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	题名	作者	年代	出处	被引量
1	神经生长因子增强小胶质细胞的神经保护作用显示文摘小胶质细胞是脑组织内的防御细胞,但在病理和生理条件下,调控小胶质细胞活化的因子并不十分清楚。本研究发现,神经生长因子(NGF)可以增强小胶质细胞的神经保护和抗炎功能。在体内和体外研究中都发现,小胶质细胞表达NGF受体。原代培养小胶质细胞,给予NGF处理,转录本分析结果显示,NGF对小胶质细胞的运动、吞噬和降解吞噬物的能力均产生影响。对功能的研究显示,NGF可增加小胶质细胞的膜运动能力和胞饮作用;在体研究显示,NGF可激活小胶质细胞释放向外整流电流,调节周围谷氨酸能神经元的神经传递。既往研究提示,小胶质细胞有清除脑内Aβ肽的功能,本研究观察了NGF对小胶质细胞吞噬能力的影响。结果显示,NGF可促进小胶质细胞通过Trk A途径清除Aβ,并加速其降解。此外,NGF还可减轻由Aβ导致的炎症激活。特异性激活小胶质细胞还可以减轻由Aβ导致的神经元树突损伤和长时程增强抑制。在对离体脑片的研究中,我们也发现NGF可以促进小胶质细胞吞噬Aβ。综上所述,本研究证实NGF可以促进小胶质细胞活化,活化的小胶质细胞通过抗炎作用减轻Aβ聚集,发挥神经保护作用。	唐颖馨 Rizzi C Tiberi A Giustizieri M Marrone MC Gobbo F Carucci NM Meli G Arisi I D'Onofrio M Marinelli S Capsoni S Cattaneo A	2018	神经损伤与功能重建2018，13，2：	2
2	Prognostic significance of P27 and cyclin D1 co-expression in laryngeal squamous cell carcinoma:possible target for novel therapeutic strategies显示文摘	ARISI E PRUNERI G CARBONI N	2004	J Chemother2004，16，5：	1
3	Soluble Fas and soluble Fas ligand balance in laryngeal carcinoma before and after surgical treatment 显示文摘	Pignataro L Arisi E Sambataro G	2003	J Surg Oncol2003，83，2：	1
4	Glutathione,biosynthesis,metabolism and relationship to stress tolerance explored in transformed plants显示文摘	Noctor G Arisi A C Jouanin L	1998	J Exp Bot1998，49，：	1
5	Preliminary results obtained with short dialysis schedules显示文摘	Cambi V Arisi L Bignardi L	1975	Ateneo Parmense Acta Biomed1975，46，5：	1
6	Primary non-Hodgkins lymphoma of the kidney显示文摘	Paganelli E Arisi L Ferrari M E	1989	Haematologica1989，74，3：	1
7	Temozolomide and radiotherapy as first-line treatment of high-grade gliomas显示文摘	Arisi S Raguso A	2006	Tumori2006，92，4：	1
8	Overexpression of iron siperoxide dismutase in transformed poplar modifies the regulation of photosynthesis at low CO2 partial pressures of following exposure to the prooxidant herbicide methyl viologen 显示文摘	Arisi A-CM Comic G Jouanin L	1998	Plant Physiol1998，117，2：	1
9	Gene expression biomarkers in the brain of a mouse model for Alzheimer ' s disease:mining of microarray data by logic classification and feature selection显示文摘	Arisi I D ' Onofrio M Brandi R		0，，04：	1
10	Manipulation of glutathione and amino acid biosynthesis in the chloroplast显示文摘	Noctor G Arisi A C M Jouanin L	1998	Plant Physiol1998，118，：	1
11	Doublecortin-positive newly born granule cells of hippocampus have abnormal apical dendritic morphology in the pilocarpine model of temporal lobe epilepsy显示文摘	Arisi GM Garcia-Cairasco N	2007	Brain Res2007，1165，：	1
12	Primary non-Hodgkin lymphoma of the kidney显示文摘	Paganelli E Arisi L Ferrari ME	1989	Hematology1989，74，：	1
13	Manipulation of glutathione and amino acid biosynthesis in the chloroplast 显示文摘	NOCTOR G ARISI A C M JOUANIN L	1998	Plant Physiology1998，118，：	1
14	Correlation between shaking behaviors and seizure severity in five animal models of convulsive seizures显示文摘	Rodrigues MC Rossetti F Foresti ML Arisi GM Furtado MA Dal-Có1 ML Bertti P Fernandes A Santos FL Del Vecchio F Garcia-Cairasco N		0，，03：	1
15	Dysregulated mi- croRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation显示文摘	PARISI C ARISI I D'AMBROSI N l	2013	Cell Death Disease2013，4，959：	1
16	Over-expression of Fe-SOD in transformed poplar modifies the regulation of photosynthesis at low CO2 partial pressures or following exposure to the prooxidant hebicide methyl viologen显示文摘	Arisi A C Cornic G Jouanin L	1998	Plant Physiol1998，117，：	1
17	Overexpression of iron siperoxide dismutase in transformed poplar modifies the regulation of photosynthesis at low CO2 partial pressures of following exposure to the prooxidant herbicide methyl viologen显示文摘	ARISI A C M CORNIC G JOUANIN L	1998	Plant Physiol1998，117，2：	1
18	Overexpression of iron superoxide dismutase in transformed poplar modifies the regulation of photosynthesis at low CO2 partial pressures or following exposure to the prooxidant herbicide methyl viologen显示文摘	ARISI A C CORNIC G JOUANIN L	1998	Plant Physiology1998，117，2：	1
19	Gene expression biomarkers in the brain of a mouse model for Alzheimer's disease: mining of microarray data by logic classification and feature selection 显示文摘	Ivan Arisi Mara D'Onofrio Rossella Brandi	2011	J Alzheimer''s Dis2011，24，4：	1
20	Outbreak of acute renal failure due tocefodizime-vancomycin association in a heart surgery unit显示文摘	Fiaccadori E Maggiore U Arisi A	2002	Intensive Care Med2002，27，：	1

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