|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Spectrum of anemia associated with chronic liver disease显示文摘Anemia of diverse etiology is a common complication of chronic liver diseases. The causes of anemia include acute or chronic gastrointestinal hemorrhage, and hypersplenism secondary to portal hypertension. Severe hepatocellular disease predisposes to hemorrhage because of impaired blood coagulation caused by deficiency of blood coagulation factors synthesized by hepatocytes, and/or thrombocytopenia. Aplastic anemia, which is characterized by pancytopenia and hypocellular bone marrow, may follow the development of hepatitis. Its presentation includes progressive anemia and hemorrhagic manifestations. Hematological complications of combination therapy for chronic viral hepatitis include clinically signif icant anemia, secondary to treatment with ribavirin and/or interferon. Ribavirininduced hemolysis can be reversed by reducing the dose of the drug or discontinuing it altogether. Interferons may contribute to anemia by inducing bone marrow suppression. Alcohol ingestion is implicated in the pathogenesis of chronic liver disease and may contribute to associated anemia. In patients with chronic liver disease, anemia may be exacerbated by defi ciency of folic acid and/or vitamin B12 that can occur secondary to inadequate dietary intake or malabsorption. | Rosario Gonzalez-Casas E Anthony Jones Ricardo Moreno-Otero | 2009 | World Journal of Gastroenterology2009，15，37： | 13 |
| 2 | Liver disease and erythropoietic protoporphyria:A concise review显示文摘The porphyries are a group of metabolic disorders characterized by deficiencies in the activity of enzymes involved in the biosynthesis of heme.In erythropoietic protoporphyria(EPP),in the majority of cases an autosomal dominant disease,there is a mutation of the gene that encodes ferrochelatase(FECH).FECH deficiency is associated with increased concentrations of protoporphyrin in erythrocytes,plasma,skin and liver.The prevalence of this inherited disorder oscillates between 1:75 000 and 1:200 000.Clinical manifestations of EPP appear in early infancy upon first exposure to the sun.Nevertheless,approximately 5%-20% of patients with EPP develop liver manifestations.Retention of protoporphyrin in the liver is associated with cholestatic phenomena and oxidative stress that predisposes to hepatobiliary disease of varying degrees of severity,such as cholelithiasis,mild parenchymal liver disease,progressive hepatocellular disease with end-stage liver disease and acute liver failure.Liver damage is the major risk in EPP patients,so surveillance and frequent clinical and biochemical liver follow-up is mandatory.The diagnostic approach consists in detecting increased levels of protoporphyrin,decreased activity of FECH and genetic analysis of the FECH gene.A variety of nonsurgical therapeutic approaches have been adopted for the management of EPP associated with liver disease,but none of these has been shown to be unequivocally efficacious.Nevertheless,some may have a place in preparing patients for liver transplantation.Liver transplantation does not correct the constitutional deficiency of FECH.Consequently,there is a risk of recurrence of liver disease after liver transplantation as a result of continuing overproduction of protoporphyrin.Some authors recommend that bone marrow transplantation should be considered in liver allograft recipients to prevent recurrence of hepatic disease. | María José Casanova-González María Trapero-Marugán E Anthony Jones Ricardo Moreno-Otero | 2010 | World Journal of Gastroenterology2010，16，36： | 7 |
| 3 | Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the CpG island methylator phenotype显示文摘AIM To identify whether Cp G island methylator phenotype(CIMP) is predictive of response to neoadjuvant chemoradiotherapy(NACRT) and outcomes in rectal cancer.METHODS Patients undergoing NACRT and surgical resection for rectal cancer in a tertiary referral centre between 2002-2011 were identified. Pre-treatment tumour biopsies were analysed for CIMP status(high, intermediate or low) using methylation specific PCR. KRAS and BRAF status were also determined using pyrosequencing analysis. Clinical information was extracted from case records and cancer services databases. Response to radiotherapy was measured by tumour regression scores determined uponhistological examination of the resected specimen. The relationship between these molecular features, response to NACRT and oncological outcomes were analysed.RESULTS There were 160 patients analysed with a median followup time of 46.4 mo. Twenty-one(13%) patients demonstrated high levels of CIMP methylation(CIMP-H) and this was significantly associated with increased risk of extramural vascular invasion(EMVI) compared with CIMP-L [8/21(38%) vs 15/99(15%), P = 0.028]. CIMP status was not related to tumour regression after radiotherapy or survival, however EMVI was significantly associated with adverse survival(P < 0.001). Intermediate CIMP status was significantly associated with KRAS mutation(P = 0.01). There were 14(9%) patients with a pathological complete response(pC R) compared to 116(73%) patients having no or minimal regression after neoadjuvant chemoradiotherapy. Those patients with pC R had median survival of 106 mo compared to 65.8 mo with minimal regression, although this was not statistically significant(P = 0.26). Binary logistic regression analysis of the relationship between EMVI and other prognostic features revealed, EMVI positivity was associated with poor overall survival, advanced 'T' stage and CIMP-H but not nodal status, age, sex, KRAS mutation status and presence of local or systemic recurrence.CONCLUSION We report a novel association of pre-treatment characterisation of CIMP-H with EMVI status which has prognostic implications and is not readily detectable on pre-treatment histological examination. | Jeremy Stuart Williamson Huw Geraint Jones Namor Williams Anthony Paul Griffiths Gareth Jenkins John Beynon Dean Anthony Harris | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 4 |
