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| 1 | Plecanatide-mediated activation of guanylate cyclase-C suppresses inflammation-induced colorectal carcinogenesis in Apc+/Min-FCCC mice显示文摘AIM To evaluate the effect of orally administered plecanatide on colorectal dysplasia in Apc^(+/Min-FCCC) mice with dextran sodium sulfate(DSS)-induced inflammation. METHODS Inflammation driven colorectal carcinogenesis was induced in Apc^(+/Min-FCCC) mice by administering DSS in their drinking water. Mice were fed a diet supplemented with plecanatide(0-20 ppm) and its effect on the multiplicity of histopathologically confirmed polypoid,flat and indeterminate dysplasia was evaluated. Plecanatide-mediated activation of guanylate cyclase-C(GC-C) signaling was assessed in colon tissues by measuring cyclic guanosine monophosphate(cG MP) by ELISA, protein kinase G-II and vasodilator stimulated phosphoprotein by immunoblotting. Ki-67, c-myc and cyclin D1 were used as markers of proliferation. Cellular levels and localization of b-catenin in colon tissues were assessed by immunoblotting and immunohistochemistry, respectively. Uroguanylin(UG) and GC-C transcript levels were measured by quantitative reverse transcription polymerase chain reaction(RT-PCR). A mouse cytokine array panel was used to detect cytokines in the supernatant of colon explant cultures. RESULTS Oral treatment of Apc^(+/Min-FCCC) mice with plecanatide produced a statistically significant reduction in the formation of inflammation-driven polypoid, flat and indeterminate dysplasias. This anti-carcinogenic activity of plecanatide was accompanied by activation of cG MP/GC-C signaling mediated inhibition of Wnt/b-catenin signaling and reduced proliferation. Plecanatide also decreased secretion of pro-inflammatory cytokines(IL-6, IL-1 TNF), chemokines(MIP-1, IP-10) and growth factors(GCSF and GMCSF) from colon explants derived from mice with acute DSS-induced inflammation. The effect of plecanatidemediated inhibition of inflammation/dysplasia on endogenous expression of UG and GC-C transcripts was measured in intestinal tissues. Although GC-C expression was not altered appreciably, a statistically significant increase in the level of UG transcripts was detected in the proximal small intestine and colon, potentially due to a reduction in intestinal inflammation and/or neoplasia. Taken together, these results suggest that reductions in endogenous UG, accompanied by dysregulation in GC-C signaling, may be an early event in inflammation-promoted colorectal neoplasia; an event that can potentially be ameliorated by prophylactic intervention with plecanatide.CONCLUSION This study provides the first evidence that orally administered plecanatide reduces the multiplicity of inflammation-driven colonic dysplasia in mice, demonstrating the utility for developing GC-C agonists as chemopreventive agents. | Wen-Chi L Chang Shet Masih Anusha Thadi Viren Patwa Apoorva Joshi Harry S Cooper Vaseem A Palejwala Margie L Clapper Kunwar Shailubhai | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 5 |
| 2 | Autolysis-assisted production of fish protein hydrolysates with antioxidant properties from Pacific hake (Merlucciusproductus)显示文摘 | ANUSHA G P S EUNICE C Y L | 2008 | Food Chem2008，107，： | 1 |
| 3 | Effect of Substrate Temperature on the Growth of ITO Thin Films显示文摘 | Nisha M Anusha S Antony A | 2005 | Applied Surface Science2005，252，14： | 1 |
| 4 | Pediatric nephrology patients are overweight: 20 years’ experience in a single Canadian tertiary pediatric nephrology clinic显示文摘 | Guido Filler Sílvia Mansur Reim?o Anusha Kathiravelu Joanne Grimmer Janusz Feber Alfred Drukker | 2007 | International Urology and Nephrology2007，，4： | 1 |
| 5 | A molecular receptor targeted, hydroxyapatite nanocrystal based muhimodal contrast agent显示文摘 | Anusha A Menon D Nair S | 2013 | Biomaterials2013，31，9： | 1 |
| 6 | Stability-indicating liquid chromatographic method for the determination of bendamustine hydrochloride in parenterals显示文摘 | Mathrusri AM Venkatesh B Anusha S | 2012 | Res J Chem Sci2012，2，9： | 1 |
| 7 | Effect of substrate temperature on the growth of ITO thin films显示文摘 | Nisha M Anusha S Aldrin Antony | 2005 | Applied Surface Science2005，252，： | 1 |
| 8 | Effect of substrate temperature on the growth of ITO thin films 显示文摘 | Nisha M Anusha S Antony A | 2005 | Applied Surface Science2005，，14： | 1 |
| 9 | Effect of substratetemperature on the growth of ITO thin films显示文摘 | Nisha M Anusha S Antony A | 2005 | AppliedSurface Science2005，252，5： | 1 |
