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| 1 | Developmental dysplasia of the hip in the newborn: A systematic review显示文摘Developmental dysplasia of the hip(DDH) denotes a wide spectrum of conditions ranging from subtle acetabular dysplasia to irreducible hip dislocations. Clinical diagnostic tests complement ultrasound imaging in allowing diagnosis, classification and monitoring of this condition. Classification systems relate to the alpha and beta angles in addition to the dynamic coverage index(DCI). Screening programmes for DDH show considerable geographic variation; certain risk factors have been identified which necessitate ultrasound assessment of the newborn. The treatment of DDH has undergone significant evolution, but the current gold standard is still the Pavlik harness. Duration of Pavlik harness treatment has been reported to range from 3 to 9.3 mo. The beta angle, DCI and the superior/lateral femoral head displacement can be assessed via ultrasound to estimate the likelihood of success. Success rates of between 7% and 99% have been reported when using the harness to treat DDH. Avascular necrosis remains the most devastating complication of harness usage with a reported rate of between 0% and 28%. Alternative non-surgical treatment methods used for DDH include devices proposed by LeD amany, Frejka, Lorenz and Ortolani. The Rosen splint and Wagner stocking have also been used for DDH treatment. Surgical treatment for DDH comprises open reduction alongside a combination of femoral or pelvic osteotomies. Femoral osteotomies are carried out in cases of excessive anteversion or valgus deformity of the femoral neck. The two principal pelvic osteotomies most commonly performed are the Salter osteotomy and Pemberton acetabuloplasty. Serious surgical complications include epiphyseal damage, sciatic nerve damage and femoral neck fracture. | Vivek Gulati Kelechi Eseonu Junaid Sayani Nizar Ismail Chika Uzoigwe Muhammed Zaki Choudhury Pooja Gulati Adeel Aqil Saket Tibrewal | 2013 | World Journal of Orthopedics2013，4，2： | 29 |
| 2 | Effect of Salicylic Acid on Salinity-induced Changes in Brassica juncea显示文摘Seeds of Indian mustard (Brassica juncea (L.) Czern. et Coss.) were exposed to 0, 50, 100 and 150 mmol/L NaCl for 8 h and seeds were sown in an earthen pot. These stressed seedlings were subsequently sprayed with 10 μmol/L salicylic acid (SA) at 30 d and were sampled at 60 d to assess the changes in growth, photosynthesis and antioxidant enzymes. The seedlings raised from the seeds treated with NaCl had significantly reduced growth and the activities of carbonic anhydrase, nitrate reductase and photosynthesis, and the decrease was proportional to the increase in NaCl concentration. However, the antioxidant enzymes (catalase, peroxidase and superoxide dismutase) and proline content was enhanced in response to NaCl and/or SA treatment, where their interaction had an additive effect. Moreover, the toxic effects generated by the lower concentration of NaCl (50 mmol/L) were completely overcome by the application of SA. It was, therefore, concluded that SA ameliorated the stress generated by NaCl through the alleviated antioxidant system. | Mohammad Yusuf Syed Aiman Hasan Barket Ali Shamsul Hayat Qazi Fariduddin Aqil Ahmad | 2008 | Journal of Integrative Plant Biology2008，50，9： | 16 |
| 3 | Abnormal ground reaction forces lead to a general decline in gait speed in knee osteoarthritis patients显示文摘AIM To analyse ground reaction forces at higher speeds using another method to be more sensitive in assessing significant gait abnormalities. METHODS A total of 44 subjects, consisting of 24 knee osteoarthritis(OA) patients and 20 healthy controls were analysed. The knee OA patients were recruited from an orthopaedic clinic that were awaiting knee replacement. All subjects had their gait patterns during stance phase at top walking speed assessed on a validated treadmill instrumented with tandem force plates. Temporal measurements and ground reaction forces(GRFs) along with a novel impulse technique were collected for both limbs and a symmetry ratio was applied to all variables to assess inter-limb asymmetry. All continuous variables for each group were compared using a student t-test and χ2 analysis for