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| 1 | Epstein-Barr virus and Burkitt lymphoma显示文摘In 1964,a new herpesvirus,Epstein-Barr virus(EBV),was discovered in cultured tumor cells derived from a Burkitt lymphoma(BL)biopsy taken from an African patient.This was a momentous event that reinvigorated research into viruses as a possible cause of human cancers.Subsequent studies demonstrated that EBV was a potent growth-transforming agent for primary B cells,and that all cases of BL carried characteristic chromosomal translocations resulting in constitutive activation of the c-MYC oncogene.These results hinted at simple oncogenic mechanisms that would make Burkitt lymphoma paradigmatic for cancers with viral etiology.In reality,the pathogenesis of this tumor is rather complicated with regard to both the contribution of the virus and the involvement of cellular oncogenes.Here,we review the current understanding of the roles of EBV and c-MYC in the pathogenesis of BL and the implications for new therapeutic strategies to treat this lymphoma. | Martin Rowe Leah Fitzsimmons Andrew I Bell | 2014 | Chinese Journal of Cancer2014，33，12： | 14 |
| 2 | 澳大利亚临床共识指南:儿童卒中的诊断和急性期处理显示文摘卒中是导致儿童死亡的十大原因之一,幸存的致残患儿将面临几十年的残疾生活,给患儿及其家庭带来了巨大负担。由于安全性和有效性的证据有限,以及诊断的延误,目前卒中患儿无法接受再灌注治疗。儿童卒中诊断和急性期处理的澳大利亚临床共识指南,旨在最大限度地减少临床诊疗中的不确定性,并记录与成人卒中不同的危险因素、病因和假性卒中情况的最佳证据。临床问题的阐述来自于对2007年至2017年数据库的系统检索,但仅限于英语和儿科研究。该指南应用SIGN方法和国家健康与医学研究委员会系统对证据进行筛选和分类,通过推荐、评估、发展和评价系统(GRADE系统)对推荐进行强弱分级。该指南提供了60多项基于证据的推荐,以帮助参与院前和急症处理的临床医师快速识别儿童卒中,选择最合适的初步检查方案来确定诊断、明确病因,并选择最恰当的干预措施以挽救脑组织、预防复发。同时,指南也提供了颅内压和先天性心脏病管理方面的推荐。该指南的实施需要将院前和急诊系统重组,包括建立区域性卒中网络,建立儿科卒中疾病编码,快速MRI,以及对能够提供再灌注治疗的初级儿科卒中中心进行认证。该指南能够审核治疗的基准时间线,获得急性期的干预措施及预后判断。它还将促进澳大利亚儿童卒中登记的发展,并与国际登记处建立数据联系,以便准确收集卒中发病率、治疗和结果相关的数据。 | Medley TL Miteff C Andrews I Ware T Cheung M Monagle P Mandelstam S Wray A Pridmore C Troedson C Dale RC Fahey M Sinclair A Walsh P Stojanovski S Macka MT 徐佳丽(译) 吴川杰(译) 肖潇(译) 吕俊萱(译) 张博维(译) 吉训明(译) | 2019 | 中国脑血管病杂志2019，16，4： | 9 |
| 3 | 座椅热舒适性客观评价温度模型构建显示文摘本文建立了人体—座椅接触面的温度模型,利用实测温度数据验证了模型的精度。从接触面温度特性模型中提取出了三个评价指标:接触面最终温度,接触面温度的最大变化率以及接触面的平均温度,据此建立了座椅舒适度客观评价体系。利用评价体系对三种材料座椅(泡沫、压模和木质座椅)进行评估,结果表明:泡沫座椅的舒适度得分为8.96±2.58,压模座椅的舒适度得分为6.15±1.96,木质座椅的舒适度得分为4.91±1.88。主观测评法得到的座椅舒适度得分为:泡沫座椅的舒适度得分为8.36±1.21,压模座椅的舒适度得分为7.27±1.42,木质座椅的舒适度得分为5.36±3.14。结论,利用人体—座椅接触面温度特性来衡量座椅舒适度的客观评价体系具有一定的实用性和可靠性。 | 刘卓夫 李恩会 李峻夫 Cascioli Vincenzo Heusch I Andrew McCarthy W Peter | 2012 | 人类工效学2012，18，1： | 5 |
| 4 | Comparative effectiveness of i-SCAN^(TM) and high-definition white light characterizing small colonic polyps显示文摘AIM:To evaluate accuracy of in vivo diagnosis of adenomatous vs non-adenomatous polyps using i-SCAN digital chromoendoscopy compared with high-definition white light.METHODS:This is a single-center comparative effectiveness pilot study.Polyps(n = 103) from 75 averagerisk adult outpatients undergoing screening or surveillance colonoscopy between December 1,2010 and April 1,2011 were evaluated by two participating endoscopists in an academic outpatient endoscopy center.Polyps were evaluated both with high-definition white light and with i-SCAN to make an in vivo prediction of adenomatous vs non-adenomatous pathology.We determined diagnostic characteristics of i-SCAN and highdefinition white light,including sensitivity,specificity,and accuracy,with regards to identifying adenomatous vs non-adenomatous polyps.Histopathologic diagnosis was the gold standard comparison.RESULTS:One hundred and three small polyps,detected from forty-three patients,were included in the analysis.The average size of the polyps evaluated in the analysis was 3.7 mm(SD 1.3 mm,range 2 mm to 8 mm).Formal histopathology revealed that 54/103(52.4%) were adenomas,26/103(25.2%) were hyperplastic,and 23/103(22.3%) were other diagnoses include 'lymphoid aggregates','non-specific colitis,' and 'no pathologic diagnosis.' Overall,the combined accuracy of endoscopists for predicting adenomas was identical between i-SCAN(71.8%,95%CI:62.1%-80.3%) and high-definition white light(71.8%,95%CI:62.1%-80.3%).However,the