| 10 | Noninvasive intracranial compliance and pressure based on dynamic magnetic resonance imaging of blood flow and cerebrospinal fluid flow: review of principle, implementation, and other noninvasive approaches 显示文摘 | Patricia BR Noam A Anusha S et aI | 2003 | J Neurosurg Focus2003，14，4： | 1 |
| 11 | Effect of substrate temperature on the growth of ITO thin films 显示文摘 | NISHA M ANUSHA S ANTONY A | 2005 | Applied Surface Science2005，252，14： | 1 |
| 12 | Improving the trust and adversary detection process for delay-tolerant networks显示文摘 | ANUSHA T RAO N S | 2013 | International Journal of Com- puter Science and Mobile Applications2013，1，5： | 1 |
| 13 | Effect of substrate temperature on the growth of ITO thin films显示文摘 | Nisha M Anusha S Antony A | 2005 | Appl Surf Sci2005，252，5： | 1 |
| 14 | Biodecolorization and biodegradation of Reactive Blue by Aspergillus sp显示文摘 | Ramya M Anusha B Kalavathy S | | 0，，12： | 1 |
| 15 | Degree associated edge reconstruction number 显示文摘 | Monikandan S Anusha Devi P Sundar Raj S | 2012 | Combinatorial Algorithms2012，7643，3： | 1 |
| 16 | Degree associated edge reconstruction number of graphs 显示文摘 | Monikandan S Anusha Devi P Sundar Raj S | 2013 | J Discrete Algorithms2013，23，2： | 1 |
| 17 | Refined families of Dothideomycetes:orders and families incertae sedis in Dothideomycetes显示文摘Numerous new taxa and classifications of Dothideomycetes have been published following the last monograph of families of Dothideomycetes in 2013.A recent publication by Honsanan et al.in 2020 expanded information of families in Dothideo-mycetidae and Pleosporomycetidae with modern classifications.In this paper,we provide a refined updated document on orders and families incertae sedis of Dothideomycetes.Each family is provided with an updated description,notes,including figures to represent the morphology,a list of accepted genera,and economic and ecological significances.We also provide phylogenetic trees for each order.In this study,31 orders which consist 50 families are assigned as orders incertae sedis in Dothideomycetes,and 41 families are treated as families incertae sedis due to lack of molecular or morphological evidence.The new order,Catinellales,and four new families,Catinellaceae,Morenoinaceae Neobuelliellaceae and Thyrinulaceae are introduced.Seven genera(Neobuelliella,Pseudomicrothyrium,Flagellostrigula,Swinscowia,Macroconstrictolumina,Pseudobogoriella,and Schummia)are introduced.Seven new species(Acrospermum urticae,Bogoriella complexoluminata,Dothiorella ostryae,Dyfrolomyces distoseptatus,Macroconstrictolumina megalateralis,Patellaria microspora,and Pseu-domicrothyrium thailandicum)are introduced base on morphology and phylogeny,together with two new records/reports and five new collections from different families.Ninety new combinations are also provided in this paper. | Sinang Hongsanan Kevin D.Hyde Rungtiwa Phookamsak Dhanushka N.Wanasinghe Eric H.C.McKenzie V.Venkateswara Sarma Robert Lücking Saranyaphat Boonmee Jayarama D.Bhat Ning-Guo Liu Danushka S.Tennakoon Dhandevi Pem Anuruddha Karunarathna Shu-Hua Jiang Gareth E.B.Jones Alan J.L.Phillips Ishara S.Manawasinghe Saowaluck Tibpromma Subashini C.Jayasiri Diana Sandamali Ruvishika S.Jayawardena Nalin N.Wijayawardene Anusha H.Ekanayaka Rajesh Jeewon Yong-Zhong Lu Chayanard Phukhamsakda Asha J.Dissanayake Xiang-Yu Zeng Zong-Long Luo Qing Tian Kasun M.Thambugala Dongqin Dai Milan C.Samarakoon K.W.Thilini Chethana Damien Ertz Mingkwan Doilom Jian-Kui(Jack)Liu Sergio Pérez-Ortega Ave Suija Chanokned Senwanna Subodini N.Wijesinghe Mekala Niranjan Sheng-Nan Zhang Hiran A.Ariyawansa Hong-Bo Jiang Jin-Feng Zhang Chada Norphanphoun Nimali Ide Silva Vinodhini Thiyagaraja Huang Zhang Jadson D.P.Bezerra Ricardo Miranda-González AndréAptroot Hiroyuki Kashiwadani Dulanjalee Harishchandra Emmanuël Sérusiaux Pranami DAbeywickrama Dan-Feng Bao Bandarupalli Devadatha Hai-Xia Wu Kwang Hee Moon Cecile Gueidan Felix Schumm Digvijayini Bundhun Ausana Mapook Jutamart Monkai Chitrabhanu S.Bhunjun Putarak Chomnunti Satinee Suetrong Napalai Chaiwan Monika C.Dayarathne Jing Yang Achala R.Rathnayaka Jian-Chu Xu Jiesheng Zheng Gang Liu Yao Feng Ning Xie | 2020 | Fungal Diversity2020，，6： | 1 |
| 18 | Effect of substrate temperature on the growth of ITO thin films 显示文摘 | NISHA M ANUSHA S ANTONY A | 2005 | Applied Surface Science2005，252，5： | 1 |
| 19 | Degree associated edge reconstruction number显示文摘 | Monikandan S Anusha Devi P Sundar Raj S | 2012 | Combinatorial Algorithms2012，7643，3： | 1 |
| 20 | Degree associated edge reconstruction number of graphs显示文摘 | Monikandan S Anusha Devi P Sundar Raj S | 2013 | Journal of Discrete Al- gorithms2013，23，2： | 1 |
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