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| 1 | Neoadjuvant chemotherapy with six cycles of carbo- platin and paclitaxel in advanced ovarian cancer patients unsuitable for primary surgery:safety and effectiveness显示文摘 | da Costa Miranda V de Souza Forde hB Dos Anjos CH | 2014 | Gynecol Oncol2014，132，2： | 1 |
| 2 | Positron emission tomography with (18)F-FDG in the evaluation of patients with rheumatoid arthritis--a systematic review显示文摘 | dos Anjos DA da Mota LM | 2014 | Rev Bras Renmatol2014，54，6： | 1 |
| 3 | 18F_FDG PET/CT delayed images after diuretic for restaging invasive bladder cancer显示文摘 | Anjos DA Etchebehere EC Ramos CD | 2007 | J Nucl Med2007，48，5： | 1 |
| 4 | Far beyond the usual biomarkers in breast cancer:a review显示文摘 | Dos Anjos Pultz B da Luz FA de Faria PR | 2014 | J Cancer2014，5，7： | 1 |
| 5 | Normal values of pertechnetate uptake and excretion fraction by major salivary glands显示文摘 | Anjos DA Etchebehere EC Santos AO | 2006 | Nucl Med Commun2006，27，4： | 1 |
| 6 | ^18F-FDG PET/CT delayed images after diuretic for restaging invasive bladder cancer 显示文摘 | Anjos DA Etchebehere EC Ramos CD | 2007 | J Nucl Med2007，48，： | 1 |
| 7 | Normal values of pertechnetate uptake and excretion fraction by major salivary glands 显示文摘 | Anjos DA Etchebehere EC Santos AO | 2006 | Nucl Med Commun2006，27，4： | 1 |
| 8 | COVID-19 liver and gastroenterology findings:An in silico analysis of SARS-CoV-2 interactions with liver molecules显示文摘BACKGROUND Coronavirus disease 19(COVID-19)has not only been shown to affect the respiratory system,but has also demonstrated variable clinical presentations including gastrointestinal tract disorders.In addition,abnormalities in liver enzymes have been reported indicating hepatic injury.It is known that severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)might infect cells via the viral receptor angiotensin-converting enzyme 2(ACE2)which is expressed in several organs including the liver.The viral Spike glycoprotein binds to ACE2 and must be cleaved by Furin and Type 2 Serine Protease to enter the cells.After that,the Akt/mTOR signaling pathway is activated and several COVID-19 changes are triggered.AIM To analyze liver and gastrointestinal symptoms and cell signaling pathways triggered by SARS-CoV-2 infection due to virus-liver interactions in silico.METHODS In this in silico study,the three-dimensional structures of the Akt,mTORC1 and Furin(receptors)were selected from the Protein Data Bank(PDB)and the structures of inhibitors(ligands)MK-2206,CC-223 and Naphthofluorescein were selected from PubChem and ZINC databases.Ligand files were downloaded as 2D structures and converted to optimized 3D structures using ViewerLite 4.2 software.Marvin Sketch®software was used to calculate prediction of the protonated form of inhibitors in a physiological environment(pH 7.4).AutoDock Tools(ADT)software was used to calculate and delimit the Grid box used in the molecular docking of each structure selected in the PDB.In addition,protonated ligands were prepared for molecular docking using ADT software.Molecular docking was performed using ADT software tools connected to Vina software.Analysis of the amino acid residues involved in ligand interactions,as well as ligand twists,the atoms involved in interactions,bond type and strength of interactions were performed using PyMol^(■)and Discovery Studio^(■)(BIOVIA)software.RESULTS Molecular docking analysis showed that the mTORC1/CC-223 complex had affinity energy between the receptor and ligand of-7.7 kcal/moL with interactions ranging from 2.7 to 4.99Å.There were four significant chemical bonds which involved two of five polypeptide chains that formed the FKBP12–Rapamycin-Binding(FRB)domain.The strongest was a hydrogen bond,the only polar interaction,and Van der Waals interactions shown to be present in 12 residues of mTORC1’s FRB domain.With regard to the Akt/MK-2206 complex there were three Van der Waals interactions and 12 chemical bonds in which seven residues of Akt were involved with all five rings of the MK-2206 structure.In this way,both ASP 388 and GLN 391 bind to the same MK-2206 ring,the smaller one.However,LYS 386 had four