accuracy of each endoscopist differed substantially,where endoscopist A demonstrated 63.0% overall accuracy(95%CI:50.9%-74.0%) as compared with endoscopist B demonstrating 93.3% overall accuracy(95%CI:77.9%-99.2%),irrespective of imaging modality.Neither endoscopist demonstrated a significant learning effect with i-SCAN during the study.Though endoscopist A increased accuracy using i-SCAN from 59%(95%CI:42.1%-74.4%) in the first half to 67.6%(95%CI:49.5%-82.6%) in the second half,and endoscopist B decreased accuracy using i-SCAN from 100%(95%CI:80.5%-100.0%) in the first half to 84.6%(95%CI:54.6%-98.1%) in the second half,neither of these differences were statistically significant.CONCLUSION:i-SCAN and high-definition white light had similar efficacy predicting polyp histology.Endoscopist training likely plays a critical role in diagnostic test characteristics and deserves further study. | Johanna L Chan Li Lin Michael Feiler Andrew I Wolf Diana M Cardona Ziad F Gellad | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 5 | Identification and characterization of mutations in hepatitis B virus resistant to Lamivudine显示文摘 | AllEN M I DESLAURIERS M ANDREWS C W | 1998 | Hepatology1998，27，6： | 2 |
| 6 | 人体-座椅接触面温湿度采集系统设计与实现显示文摘介绍了一种人体-座椅接触面温湿度采集系统,该系统采用AM2301温湿度传感器,经单片机处理后,由液晶屏实时显示温度和相对湿度数据,并将数据储存到SD卡中,供离线分析使用.在进行测量实验前,对系统所使用的3个温湿度传感器的输出一致性进行了测试,测试结果显示:AM2301传感器温度标准方差为±0.3℃,相对湿度标准方差为±0.5%,满足系统设计要求.利用该系统对5名志愿者进行了人体-座椅接触面温湿度采集实验,每次采集时间为1 h.测量结果分析表明:实验中三个温湿度传感器所在位置温度差别很小,而相对湿度却差别很大,反映了人体-座椅接触面相对湿度受传感器布放位置的影响很大. | 刘卓夫 罗中明 姜伟 CASCIOLI Vincenzo HEUSCH I Andrew MCCARTHY W Peter | 2013 | 哈尔滨理工大学学报2013，18，6： | 2 |
| 7 | Real-time markerless tracking for augmented reality: the virtuai visual servoing framework 显示文摘 | Muriel Pressigout Andrew I Comport Eric Marchand | 2006 | IEEE Transactions on Visualization and Computer Graphics Archive2006，12，4： | 1 |
| 8 | Three-Dimensional Modelling of a Helixchanger Heat Exchanger Using CFD 显示文摘 | Andrews M Master B I | 2005 | Heat Transfer Engineering2005，26，6： | 1 |
| 9 | The Design of High - Efficiency Line -Start Motors显示文摘 | Andrew M Knight Catherine I McClay | 2000 | IEEE Transactions on Industry Applications2000，36，6： | 1 |
| 10 | Preopera- tive anxiety and emergence delirium and postoperative maladap- tire behaviors显示文摘 | Kain ZN Caldwell-- Andrews AA Maranets I | 2004 | Anesth Anal2004，99，6： | 1 |
| 11 | Behavioural disorders, disability and quality of life in Parkinson' s disease显示文摘 | Leroi I Ahearn D J Andrews M | 2011 | Age Ageing2011，40，： | 1 |
| 12 | Comparing apples to oranges :Productivity convergence and measurement across indus-tries and countries 显示文摘 | Andrew B B Charles I J | 1996 | American Economic Review1996，，5： | 1 |
| 13 | 查看详情显示文摘 | James I L Tom D M Salah E Andrew F Karl H S Russell P N | | 0，，： | 1 |
| 14 | 3-D Printing of open source appropriate technologies for self-directed sustainable development显示文摘 | Pearce JM Morris Blair C Laciak KJ Andrews R Nosrat A Zelenika-Zovko I | 2010 | J Sustain Dev2010，3，4： | 1 |
| 15 | Hypnosis for pain relief in labor and childbirth显示文摘 | Cyna M McAuliffe G L Andrew M I | 2004 | British Journal of Anaesthesia2004，93，4： | 1 |
| 16 | Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA显示文摘 | Andrews RM Kubacka I Chinnery PF | 1999 | Nat Genet1999，23，2： | 1 |
| 17 | Carer burden in apathy and impulse control disorders in Parkinson' s disease显示文摘 | Leroi I Harbishettar V Andrews M | 2012 | Int J Geriatr Psychiatry2012，27，： | 1 |
| 18 | Latent dirichlet allocation 显示文摘 | Blei O M Andrew Y N Michael I J | 2003 | Journal of Machine Learning Research2003，3，1： | 1 |
| 19 | Reanalysis and revision of the Cambridge reference sequence for human mi?tochondrial DNA显示文摘 | Andrews RM Kubacka I Chinnery PF et a1 | 1999 | Nat Genet1999，23，2： | 1 |
| 20 | Pulmonary and cardiac sequelac of subarachnoid hemorrhage:time for active management显示文摘 | Macmillan C S Grant I S Andrews P J | 2002 | Intensive Care Med2002，28，： | 1 |
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