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| 1 | Evaluation of Medium Components by Plackett-Burman Statistical Design for Lipase Production by Candida rugosa and Kinetic Modeling显示文摘Lipase production by Candida rugosa was carried out in submerged fermentation.Plackett-Burman statisticalexperimental design was applied to evaluate the fermentation medium components.The effect of twelve medium components was studied in sixteen experimental trials.Glucose,olive oil,peptone and FeCl3·6H2O were found to have more significance on lipase production by Candida rugosa.Maximum lipase activity of 3.8 u mL-1 was obtained at 50h of fermentation period.The fermentation was carried out at optimized temperature of 3℃,initial pH of 6.8 and shaking speed of 120 r/min.Unstructured kinetic models were used to simulate the experimental data.Logistic model,Luedeking-Piret model and modified Luedeking-Piret model were found suitable to efficiently predict the cell mass,lipase production and glucose consumption respectively with high determination coefficient(R2).From the estimated values of the Luedeking-Piret kinetic model parameters,α and β,it was found that the lipase production by Candida rugosa is growth associated. | Aravindan Rajendran Anbumathi Palanisamy Viruthagiri Thangavelu | 2008 | 生物工程学报2008，24，3： | 9 |
| 2 | MicroRNAs in neuroblastoma tumorigenesis,therapy resistance,and disease evolution显示文摘Neuroblastoma(NB)deriving from neural crest cells is the most common extra-cranial solid cancer at infancy.NB originates within the peripheral sympathetic ganglia in adrenal medulla and along the midline of the body.Clinically,NB exhibits significant heterogeneity stretching from spontaneous regression to rapid progression to therapy resistance.MicroRNAs(miRNAs,miRs)are small(19-22 nt in length)non-coding RNAs that regulate human gene expression at the post-transcriptional level and are known to regulate cellular signaling,growth,differentiation,death,stemness,and maintenance.Consequently,the function of miRs in tumorigenesis,progression and resistance is of utmost importance for the understanding of dysfunctional cellular pathways that lead to disease evolution,therapy resistance,and poor clinical outcomes.Over the last two decades,much attention has been devoted to understanding the functional roles of miRs in NB biology.This review focuses on highlighting the important implications of miRs within the context of NB disease progression,particularly miRs’influences on NB disease evolution and therapy resistance.In this review,we discuss the functions of both the“oncomiRs”and“tumor suppressor miRs”in NB progression/therapy resistance.These are the critical components to be considered during the development of novel miR-based therapeutic strategies to counter therapy resistance. | Natarajan Aravindan Karthikeyan Subramanian Dinesh Babu Somasundaram Terence S.Herman Sheeja Aravindan | 2019 | Cancer Drug Resistance2019，2，4： | 3 |
| 3 | Experimental Investigation on Friction Welding of UNS S32205 Duplex Stainless Steel显示文摘UNS S 32205 duplex stainless steel specimens were joined by continuous drive friction welding process. The experiments were conducted as per the Taguchi(L16 orthogonal array) method. The friction welding process parameters such as heating pressure, heating time, upsetting pressure, upsetting time, and speed of rotation were fixed with low,medium, and high levels of range based on the machine capacity, and the required knowledge was acquired from the preliminary experiments. The joint