chemical bonds with the inhibitor,one with each structure ring,while LYS 387 binds two distinct rings.One of the MK-2206 inhibitor's rings which binds to LYS 387 also binds simultaneously to ILE 367 and LEU 385 residues,and the fifth ring of the structure was involved in a bond with the ALA 382 residue.The hydrogen bonds were the shortest bonds in the complex(2.61 and 3.08Å)and all interactions had an affinity energy of-8.8 kcal/moL.The affinity energy in the Furin/Naphhofluorescein complex was-9.8 kcal/moL and involved six interactions ranging from 2.57 to 4.98Å.Among them,two were polar and the others were non-polar,in addition to twelve more Van der Waals interactions.Two distinct hydrogen bonds were formed between Furin and its inhibitor involving GLN 388 and ALA 532 residues.ALA 532 also binds to two distinct rings of Naphthofluorescein,while TRP 531 residue has two simultaneous bonds with the inhibitor.CONCLUSION Liver infection and signaling pathways altered by SARS-CoV-2 can be modulated by inhibitors that demonstrate significant interaction affinity with human proteins,which could prevent the development of infection and symptoms. | Gabrielle Caroline Peiter Cristiano de Bem Torquato de Souza Lucca Miketen de Oliveira Luis Gustavo Pagliarin Valentina Nunes Fontoura dos Anjos Filipe Antônio França da Silva Fabrício Freire de Melo Kádima Nayara Teixeira | 2022 | World Journal of Hepatology2022，14，6： | 1 |
| 9 | Extra-articular inflammatory sites detected by F-18 FDG PET/CT in a patient with rheumatoid arthritis显示文摘 | Dos Anjos DA Do Vale GF Campos Cde M | 2010 | Clin Nucl Med2010，35，7： | 1 |
| 10 | Neoadjuvant chemotherapy with six cycles of carboplatin and paclitaxel in advanced ovarian cancer patients unsuitable for primary surgery: Safety and effectiveness显示文摘 | Vanessa da Costa Miranda ?ngelo Bezerra de Souza Fêde Carlos Henrique dos Anjos Juliana Ribeiro da Silva Fernando Barbosa Sanchez Lyvia Rodrigues da Silva Bessa Jesus de Paula Carvalho Elias Abdo Filho Daniela de Freitas Maria Del Pilar Estevez Diz | 2013 | Gynecologic Oncology2013，，： | 1 |
| 11 | Neoadjuvant chemotherapy w ith six cycles of carboplatin and paclitaxel in advanced ovarian cancer patients unsuitable for primary surgery:safety and effectiveness显示文摘 | Da Costa Miranda V De Souza FêdeB Dos Anjos CH | 2014 | Gynecol Oncol2014，132，2： | 1 |
| 12 | 18F-FDG PET/CT delayed images after diuretic for restaging invasive bladder cancer显示文摘 | Anjos DA Etchebehere EC Ramos CD | 2007 | J Nucl Med2007，48，： | 1 |
| 13 | Neo- adjuvant chemotherapy with six c3cles of carboplatin and paclitaxel in advanced ovarian cancer patients unsuitable for primary surgery : Safety and effectiveness 显示文摘 | da Costa Miranda V de Souza F~de ~B Dos Anjos CH | 2014 | Gynecol Oncol2014，132，2： | 1 |
| 14 | Peptidevaccines in breast cancer: The immunological basis for clinical re-sponse 显示文摘 | de Paula Peres L da Luz FA Dos Anjos Pultz B | 2015 | Biotechnol Adv2015，33，8： | 1 |
| 15 | Occupational ex-posure to radon and natural gamma radiation in the La Caro-lina,a former gold mine in San Luis Province,Argentina显示文摘 | Anjos R M Umisedo N da Silva A A R | 2010 | Journal of Environmental Radioactivity2010，101，2： | 1 |
| 16 | 18F-FDG PET/CT Delayed Images After Diuretic for Restaging Invasive Bladder Cancer显示文摘 | Anjos DA Etehebehere EC Ramos CD | 2007 | J Nucl Med2007，48，5： | 1 |
| 17 | Normal values of pertechnetate uptake and excretion fraction by major salivary glands显示文摘 | Anjos DA Etchebehere EC Santos AO | 2006 | Nucl Med Commun2006，27，4： | 1 |
| 18 | Normal values of pertechnetate up take and excretion fraction by major salivary glands 显示文摘 | Anjos DA Etchebehere EC Santosa O | 2006 | Nucl Med Commun2006，27，4： | 1 |
| 19 | Spectrophotometric cocaine determination in a biphasic medium employing flow-batch sequential injection analysis显示文摘 | da Silva MJ dos Anjos EV Honorato RS | 2008 | Anal Chim Acta2008，629，12： | 1 |
| 20 | Extra-articu larinflamm a tory sites d etec led by F-18 FDG PET/CT in a pati ent withrheum ato id arthritis 显示文摘 | Dos Anjos DA Do Vale GF Cam pos Cde M | 2010 | Clin Nucl Meal2010，35，7： | 1 |
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