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您的检索式：作者名="Anne Petzold"
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| 1 | Xerotolerant foliar endophytic fungi of Populus euphratica from the Tarim River basin,Central China are conspecific to endophytic ITS phylotypes of Populus tremula from temperate Europe显示文摘Fungal research on non-lichenized taxa in xeric and other unusual habitats for fungi is comparatively scarce but constantly reveal an enormous ecological and functional adaptiveness of these organisms to extremes.This holds true in the topmost forest canopies as well as in marine,arctic,antarctic or desert habitats.In the present study dried leaves of Populus euphratica from a continental desert area in Central China were investigated for endophytic fungi 6 weeks after sampling by cultivation of small leaf fragments.Thirty-five species,many of them well-known from extreme environments,were delimitated from as few as 58 isolates by a combined analysis of morphotypes,micromorphology and ITS sequences.Meta-analyses revealed pronounced conspecificity to endophytes from Populus tremula leaves,but significant differences to foliar endophytic assemblages in Pinus monticola and Fagus sylvatica.The deduced high similarity of endophytic communities on both Populus species compared with that on Pinus and Fagus suggests that many fungal phyllosphere species show a well-pronounced host preference,at least for their endophytic stages.In addition,it demonstrates that leaving leaves as a microhabitat might provide similar conditions such as constantly high relative humidity,regardless of the surrounding climatic conditions.The evolution of extremotolerance might be of particular importance for retaining competitiveness of foliar endophytes in deciduous host trees after loss of pathogenicity. | Martin Unterseher Anne Petzold Martin Schnittler | 2012 | Fungal Diversity2012，，3： | 1 |
| 2 | Liver-directed treatment is associated with improved survival and increased response to immune checkpoint blockade in metastatic uveal melanoma:results from a retrospective multicenter trial显示文摘Metastases of uveal melanoma(UM)spread predominantly to the liver.Due to low response rates to systemic therapies,liver-directed therapies(LDT)are commonly used for tumor control.The impact of LDT on the response to systemic treatment is unknown.A total of 182 patients with metastatic UM treated with immune checkpoint blockade(ICB)were included in this analysis.Patients were recruited from prospective skin cancer centers and the German national skin cancer registry(ADOReg)of the German Dermatologic Cooperative Oncology Group(DeCOG).Two cohorts were compared:patients with LDT(cohort A,n=78)versus those without LDT(cohort B,n=104).Data were analyzed for response to treatment,progression-free survival(PFS),and overall survival(OS).The median OS was significantly longer in cohort A than in cohort B(20.1 vs.13.8 months;P=0.0016)and a trend towards improved PFS was observed for cohort A(3.0 vs.2.5 months;P=0.054).The objective response rate to any ICB(16.7%vs.3.8%,P=0.0073)and combined ICB(14.1%vs.4.5%,P=0.017)was more favorable in cohort A.Our data suggest that the combination of LDT with ICB may be associated with a survival benefit and higher treatment response to ICB in patients with metastatic UM. | Elias A.T.Koch Anne Petzold Anja Wessely Edgar Dippel Markus Eckstein Anja Gesierich Ralf Gutzmer Jessica C.Hassel Harald Knorr Nicole Kreuzberg Ulrike Leiter Carmen Loquai Friedegund Meier Markus Meissner Peter Mohr Claudia Pföhler Farnaz Rahimi Dirk Schadendorf Max Schlaak Kai-Martin Thoms Selma Ugurel Jochen Utikal Michael Weichenthal Beatrice Schuler-Thurner Carola Berking Markus V.Heppt | 2023 | Frontiers of Medicine2023，17，5： | 0 |
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