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| 1 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 2 | Antimicrobial activity of a bovine hemoglobin fragment in the tick Boophilus rnicroplus 显示文摘 | Andrea C F Pedro I Teresa M | 1999 | The Journal of Biological Chemistry1999，274，25： | 1 |
| 3 | Renal insufficiency following contrast media administration trial(REMEDIAL):arandomized comparison of 3 preventive strategies显示文摘 | Briguori c Airoldi F D'Andrea D | 2007 | Circulation2007，115，10： | 1 |
| 4 | Determination of bonding in diamond-like carbon by Raman spectroscopy显示文摘 | Andrea C F | 2002 | Diamond and related materials2002，11，： | 1 |
| 5 | Cerebral microbleeds andrecurrent stroke risk: systematic review and Meta-analysis ofprospective ischemic stroke and transient ischemic attackcohorts 显示文摘 | Andreas C Puneet K Zoe F | 2013 | Stroke2013，44，4： | 1 |
| 6 | Infrarenal aortic and lower-extremity arterial disease: diagnostic performance of multidetector row CT angiography显示文摘 | Carlo C Francesco F Andrea L | 2004 | Radiology2004，231，： | 1 |
| 7 | Major Proteins of Beer and Their Precursors in Barley : Electrophoretic and Immunolog- ical Studies 显示文摘 | Andrea C Giovanna P Luca F | 1995 | Journal of Agricultural and Food Chemistry1995，43，10： | 1 |
| 8 | Renal insufficiency following contrast media administration trial (REMEDIAL):a randomized comparison of 3 preventive strategics显示文摘 | Briguori C Airoldi F D'Andrea D | 2007 | Circulation2007，115，： | 1 |
| 9 | Renal Insufficiency Following Contrast Media Administration Trial (REMEDIAL):a randomized comparison of 3 preventive strategies显示文摘 | Briguori C Airoldi F D'Andrea D | | 0，，10： | 1 |
| 10 | Peripheral facial palsy secondary to middle-ear overpressure显示文摘 | Andrea C Meliet JL Staikowski F | 2008 | Presse Med2008，37，42： | 1 |
| 11 | A Measure of Absorptive Capacity: Scale Development and Validation显示文摘 | Tessa C F Andreas E Shaker A Z | 2011 | European Management Journal2011，29，2： | 1 |
| 12 | Renal insufficien ey following contrast media administration trial(REME DIAL):a randomized comparison of 3 preventive strate gies显示文摘 | Briguori C Airoldi F D' Andrea D | 2007 | Circulation2007，115，10： | 1 |
| 13 | AHP-based evaluation of CMMS software 显示文摘 | Marcello B Gionata C Marco F Andrea G | 2006 | Journal of Manufacturing Technology Management2006，17，5： | 1 |
| 14 | Swallowing disorders, pneumonia and respiratory tract infectious disease in the elderly 显示文摘 | Puisieux F D'Andrea C Baconnier P | 2011 | Rev Mal Respir2011，28，8： | 1 |
| 15 | Psychiatric aspects of organ transplantation in critical care 显示文摘 | Andrea DM Catherine C Marian F | 2008 | Critical Care Clinics2008，24，4： | 1 |
| 16 | A Visual GlobalPositioning System for Unmanned Aerial Vehicles Used in Photogrammetric Applications显示文摘 | Andrea C Emanuele F Adriano M | | 0，，01： | 1 |
| 17 | T-regulatory cells: key players in tumor immune escape and angiogenesis显示文摘 | Andrea F Motz GT George C | 2012 | Cancer Res2012，72，23： | 1 |
| 18 | Experimental and analytical response of masonry elements under eccentric vertical loads显示文摘 | LIBORIO C ANDREA F LIDIA L M | 2005 | Engineering Structures2005，27，8： | 1 |
| 19 | Infrarenal aortic and lower-extremity arterial disease:diagnostic performance of multi-detector row CT angiography显示文摘 | Carlo C Francesco F Andrea L | 2004 | Radiology2004，231，2： | 1 |
| 20 | Microwave-assisted phase-transfer catalysis for the rapid one-pot methylation and gas chromatographic determination of phenolics显示文摘 | Yiannis C F Andreas K Constantine D S | 2010 | Journal of the ChromatographA2010，1217，： | 1 |
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