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| 1 | A 2D DEM-LBM study on soil behaviour due to locally injected fluid显示文摘Leakage from underground pipes could result in foundations being undermined and cause damage to adjacent infrastructure. Soil particles surrounding the leaking area could be mobilised, displaced, and even washed out of the soil matrix by the leaking fluid, generating a void or cavity. A two-dimensional simulation using a coupled discrete element method and lattice Boltzmann method (DEM-LBM) has been used to investigate the behaviour of a soil bed subject to a locally injected fluid, which represents a leak in a pipe. Various values of inter-particle surface energy were also adopted to model the mechanical effects of cohesive particles. The results suggest that the inter-particle surface energy greatly influences the bed response with respect to the leaking fluid, including the excess pressure initiating the cavity, the cavity shape and its evolution rate. | Xilin Cui Jun Li Andrew Chan David Chapman | 2012 | Particuology2012，10，2： | 6 |
| 2 | The Genetics of Complex Cholestatic Disorders显示文摘 | Gideon M. Hirschfield Roger W. Chapman Tom H. Karlsen Frank Lammert Konstantinos N. Lazaridis Andrew L. Mason | 2013 | Gastroenterology2013，，7： | 2 |
| 3 | Assessment of the application of bioanalytical tools as surrogate measure of chemical contaminants in recycled water显示文摘 | Frederic D.L. Leusch Stuart J. Khan Somprasong Laingam Erik Prochazka Suzanne Froscio Trang Trinh Heather F. Chapman Andrew Humpage | 2014 | Water Research2014，，： | 1 |
| 4 | The polypeptide backone of recombinant human zona pellucida glyeoprotein-3 initiates acrosomal exocytosisin human spermatozoa in vitro显示文摘 | Chapman N Kessopoulou E Andrews P D | 1998 | Biochem J1998，330，： | 1 |
| 5 | Clinical efficacy and cost-effectiveness of outpatient parenteral antibiotic therapy (OPAT): a UK perspective 显示文摘 | Chapman AL Dixon S Andrews D | 2009 | J Antimicrob Chemother2009，64，6： | 1 |
| 6 | 7-oxysterols modulateglucocorticoid activity in adipocytes through competition for 11 beta-hydroxysteroid dehydrogenase type 显示文摘 | Wamil M Andrew R Chapman KE | 2008 | Endocrinology2008，149，12： | 1 |
| 7 | Gylated antibodies and antibody fragments for improved therapy:a review显示文摘 | Andrew P Chapman PE | | 0，，： | 1 |
| 8 | 30 nm Chromatin Fibre Decompaction Requires both H4-K16 Acetylation and Linker Histone Eviction显示文摘 | Philip J.J. Robinson Woojin An Andrew Routh Fabrizio Martino Lynda Chapman Robert G. Roeder Daniela Rhodes | 2008 | Journal of Molecular Biology2008，，4： | 1 |
| 9 | Leg muscle recruitment during cycling is less developed in triathletes than cyclists despite matched cycling training loads显示文摘 | Andrew R. Chapman Bill Vicenzino Peter Blanch Paul W. Hodges | 2007 | Experimental Brain Research2007，，3： | 1 |
| 10 | Direet Removal of Edge-Localized Pollutant Emission in a Near-Infrared Bremsstrahlung Measurement显示文摘 | Anderson J K Andrew P L Chapman B E | 2003 | Review of Scientific Instruments2003，74，3： | 1 |
| 11 | The safety of 6-mercaptopurine for childbearing patients with inflammatory bowel disease: A retrospective cohort study显示文摘 | Andrew Francella Alan Dyan Carol Bodian Peter Rubin Mark Chapman Daniel H. Present | 2003 | Gastroenterology2003，，： | 1 |
| 12 | Telomerase catalytic subunit homologs from fission yeast and human显示文摘 | Morin GB Chapman KB Weinerich SL Andrews WH Lingner J | 1997 | Science1997，277，5328： | 1 |
| 13 | Clinical efficacy and cost-effectiveness of outpatient parenteral antibiotic therapy(OPAT):a UK perspective显示文摘 | Chapman AL Dixon S Andrews D | 2009 | J Antimicrob Chemother2009，64，6： | 1 |
| 14 | The polypeptide backbone of recombinant human zona pellucida glycoprotein-3 initiates acrosomal exocytosis in human spermatozoa in vitro显示文摘 | Chapman NR Kessopoulou E Andrews PD | | 0，，： | 1 |
| 15 | The polypeptide backone of recombinant human zona pellucida glycoprotein-3 initiates acrosomal exocytosis in human spermatozoa in vitro 显示文摘 | Chapman N Kessopoulou E Andrews PD | 1998 | Biochem J1998，330，： | 1 |
| 16 | Medium-term mortality after hip fractures and COVID-19:A prospective multicentre UK study显示文摘Purpose:The COVID-19 pandemic has caused 1.4 million deaths globally and is associated with a 3-4 times increase in 30-day mortality after a fragility hip fracture with concurrent COVID-19 infection.Typically,death from COVID-19 infection occurs between 15 and 22 days after the onset of symptoms,but this period can extend up to 8 weeks.This study aimed to assess the impact of concurrent COVID-19 infection on 120-day mortality after a fragility hip fracture.Methods:A multi-centre prospective study across 10 hospitals treating 8%of the annual burden of hip fractures in England between 1st March and 30th April,2020 was performed.Patients