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| 1 | X-ray scintillation in lead-free double perovskite crystals显示文摘Metal halide perovskites have shown great performance for various applications,including solar cells,light emitting diodes,and radiation detectors,but they still suffer from the toxicity of lead and instability.Here we report the use of lanthanide series as trivalent metals to obtain low toxicity and highly stable double perovskites(Cs_2NaLnCl_6,Ln=Tb or Eu)with high scintillation light yield.The crystals exhibit typical f-f transitions of lanthanide cations,while Cs_2NaTbCl_6exhibits strong green photoluminescence,and Cs_2NaEuCl_6exhibits red photoluminescence.Under X-ray radiations,the light yield of Cs_2NaTbCl_6reaches46600 photons MeV^(-1),much higher than that of the commercially used(Lu,Y)_2SiO_5:Ce^(3+)crystals(LYSO,28500 photons MeV^(-1)),and previously reported lead-based perovskites(14000 photons MeV^(-1)).As a new member of lead-free perovskites,lanthanide-based double perovskites open up a new route toward radiation detections and potential medical imaging. | Qingsong Hu Zhenzhou Deng Manchen Hu Anjiang Zhao Yaqi Zhang Zhifang Tan Guangda Niu Haodi Wu Jiang Tang | 2018 | Science China Chemistry2018，61，12： | 7 |
| 2 | A CCCH zinc finger gene regulates doublesex alternative splicing and male development in Bombyx mori显示文摘Recent identification of a Piwi-interacting RNA(piRNA)-initiated sex determination cascade in the silkworm,Bombyx mori,provides novel insights into high diversity of insect sex determination pathways.In this system,the W-chromosome-derived Fem piRNA is the primary sex determination signal.A CCCH-type zinc finger gene Masculinizer(Masc),which is targeted by Fem piRNA-PIWI complex in female animals,is indispensable for male-specific splicing of B.mori doublesex(Bmdsx).Although many genes involved in this cascade have been identified,the regulatory mechanisms of silk-worm sex determination remain to be elucidated.Here we show that another CCCH-type zinc finger gene,Bmznf-2,is a masculinization factor in B.mori.Bmznf-2 shows testisabundant expression and loss of Bmznf-2 function via clustered regularly interspaced short palindromic repeats 1 single-guide RNA-mediated mutagenesis results in feminized differentiation and appearance of the female-specific splicing variants of Bmdsx transcripts in males.In contrast,there is no phenotypic consequence in mutant females.In mutant males,relative messenger RNA expression levels of female-dominant genes such as vitellogenin and sex-specific storage protein I are significantly clevated while several male-dominant genes are significantly down-regulated.Furthermore,male mutants show delayed developmental timing,smaller body sizes of larvae and malformation of moth wings.Our data thus reveal that Bmznf-2 plays an indispensable role in silkworm male sexual differentiation. | Fangying Yang Zhongjie Zhang Bo Hu Ye Yu Anjiang Tan | 2021 | Insect Science2021，28，5： | 1 |
| 3 | Two dehydroecdysone reductases act as fat body-specific 20E catalyzers in Bombyx mori显示文摘Periodic post-embryonic changes in insects, including growth, development and metamorphosis, are strictly controlled by many compounds, including steroid hormones. The biosynthesis and clearance of 20-hydroxyecdysone (20E), the major active form of the insect steroid hormone ecdysone, result in titer fluctuations that help control insect development. The inactivation of 20E in the silkworm Bombyx mori is highly tissue-specific, with CYP18A1 and ecdysone oxidase controlling 20E inactivation specifically in the mid-silk gland and midgut, respectively. Here, we characterized silkworm 3-dehydroecdysone 3α reductase (Bm3DE3α) and 3-dehydroecdysone 3β reductase (Bm3DE3β), two enzymes involved predominantly in the C-3-mediated catalysis of 20E in fat bodies. The ubiquitous and silk gland-specific overexpression of Bm3DE3α decreased the 20E titer, resulting in larval lethality and larval–pupal transition failure, respectively. In contrast, the ubiquitous and mid-silk gland-specific overexpression of Bm3DE3β increased the 20E titer, resulting in larval growth delays and lethality at the mid-fifth larval stage, respectively. Thus, Bm3DE3α and Bm3DE3β mediate fat body-specific steroid hormone metabolism in B. mori, indicating that highly diversified 20E metabolism-related mechanisms exist in different insect species. | Lang You Zhiqian Li Zhongjie Zhang Bo Hu Ye Yu Fangying Yang Anjiang Tan | 2022 | Insect Science2022，29，1： | 1 |
| 4 | Edysone receptor isoforms play distinct roles in controlling molting and metamorphosis in the red flour beetle, Tribolium castaneum显示文摘 | Anjiang Tan Subba Reddy Palli | 2008 | Molecular and Cellular Endocrinology2008，，1： | 1 |
| 5 | MicroRNA-281 regulates the expression of ecdysone receptor (EcR) isoform B in the silkworm, Bombyx mori显示文摘 | Jianhao Jiang Xie Ge Zhiqian Li Yueqiang Wang Qisheng Song David W. Stanley Anjiang Tan Yongping Huang | 2013 | Insect Biochemistry and Molecular Biology2013，，8： | 1 |
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