | 4 |
| 2 | Laparoscopy-assisted versus open colectomy for treatment of colon cancer in the elderly: morbidity and mortality outcomes in 545 patients显示文摘 | Francesc Vallribera Valls Filippo Landi Eloy Espín Basany José Luis Sánchez García Luis Miguel Jiménez Gómez Marc Martí Gallostra Luis Salgado Cruz Manuel Armengol Carrasco | 2014 | Surgical Endoscopy2014，，12： | 2 |
| 3 | The injection of plasmid DNA in mouse muscle results in lifelong persistence of DNA, gene expression, and humoral response显示文摘 | Armengol G Ruiz L M Orduz S | 2004 | Mol Biotechnol2004，27，2： | 1 |
| 4 | Regulation of replica-tive and stress-induced senescence by RSK4, which is down-regu-lated in human tumors 显示文摘 | L6pez-Vicente L Armengol G Pons B | 2009 | Clin Cancer Res2009，15，14： | 1 |
| 5 | Genetic changes including gene copy number alterations and their relation to prognosis in childhood acute myeloid leukemia显示文摘 | Armengol G Canellas A Alvarez Y | 2010 | Leuk Lymphoma2010，51，1： | 1 |
| 6 | Recurrent gains of 1q,8 and 12 in the Ewing family of tumours by comparative genomic hybridization显示文摘 | Armengol G Tarkkanen M Virolainen M | 1997 | Br J Cancer1997，75，10： | 1 |
| 7 | Effects of snoring and obstructive respiratory events on sleep architecture in adolescents显示文摘 | Fuentes Pradera MA Botebol G Sanchez Armengol A | | 0，，7： | 1 |
| 8 | Identification, inci- dence and characterization of Fusarium proliferatum on orna- mental palms in Spain 显示文摘 | Armengol J Moretti A Perrone G | 2005 | European Journal of Plant Pathology2005，112，2： | 1 |
| 9 | The thermal structure of Sau Reservoir ( NE: Spain) : a simulation approach 显示文摘 | HAN B P ARMENGOL J CARLOS G J | 2000 | Ecological M odelling2000，125，23： | 1 |
| 10 | Role of Toll-like receptors 2 and 4 in mediating endothelial dysfunction and arterial remodeling in primary arterial antiphospholipid syndrome显示文摘 | Benhamou Y Bellien J Armengol G | 2014 | Arthritis Rheumatol2014，66，11： | 1 |
| 11 | Long-lasting effects of a Bacillus thuringiensis serovar israelensis experimental tablet formulation for Aedes aegypti (Diptera: Culicidae) control 显示文摘 | Armengol G Hernandez J Velez JG | 2006 | J Econ Entomol2006，99，5： | 1 |
| 12 | 4E-binding protein 1:a key molecular“funnel factor”in human cancer with clinical implications显示文摘 | Armengol G Rojo F Castellvi J | 2007 | Cancer Res2007，67，16： | 1 |
| 13 | Regulationof replicative and stress induced senescence by RSK4,which is down regulated in human tumors 显示文摘 | Lopez Vicente L Armengol G Pons B | 2009 | ClinCancer Res2009，15，14： | 1 |
| 14 | Regulation of replieative and stress-induced senescence by RSK4,which is downregulated in human mmors显示文摘 | Lopez-Vicente L Armengol G Pons B | 2009 | Clin Cancer Res2009，15，14： | 1 |
| 15 | Regulation of repli- cative and stress-induced senescence by RSK4, which is down-reg- ulated in human tumors 显示文摘 | Lopez-Vieente L Armengol G Pons B | 2009 | Clin Cancer Res2009，15，14： | 1 |
| 16 | Regulation of replicative and stress-induced senescence by RSK4, which is down-regulated in human tumors显示文摘 | Lopez-Vieente L Armengol G Pons B | 2009 | Clin Cancer Res2009，15，14： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员