whose surgical treatment was payable through the National Health Service Best Practice Tariff mechanism for'fragility hip fractures'were included in the study.Patients'120-day mortality was assessed relative to their perioperative COVID-19 status.Statistical analysis was performed using SPSS version 27.Results:A total of 746 patients were included in this study,of which 87(11.7%)were COVID-19 positive.Mortality rates at 30-and 120-day were significantly higher for COVID-19 positive patients relative to COVID-19 negative patients(p<0.001).However,mortality rates between 31 and 120-day were not significantly different(p=0.107),16.1%and 9.4%respectively for COVID-19 positive and negative patients,odds ratio 1.855(95%CI 0.865-3.978).Conclusion:Hip fracture patients with concurrent COVID-19 infection,provided that they are alive at day-31 after injury,have no significant difference in 120-day mortality.Despite the growing awareness and concern of 'long-COVID'and its widespread prevalence,this does not appear to increase mediumterm mortality rates after a hip fracture. | Gareth Chan Ashish Narang Arash Aframian Zaid Ali Joseph Bridgeman Alastair Carr Laura Chapman Henry Goodier Catrin Morgan Chang Park Sarah Sexton Kapil Sugand Thomas Walton Michael Wilson Ajay Belgaumkar Kieran Gallagher Koushik Ghosh Charles Gibbons Joshua Jacob Andrew Keightley Zuhair Nawaz Khaled Sarraf Christopher Wakeling William Kieffer Benedict Rogers | 2022 | Chinese Journal of Traumatology2022，25，3： | 0 |
| 17 | 哮喘指南的成熟时期显示文摘首届国际哮喘指南会议约20g前在多伦多举行,此次会议达成的一致共识次年被公开发表。自此,许多国家和国际学会已经将哮喘指南作为循证医学资料。然而,这些资料建立的目的和针对的人群又是什么呢?指南的作者很少能够准确地阐明特定读者和预期结果,但人们普遍认为:指南的制订是针对初级保健内科医师,他们面对大多数哮喘患者;建立指南的目的是改进对哮喘的管理。在确定目标读者和预期结果方面的失误可能可以解释为什么指南常常无法达到制订者的期望。 | R Andrew Mclvor Kenneth R Chapman 陈云茹(译) | 2009 | 世界临床医学2009，，4： | 0 |
| 18 | Estimating Photosynthetic Attributes from High-Throughput Canopy Hyperspectral Sensing in Sorghum显示文摘Sorghum,a genetically diverse C_(4) cereal,is an ideal model to study natural variation in photosynthetic capacity.Specific leaf nitrogen(SLN)and leaf mass per leaf area(LMA),as well as,maximal rates of Rubisco carboxylation(V cmax),phosphoenolpyruvate(PEP)carboxylation(V pmax),and electron transport(J max),quantified using a C_(4) photosynthesis model,were evaluated in two field-grown training sets(n=169 plots including 124 genotypes)in 2019 and 2020. | Xiaoyu Zhi Sean Reynolds Massey-Reed Alex Wu Andries Potgieter Andrew Borrell Colleen Hunt David Jordan Yan Zhao Scott Chapman Graeme Hammer Barbara George-Jaeggli | 2022 | Plant Phenomics2022，4，1： | 0 |
| 19 | X-ray focusing with efficient high-NA multilayer Laue lenses显示文摘Multilayer Laue lenses are volume diffraction elements for the efficient focusing of X-rays.With a new manufacturing technique that we introduced,it is possible to fabricate lenses of sufficiently high numerical aperture(NA)to achieve focal spot sizes below 10 nm.The alternating layers of the materials that form the lens must span a broad range of thicknesses on the nanometer scale to achieve the necessary range of X-ray deflection angles required to achieve a high NA.This poses a challenge to both the accuracy of the deposition process and the control of the materials properties,which often vary with layer thickness.We introduced a new pair of materials—tungsten carbide and silicon carbide—to prepare layered structures with smooth and sharp interfaces and with no material phase transitions that hampered the manufacture of previous lenses.Using a pair of multilayer Laue lenses(MLLs)fabricated from this system,we achieved a two-dimensional focus of 8.4×6.8 nm2 at a photon energy of 16.3 keV with high diffraction efficiency and demonstrated scanning-based imaging of samples with a resolution well below 10 nm.The high NA also allowed projection holographic imaging with strong phase contrast over a large range of magnifications.An error analysis indicates the possibility of achieving 1 nm focusing. | Saša Bajt Mauro Prasciolu Holger Fleckenstein Martin Domaracký Henry N Chapman Andrew J Morgan Oleksandr Yefanov Marc Messerschmidt Yang Du Kevin T Murray Valerio Mariani Manuela Kuhn Steven Aplin Kanupriya Pande Pablo Villanueva-Perez Karolina Stachnik Joe PJ Chen Andrzej Andrejczuk Alke Meents Anja Burkhardt David Pennicard Xiaojing Huang Hanfei Yan Evgeny Nazaretski Yong S Chu Christian E Hamm | 2017 | Light(Science & Applications)2017，6，1： | 0 |
| 20 | Augmenting the conservation value of rehabilitated wildlife by integrating genetics and population modeling in the post-rehabilitation decision process显示文摘 | Carlo PACIONI Chris RAFFERTY Kelly MORLEY Sarah STEVENSON Andrew CHAPMAN Michael WICKINS Terry VERNEY Gerry DEEGAN Sabrina TROCINI Peter B. S, SPENCER | 2018 | Current Zoology2018，64，5： | 0 |
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