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| 1 | Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria显示文摘AIM: To investigate the correlation between in vitro and in vivo immunomodulation potential of the probiotic strain and its ability to prevent experimental colitis in mice. METHODS: In vitro immunomodulation was assessed by measuring interleukin (IL)-12p70, IL-10, tumor necrosis factor alpha (TNFa) and interferon g (IFNg) release by human peripheral blood mononuclear cells (PBMCs) after 24 h stimulation with 13 live bacterial strains. A murine model of acute TNBS-colitis was next used to evaluate the prophylactic protective capacity of the same set of strains. RESULTS: A strain-specific in vivo protection was observed. The strains displaying an in vitro potential to induce higher levels of the anti-inflammatory cytokine IL-10 and lower levels of the inflammatory cytokine IL-12, offered the best protection in the in vivo colitis model. In contrast, strains leading to a low IL-10/IL-12 cytokine ratio could not significantly attenuate colitis symptoms. CONCLUSION: These results show that we could predict the in vivo protective capacity of the studied lactic acid bacteria (LAB) based on the cytokine profile we established in vitro. The PBMC-based assay we used may thus serve as a useful primary indicator to narrow down the number of candidate strains to be tested inmurine models for their anti-inflammatory potential. | Benoit Foligne Sophie Nutten Corinne Grangette Véronique Dennin Denise Goudercourt Sabine Poiret Joelle Dewulf Dominique Brassart Annick Mercenier Bruno Pot | 2007 | World Journal of Gastroenterology2007，13，2： | 22 |
| 2 | Ribavirin:Past,present and future显示文摘Before the advent of direct acting antiviral agents(DAAs) ribavirin, associated to pegylated-interferon played a crucial role in the treatment of chronic hepatitis C, preventing relapses and breakthroughs. In the present era of new potent DAAs, a place is still devoted to the drug. Ribavirin associated with sofosbuvir alone is efficient in the treatment of most cases of G2 infected patients. All options currently available for the last difficult-to-treat cirrhotic G3 patients contain ribavirin. Reducing treatment duration to 12 wk in G1 or G4 cirrhotic compensated patients is feasible thanks to ribavirin. Retreating patients with acquired anti NS5 A resistance-associated variants using ribavirin-based strategies could be useful. The addition of ribavirin with DAAs combinations however, leads to more frequent but mild adverse events especially in cirrhotic patients. Preliminary data with interferon-free second generation DAAs combinations without ribavirin suggest that future of the drug is jeopardized even in difficult-totreat patients: The optimization of ribavirin dosage according to an early monitoring of blood levels has been suggested to be relevant in double therapy with peginterferon or sofosbuvir but not with very potent combinations of more than two DAAs. | Véronique Loustaud-Ratti Marilyne Debette-Gratien Jérémie Jacques Sophie Alain Pierre Marquet DenisSautereau Annick Rousseau Paul Carrier | 2016 | World Journal of Hepatology2016，8，2： | 3 |
| 3 | Residual alkalinity as tracer to estimate the changes indueed by forage cultivation in a non-saline irrigated sodic soil显示文摘 | Laurent B Vincent V Annick R | 2001 | Agricultural Water Management2001，50，3： | 1 |
| 4 | Functional conservation between CRABS CLAW orthologues from widely diverged angiosperms显示文摘 | CHLOE F MARION V D PIERRE C ANNICK B D CHARLES P SCUTT | 2007 | Annals of Botany2007，100，： | 1 |
| 5 | The NK1-receptor an- tagonist NKP 608 has an antidepressant-like effect in the chronic mild stress model of depression in rats 显示文摘 | MARIUSZ P ANNICK V CONRAD G | 2000 | Behav Brain Res2000，115，1： | 1 |
| 6 | Physicochemical characterization and oxidative stability of fish oil encapsulated in an amorphous matrix containing trehalose显示文摘 | STEPHAN D YVONNE S ANNICK V D H | 2006 | Food Research International2006，39，： | 1 |
| 7 | Physicochemical characterization and oxidative stability of fish oil encapsulated in an amorphous matrix containing trehalose显示文摘 | STEPHAN D YVONNE S ANNICK V D H | 2006 | Food Research International2006，39，： | 1 |
| 8 | Physicochem-ieal char- acterization and oxidative stability of fish oil encap-sulated in an amorphousmatrix containing trehalose显示文摘 | Stephan D Yvonne S Annick V D H | 2006 | Food research intermation- al2006，39，7： | 1 |
| 9 | Physicochem-ical char- acterization and oxidative stability of fish oil encap-sulated in an amorphousmatrix containing trehalose显示文摘 | Stephan D Yvonne S Annick V D H | 2006 | Food research intermation- al2006，39，7： | 1 |
| 10 | Direct observation of intense turbidity current activity in the Zaire submarine valley at 4 000 m water depth显示文摘 | Alexis K Annick V Nathalie B | 2003 | Marine Geology2003，194，34： | 1 |
| 11 | Thrombocytopenia and prognosis in intensive care显示文摘 | Steven V Annick DW Manu M | 2000 | Crit Care Med2000，28，6： | 1 |
| 12 | Physiochemical characterization and oxidative stability of fish oil encapsulated in an amorphous matrix containing trehalose 显示文摘 | Stephan D Yvonne S Annick V D | 2006 | Food Research International2006，39，： | 1 |
| 13 | A group 3 lea cDNA of rice,responsive to abscisic acid,but not to jasmonic acid,shows variety-specific differences in salt stress response显示文摘 | Ann M Annick D K Marc V M | 1997 | Gene1997，191，： | 1 |
| 14 | The American Balanced Scorecard Versus the French Tableau de Bord:the Ideological Dimension显示文摘 | Annick Bourguignon V e ronique Malleret Hanne Norreklit | 2004 | Accounting Research2004，，15： | 1 |
| 15 | Anti-hepatitis C virus drugs and kidney显示文摘Hepatitis C virus(HCV) mainly targets the liver but can also induce extrahepatic manifestations. The kidney may be impacted via an immune mediated mechanism or a cytopathic effect. HCV patients are clearly at a greater risk of chronic kidney disease(CKD) than uninfected patients are, and the presence of CKD increases mortality. Interferon-based therapies and ribavirin are difficult to manage and are poorly effective in endstage renal disease and hemodialysis. These patients should be given priority treatment with new direct anti-viral agents(DAAs) while avoiding peginterferon and ribavirin. The first results were convincing. To aid in the correct use of these drugs in patients with renal insufficiency, their pharmacokinetic properties and potential renal toxicity must be known. The renal toxicity of these new drugs was not a safety signal in clinical trials, and the drugs are generally efficient in these frail populations. These drugs are usually well tolerated, but recent cohort studies have demonstrated that these new regimens may be associated with renal side effects, especially when using sofosbuvir combinations. HCV, renal diseases and comorbidities are intimately linked. The close monitoring of renal function is required, particularly for at-risk patients(transplanted, HIV-coinfected, CKD, hypertensive or diabetic patients). New DAA regimens, which will soon be approved, will probably change the landscape. | Paul Carrier Marie Essig Marilyne Debette-Gratien Denis Sautereau Annick Rousseau Pierre Marquet Jérémie Jacques Véronique Loustaud-Ratti | 2016 | World Journal of Hepatology2016，8，32： | 0 |
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