characterization studies included micro structural examination and evaluation of mechanical properties of the joints. Microhardness variation, impact toughness, and tensile strength of the joints were evaluated. Neither a crack nor an incomplete bonding zone was observed. The tensile strength of the joints was higher than the strength of the base material, and the friction and upsetting pressures were found to influence the joint strength. The tensile strength of all the welds was observed to be increasing with an increase in the rotational speed. The toughness of the friction welds was evaluated at room temperature and also at subzero(cryo) temperature conditions. The toughness for friction welds was found to be superior to the fusion welds of duplex stainless steel at room temperature and cryo conditions. Weldments exhibited better corrosion resistance than the parent material. | P. M. Ajith P. Sathiya S. Aravindan | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，6： | 3 |
| 4 | Characterization of microstructure, toughness, and chemical composition of friction-welded joints of UNS S32205 duplex stainless steel显示文摘Friction welding is a solid-state joining process which is applied extensively because of its advantages such as low heat input,efficient application,ease in manufacturing,and environmental friendliness.The present study investigates the mechanical and metallurgical properties of UNS S32205 duplex stainless steel friction-welded joints.The process parameters,namely friction pressure,upsetting pressure,and rotational speed are individually varied from low level to high level(within the range of the machine setup)and their effects on the joint properties are analyzed.The partial-deformation zone had higher hardness than the weld and base metal.The toughness of the joints was evaluated at room temperature and at subzero temperature conditions.The impact toughness of the friction-welded joints was found to be superior to fusion-joined duplex stainless steel in room and cryogenic conditions. | Puthuparambil Madhavan AJITH Paulraj SATHIYA Sivanandam ARAVINDAN | 2014 | Friction2014，2，1： | 2 |
| 5 | A comparative evaluation of assembly line balancing heuristics显示文摘 | Ponnambalam S G Aravindan P Mogileeswar Naidu G | 1999 | The International Journal of Advanced Manufacturing Technology1999，，15： | 2 |
| 6 | Metallurgical Behaviour and Carbon Diffusion in Buttering Deposits Prepared With and Without Buffer Layers显示文摘Use of a buttering deposit on ferritic steel in dissimilar metal weld(DMW) joint is a common practice in nuclear plants to connect pressure vessel components(ferritic steel) to pipelines(austenitic stainless steel).Carbon migration and metallurgical changes near fusion interface(ferritic steel–austenitic stainless steel) lead to a steeper gradient in material properties,and minimizing this gradient is the major challenge in the manufacturing of DMW joints.Inconel 82 is often deposited on ferritic steel material as buttering to reducing the gradient of physical and attaining material compatibility.Inconel 82/182 fillers are used to minimize the carbon migration,but the results are not truly adequate.In this paper,Ni–Fe alloy(chromium-free) has been used as the intermediate buffer layer in the weld buttering deposit to address the issue of carbon migration and subsequent metallurgical deterioration.The weld pads with and without buffer layers of Ni–Fe alloy have been investigated and compared in detail for metallurgical properties and carbon diffusivities.Ni–Fe buffer layer can significantly control the carbon migration which resists the metallurgical deterioration.It showed the better results in postweld heat treatment and thermally aged conditions.The buttering deposit with Ni–Fe buffer layer could be the better choice for DMW joints requirements. | Dinesh W.Rathod Sunil Pandey Sivanandam Aravindan Pavan Kumar Singh | 2017 | Acta Metallurgica Sinica(English Letters)2017，30，2： | 2 |
