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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | Variceal band ligation and variceal bleeding in cirrhotic patients: a randomized,prospective and cotrolled trial显示文摘 | Argonz J Kravelz D Suarez A etal | 2003 | Gastrointest Endosc2003，51，2： | 1 |
| 3 | Patients with ascites have higher varceal pressure and wall tension than patients without ascites显示文摘 | Kravetz D Bildozola M Argonz J | 2000 | Am J Gastroentrol2000，95，7： | 1 |
| 4 | Terlipressin is more effective-indecreasing variceal pressure than portal pressure in cirrhotic patients 显示文摘 | Romero G Kravetz D Argonz J | 2000 | J Hepatol2000，32，3： | 1 |
| 5 | Terlipressin is more effective in decreasing variceal pressure than portal pressure in cirrhotic patients显示文摘 | Romero G Kravetz D Argonz J | | 0，，01： | 1 |
| 6 | Pa- tients with ascites have higher varieeal pressure and wall tension than patients without ascites 显示文摘 | Kravetz D Bildozola M Argonz J | 2010 | Am J Gastroenterol2010，95，7： | 1 |
| 7 | Total volume paracentesis decreases variceal pressure, size,and variceal wall tension in cirrhotic patients 显示文摘 | Kravetz D Romero G Argonz J | 1997 | Hepatology1997，25，1： | 1 |
| 8 | Patients with ascites have higher variceal pressure and wall tension than patients without ascites显示文摘 | Kravetz D Bildozola M Argonz J | 2000 | Am J Gastroenterol2000，95，7： | 1 |
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