categorical variables with significance set at α = 0.05. Receiver operator characteristics curves were utilised to determine best discriminating ability.RESULTS The knee OA patients were older(66 ± 7 years vs 53 ± 9 years, P = 0.01) and heavier(body mass index: 31 ± 6 vs 23 ± 7, P < 0.001) but had a similar gender ratio when compared to the control group. Knee OA patients were predictably slower at top walking speed(1.37 ± 0.23 m/s vs 2.00 ± 0.20 m/s, P < 0.0001) with shorter mean step length(79 ± 12 cm vs 99 ± 8 cm, P < 0.0001) and broader gait width(14 ± 5 cm vs 11 ± 3 cm, P = 0.015) than controls without any known lower-limb joint disease. At a matched mean speed(1.37 ± 0.23 vs 1.34 ± 0.07), ground reaction results revealed that pushoff forces and impulse were significantly(P < 0.0001) worse(18% and 12% respectively) for the knee OA patients when compared to the controls. Receiver operating characteristic curves analysis demonstrated total impulse to be the best discriminator of asymmetry, with an area under the curve of 0.902, with a cut-off of-3% and a specificity of 95% and sensitivity of 88%.CONCLUSION Abnormal GRFs in knee osteoarthritis are clearly evident at higher speeds. Analysing GRFs with another method may explain the general decline in knee OA patient's gait. | Anatole Vilhelm Wiik Adeel Aqil Mads Brevadt Gareth Jones Justin Cobb | 2017 | World Journal of Orthopedics2017，8，4： | 7 |
| 4 | Development of a chitosan nanofibrillar scaffold for skin repair and regeneration 显示文摘 | Tchemtchoua VT Atanasova G Aqil A | 2011 | Biomacromolecules2011，12，9： | 1 |
| 5 | Metal tolerance and biosorption potential of filamentous fungi isolated from metal contaminated agricultural soil 显示文摘 | Zafar S Aqil F Abroad I | 2007 | Bioresource Technology2007，98，13： | 1 |
| 6 | Sparfloxacin-loaded PLGA nanoparticles for sustained ocular drug delivery显示文摘 | Gupta H Aqil M Khar RK | | 0，，： | 1 |
| 7 | Ben3 anthocyanidins synergistically suppress growth and invasive potential of human non- small- cell lung cancer cells 显示文摘 | Kausar H Jeyabalan J Aqil F | 2012 | Cancer Letters2012，325，1： | 1 |
| 8 | Microemulsions as a surrogate carrier for dermal drug delivery 显示文摘 | AZEEM A KHAN Z I AQIL M | 2009 | Drug Dev Ind Pharm2009，35，5： | 1 |
| 9 | Preparation of stable suspensions of gold nanoparticles in water by sonoelectrochemistry显示文摘 | Aqil A Serwas H Delplancke J L | 2008 | Ultrasonics Sonochemistry2008，15，6： | 1 |
| 10 | Inhibition of Estrogen -Mediated Mammary Tumorigenesis by Blueberry and Black Raspberry显示文摘 | Ravoori S Vadhanam M V Aqil F et a/ | 2012 | J Agric Food Chem2012，60，22： | 1 |
| 11 | Adipocytokines in subjects with and without ischemic cerebrovascular disease显示文摘 | Jaleel A Aqil S Jaleel S | 2010 | Acta Neurologica Bel- giea2010，110，3： | 1 |
| 12 | Advanced drug deliverysystems of curcumin for cancer chemoprevention 显示文摘 | Bansal S S Goel M Aqil F | 2011 | Cancer Prev Res (Phila)2011，4，8： | 1 |
| 13 | Biodegradable levofloxaein nanoparticles for sustained ocular drug delivery 显示文摘 | Gupta H Aqil M Khar RK | 2011 | Journal of Drug Targeting2011，19，6： | 1 |
| 14 | Inhibition of estrogen - me- diated mammary tumorigenesis by blueberry and black raspberry 显示文摘 | Ravoori S Vadhanam M Aqil F | 2012 | J Agric Food Chem2012，60，22： | 1 |
| 15 | Advanced drug delivery systems of curcumin for cancer chemoprevention显示文摘 | Bansal SS Goel M Aqil F | 2011 | Cancer Prev Res(Phila)2011，4，8： | 1 |
| 16 | Formulation and optimization of nanotransfersomes using experimental design technique for accentuated transdermaldelivery of valsartan 显示文摘 | Ahad A Aqil M Kohli K | 2012 | Nanomed : Nanotechnol Biol Med2012，8，2： | 1 |
| 17 | Liposomal drug delivery systems : an update review 显示文摘 | SAMAD A SULTANA Y AQIL M | 2007 | Curr Drug Deliv2007，4，4： | 1 |
| 18 | Status of terpenes as skin penetration enhancers 显示文摘 | Aqil M Ahad A Sultana Y | 2007 | Drug Discov Today2007，12，2324： | 1 |
| 19 | Liposomal Drug Delivery Systems:An Update Review显示文摘 | SAMAD A SULTANA Y AQIL M | 2007 | Curr Drug Deliv2007，4，4： | 1 |
| 20 | Development of chitosan nanofibrillar scaffold for skin repair and regeneration 显示文摘 | Tchemtchoua VT Atanasova G Aqil A | 2011 | Biomacromolecules2011，12，9： | 1 |
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