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| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | 粉煤灰和砂壤土混合后水力学特征参数的试验研究显示文摘将粉煤灰与砂壤土按体积比1∶2混合后,进行混合物水分特征曲线和渗透系数等水力学特征参数的试验研究,结果表明:两种粉煤灰与砂壤土混合后,均能提升砂壤土的饱和含水量、田间含水量,以及植物有效水含量。因粉煤灰的颗粒组成差异,混合物水分特征曲线在pF值小于1.8时,其形态可能会向上或向下修正。但当pF值大于1.8时,无论粉煤灰的颗粒组成,同一基质吸力的混合物体积含水量均大于砂壤土。当基质含水量较高时,粗颗粒粉煤灰与砂壤土混合物的非饱和渗透系数下降速率较快。研究结果为粉煤灰充填复垦或粉煤灰场覆土复垦地田间水分管理提供理论基础。 | 陈孝杨 严家平 Rudiger Anlauf | 2012 | 煤炭工程2012，44，9： | 5 |
| 3 | 德国应用型高等教育面面观显示文摘应用型教育是德国高等院校,尤其是应用型大学的人才培养重点之一。基于学生的教育和实践背景、师资需求、学生的实践入学资格等方面介绍德国不同类型大学在应用型教育上的差别;其次介绍应用型教育的范例,如:实践类课程、项目教学、课程实习和与私营企业合作完成的论文。最后,提出实施应用型教育的措施,如开展应用型研究;设立包括具备职业经验的代表在内的学习项目咨询委员会,为课程设置和课程内容提出建议;建立职业中心,为学生提供职业规划指导。 | Ruediger Anlauf 李静 金玉 陈颖 | 2016 | 应用型高等教育研究2016，1，1： | 5 |
| 4 | Hyperinsulinemic hypoglycemia due to adult nesidioblastosis in insulin-dependent diabetes显示文摘In neonates, persistent hyperinsulinemic hypoglycemia (PHH) is associated with nesidioblastosis. In adults, PHH is usually caused by solitary benign insulinomas. We report on an adult patient who suffered from insulin-de- pendent diabetes mellitus, and subsequently developed PHH caused by diffuse nesidioblastosis. Mutations of the MEN1 and Mody 2/3 genes were ruled out. Preoperative diagnostic procedures, the histopathological criteria and the surgical treatment options of adult nesidioblastosis are discussed. So far only one similar case of adult nesidioblastosis subsequent to diabetes mellitus Ⅱ has been reported in the literature. In case of conversion of diabetes into hyperinsulinemic hypoglycemia syndrome, nesidioblastosis in addition to insulinoma should be con- sidered. | A Raffel M Anlauf SB Hosch M Krausch T Henopp J Bauersfeld R Klofat D Bach CF Eisenberger G Klppel WT Knoefel | 2006 | World Journal of Gastroenterology2006，12，44： | 3 |
| 5 | ENETS Consensus Guidelines for the Management of Patients with Liver and Other Distant Metastases from Neuroendocrine Neoplasms of Foregut, Midgut, Hindgut, and Unknown Primary显示文摘 | Pavel Marianne Baudin Eric Couvelard Anne Krenning Eric ?berg Kjell Steinmüller Thomas Anlauf Martin Wiedenmann Bertram Salazar Ramon | 2012 | Neuroendocrinology2012，，2： | 3 |
| 6 | Determination of the energy consumption during the production of various concrete recipes显示文摘 | DAUMANN B ANLAUF H NIRSCHL H | 2009 | Cement and Concrete Research2009，39，7： | 1 |
| 7 | Epidemiology,tumour biology and his-topathological classification of neuroendocrine tumours of thegastrointestinal tract显示文摘 | Kloppel G Anlauf M | 2005 | Best Pract Res Clin Gastroenterol2005，19，4： | 1 |
| 8 | Localization of xenin-im- munoreactive cells in the duodenal mucosa of human and various mammals 显示文摘 | Anlauf M Weihe E Hartschuh W | 2000 | J Histochem Cytochem2000，48，12： | 1 |
| 9 | Islet 1 (Isll) expression is a reliable marker for pancreatic endocrine :urnors and their metastases 显示文摘 | Schmitt A M Riniker F Anlauf M st al | 2008 | Am J Surg Pathol2008，32，3： | 1 |
| 10 | Recent developments in centrifuge technology显示文摘 | Anlauf H | 2007 | Separation and Purification Technology2007，58，： | 1 |
| 11 | Recent developments in centrifuge technology 显示文摘 | Harald Anlauf | 2007 | Separation and Purification Technology2007，58，： | 1 |
| 12 | A new class of organosoluble rigid-rod, fully aromatic poly (1,3, 4-oxadiazole)s and their solid-state properties显示文摘 | Janietz S Anlauf S Wedel A | 2002 | Macromol Chem Phys2002，203，： | 1 |
| 13 | Encapsulation status of papillary thyroid microcarcinomas is associated with the risk of lymph node metastases and tumor multifocality显示文摘 | Cupisti K Lehwald N Anlauf M | 2014 | Homl Metab Res2014，46，2： | 1 |
| 14 | Loss of pten expression inneuroendocrine pancreatic tumors显示文摘 | Krausch M Raffel A Anlauf M | 2011 | Horm Metab Res2011，43，12： | 1 |
| 15 | Recent developments in centrifuge technology 显示文摘 | Harald Anlauf | 2007 | Separation and Purification Technology2007，，58： | 1 |
| 16 | Endocrine Precursor Lesions of Gastroenteropancreatic Neuroendocrine Tumors显示文摘 | Günter Kl?ppel Martin Anlauf Aurel Perren | 2007 | Endocrine Pathology2007，，3： | 1 |
| 17 | Islet 1 (Isll) expression is a reliable marker for pancreatic endocrine tumors and their metastases 显示文摘 | Schmitt A M Riniker F Anlauf M | 2008 | Am J Surg Pathol2008，32，3： | 1 |
| 18 | Arctic springtime depletion of mercury 显示文摘 | Schroeder W H Anlauf K G Barrie L A | 1998 | Nature1998，394，33： | 1 |
| 19 | Recent developments in centrifuge technology显示文摘 | Harald Anlauf | 2007 | Separation and Purification Technology2007，58，： | 1 |
| 20 | Adult diffuse nesidoblastosis: genetically or environmentally induced 显示文摘 | KL'O'PPEL G ANLAUF M RAFFEL A | 2008 | Hum pathol2008，39，1： | 1 |
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