| 4 | Sources of sedimentary lipids deduced from stable carbon isotope analyses of individual compounds 显示文摘 | Gareth Rieley Robert J Collier David M Jones Geoffrey Eglinton Paul A Eakin Anthony E Fallick | 1991 | Nature1991，352，： | 1 |
| 5 | Nursing practice models:implications for information system design显示文摘 | Brennan PF Anthony M Jones J | 1998 | J Nurs Adm1998，28，10： | 1 |
| 6 | Resistant Hypertension: Diagnosis, Evaluation, and Treatment: A Scientific Statement From the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research显示文摘 | David A. Calhoun Daniel Jones Stephen Textor David C. Goff Timothy P. Murphy Robert D. Toto Anthony White William C. Cushman William White Domenic Sica Keith Ferdinand Thomas D. Giles Bonita Falkner Robert M. Carey | 2008 | Hypertension2008，，6： | 1 |
| 7 | A duplex RT-PCR assay for detection of genome segment 7 (VP7 gene) from 24 BTV serotypes 显示文摘 | Anthony S Jones H Darpel K E | 2007 | J Virol Methods2007，141，： | 1 |
| 8 | Resistant Hypertension: Diagnosis, Evaluation, and Treatment: A Scientific Statement From the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research显示文摘 | David A. Calhoun Daniel Jones Stephen Textor David C. Goff Timothy P. Murphy Robert D. Toto Anthony White William C. Cushman William White Domenic Sica Keith Ferdinand Thomas D. Giles Bonita Falkner Robert M. Carey | 2008 | Hypertension2008，，6： | 1 |
| 9 | Influence of dietary cobalt on fecal vitamin B12 and blood composition in lambs显示文摘 | JONES O H JR ANTHONY W B | 1970 | Jour- nal of Animal Science1970，31，2： | 1 |
| 10 | Electrochemical studies of group 3 alkyl derivatives: part 1 synthesis of trimethyl gallium adducts显示文摘 | Anthony Jones David Cole | 1983 | Journal of chemical industry1983，56，2： | 1 |
| 11 | The correlation of pore morphology, interconnectivity and physical properties of 3D ceramic scaffolds with bone ingrowth显示文摘 | Anthony C. Jones Christoph H. Arns Dietmar W. Hutmacher Bruce K.Milthorpe Adrian P.Sheppard Mark A.Knackstedt | | 0，，07： | 1 |
| 12 | Recent developments in the MOCVD and ALD of rare earth oxides and silicates显示文摘 | Anthony C. Jones Helen C. Aspinall Paul R. Chalker Richard J. Potter Kaupo Kukli Antti Rahtu Mikko Ritala Markku Leskel? | 2005 | Materials Science & Engineering B2005，，1： | 1 |
| 13 | Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells显示文摘 | Li Hewang Armando Ines Yu Peiying Escano Crisanto Mueller Susette C Asico Laureano Pascua Annabelle Lu Quansheng Wang Xiaoyan Villar Van Anthony M Jones John E Wang Zheng Periasamy Ammasi Lau Yuen-Sum Soares-da-Silva Patricio Creswell Kare | 2008 | Journal of Clinical Investigation2008，，6： | 1 |
| 14 | Carcinoid tumour显示文摘 | Martyn E Caplin John R Buscombe Andrew J Hilson Alison L Jones Anthony F Watkinson Andrew K Burroughs | 1998 | The Lancet1998，，9130： | 1 |
| 15 | Real-time Three-dimensional Echocardiography for Determining Right Ventricular Stroke Volume in an Animal Model of Chronic Right Ventricular Volume Overload显示文摘 | Takahiro Shiota Michael Jones Masahide Chikada Craig E. Fleishman John B. Castellucci Bruno Cotter Anthony N. DeMaria Olaf T. von Ramm Joseph Kisslo Thomas Ryan David J. Sahn | 1998 | Circulation1998，，19： | 1 |
| 16 | REPRINT Resistant Hypertension: Diagnosis, Evaluation, and Treatment: A Scientific Statement From the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research显示文摘 | David A. Calhoun Daniel Jones Stephen Textor David C. Goff Timothy P. Murphy Robert D. Toto Anthony White William C. Cushman William White Domenic Sica Keith Ferdinand Thomas D. Giles Bonita Falkner Robert M. Carey | 2008 | Circulation2008，，25： | 1 |
| 17 | REPRINT Resistant Hypertension: Diagnosis, Evaluation, and Treatment: A Scientific Statement From the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research显示文摘 | David A. Calhoun Daniel Jones Stephen Textor David C. Goff Timothy P. Murphy Robert D. Toto Anthony White William C. Cushman William White Domenic Sica Keith Ferdinand Thomas D. Giles Bonita Falkner Robert M. Carey | 2008 | Circulation2008，，25： | 1 |
| 18 | An evaluation of varying protocols for high‐level disinfection of flexible fiberoptic laryngoscopes显示文摘 | Bryan Liming Ian Funnell Anthony Jones Samandra Demons Kathryn Marshall Wayne Harsha | 2014 | The Laryngoscope2014，，： | 1 |
| 19 | Droplet impact and spreading:Droplet formulation effects显示文摘 | Stephen R L Werner Jim R Jones Anthony H J | 2007 | Chemical Engineering Engineering Science2007，62，9： | 1 |
| 20 | 气相色谱三重四极杆气质联用系统分析水样中的N-亚硝基二甲胺显示文摘本文使用Agilent 7890A系列气相色谱仪与Agilent 7000B三重四极杆气质联用系统以正化学电离(PCI)模式开发了灵敏度可达ng·L^(-1)或更低的N-亚硝基二甲胺(NDMA)的分析方法.该方法还为需要采用常规离子阱质谱法分析但又没有离子阱仪器的实验室提供了一种可行的替代方案,方法的检测限(LOD)达0.20 ng·L^(-1),定量限(LOQ)达0.56 ng·L^(-1). | Alandra Kahl Darryl Jones Lisa Lowe Shane Snyder Anthony Macherone | 2016 | 环境化学2016，35，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员