| 7 | Some experimental investiga- tions on friction welded stainless steel joints 显示文摘 | Sathiya P Aravindan S Haq A N | 2008 | Materials and Design2008，29，6： | 1 |
| 8 | Activated carbons derived from coconut shells as high energy density cathode material for Li-ion capacitors显示文摘 | JAIN A ARAVINDAN V JAYARAMAN S | 2013 | Sci Rep2013，3，： | 1 |
| 9 | Zr02 nanofiller incorpo- rated PVC/PVdF blend-based composite polymer electrolytes (CPE) complexed with LiBOB显示文摘 | Aravindan V Vickraman P Kumar P | 2007 | Journal of Membrane Sci- ence2007，305，12： | 1 |
| 10 | Carbon supported, Al doped-Li3V2(PO4)3 as a high rate cathode material for lithium-ion batteries显示文摘 | CHO A R SON J N ARAVINDAN V | 2012 | Journal of Materials Chemistry2012，22，14： | 1 |
| 11 | Predictors of mortality inacute renal failure in a developing counry : a prospective study显示文摘 | Kohli HS Bhat A Aravindan AN | 2007 | Renal Failure2007，29，46： | 1 |
| 12 | 锐钛型钛二氧化物纳米颗粒对小鼠的影响:证据表明短时间而不是长时间的暴露会导致小鼠精子结构和功能的异常显示文摘锐钛型钛二氧化物纳米颗粒(TNPs)广泛应用在商业领域,并且存在于不同的产品中。为明确更小剂量的锐钛型钛二氧化物纳米颗粒(ATNPs)间隔一定距离进入体内到达阴囊后是否能诱导精子缺陷的发生,雄性成年小鼠持续3天腹腔内注射100%ATNP(2.5或5mg/kg),然后在注射后1周、2周、3周或5周(长时间暴露)或者是注射后24小时、48小时或120小时(短时间暴露)处死。透射电镜表明在注射后120小时收集到的阴囊脂肪组织中,附睾组织和附睾液均出现炎症反应。在注射后120小时和3周后,睾丸组织间质间隙增大。利用末端脱氧核糖核酸转移酶介导的缺口末端标记技术发现在注射后的雄鼠体内阳性(即凋亡)精子(P=0.002)和间质细胞(P=O.04)数目均显著增加。与对照组相比,短时间暴露而不是长时间暴露的附睾尾部精子鞭毛异常、过量胞浆残余(ERC)的发生率增加,精子无顶体反应的发生率增加(呈剂量依赖性)。ERC与无顶体反应是否存在相关性目前尚不清楚。与对照组相比,暴露120小时组快速运动精子数量和线粒体膜电位均显著下降(P〈0.05),同时,活性氧水平显著增加(P〈0.00001)。这些结果表明在注射后4.8天,ANTP能够引发不育的精子结构和功能的异常,并且通过氧化应激造成DNA的损伤。同时,在暴露后的10天到5周末检测到精子的异常,这表明精子的这种异常是暂时性的。 | Michelle A Smith Rowan Michael Rolands G Aravindan Soma Dash Syed I Shah Deni S Galileo Patricia A Martin-DeLeon | 2015 | Asian Journal of Andrology2015，17，2： | 1 |
| 13 | 查看详情显示文摘 | Aravindan V Gnanaraj Madhavi S | | 0，，51： | 1 |
| 14 | Adipic acid assisted sol-gel synthesis of Li2MnSiO4 nanoparticles with improved lithium storage properties显示文摘 | Aravindan V Karthikeyan K Ravi S | | 0，，35： | 1 |
| 15 | Electrochemical per- formance of Nasicon type carbon coated LiTi2( PO4 )3 with a spinel LiMnO4 cathode显示文摘 | ARAVINDAN V WANG C L MADHAVI S | 2012 | RSC Advances2012，，2： | 1 |
| 16 | Influence of carbon towards improved lithium storage properties of Li2MnSiO4 cathodes显示文摘 | Aravindan V Karthikeyan K Kang K S | | 0，，08： | 1 |
| 17 | Improved Elevated Temperature Performance of Al-intercalated V205 Electrospun Nanofibers for Lithium- ion Batteries 显示文摘 | Cheah YL Aravindan V Madhavi S | 2012 | A CS Applied Materials & lnteoCaces2012，，4： | 1 |
| 18 | Citric acid as a feed stimulant 显示文摘 | Aravindan C M | 1997 | Fish Techol Soc Fish Technol India1997，34，1： | 1 |
| 19 | Dynamic simulation of job shop sched- uling for optimal performance 显示文摘 | SELLADURA V ARAVINDAN P PONNAMBAL-AM S G | 1995 | International Jour- nal of Operations & Production Management1995，15，7： | 1 |
| 20 | Electrochemical lithium insertion behavior of combustion synthesized V2 O3 cathodes for lithium-ion batteries 显示文摘 | Cheah Y L Aravindan V Madhavia S | 2012 | Journal of the Electrochemical Society2012，159，3： | 1 |
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