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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Human mesenchymal stem cells from the umbilical cord matrix: Successful isolation and ex vivo expansion using serum‐/xeno‐free culture media显示文摘 | Irina N. Sim?es Joana S. Boura Francisco dos Santos Pedro Z. Andrade Carla M. P. Cardoso Jeffrey M. Gimble Cláudia L. da Silva Joaquim M. S. Cabral | 2013 | Biotechnology Journal2013，，4： | 1 |
| 3 | Effect of Moringa oleifera lectins on survival and enzyme activities of Aedes aegypti larvae susceptible and resistant to organophosphate显示文摘 | Afonso Cordeiro Agra-Neto Thiago Henrique Napole?o Emmanuel Viana Pontual Nataly Diniz Lima Santos Luciana Andrade Luz Cláudia Maria Fontes Oliveira Maria Alice Varjal Melo-Santos Luana Cassandra Breitenbach Barroso Coelho Daniela Maria Amaral Ferraz Nava | 2014 | Parasitology Research2014，，1： | 1 |
| 4 | Antiulcerogenic activity of Alchornea castaneaefolia : Effects on somatostatin, gastrin and prostaglandin显示文摘 | Clélia Akiko Hiruma-Lima Tamara Roberta Calvo Clenilson Martins Rodrigues Fábio Donizete Pezzuto Andrade Wagner Vilegas Alba Regina Monteiro Souza Brito | 2005 | Journal of Ethnopharmacology2005，，1： | 1 |
| 5 | Nd:YAG laser clinical assisted in class II furcation treatment显示文摘 | Ana Karina Pinto Andrade Ilíria Salom?o Feist Cláudio Mendes Pannuti Silvana Cai Denise Maria Zezell Giorgio Micheli | 2008 | Lasers in Medical Science2008，，4： | 1 |
| 6 | In situ apoptosis of adaptive immune cells and the cellular escape of rabies in CNS from patients with human rabies transmitted by Desmodus rotundus显示文摘 | Fernandes ER de Andrade HF Jr Laneellotti CL | 2011 | Virus Res2011，156，12： | 1 |
| 7 | Evaluation of prevalence in the treatment of mandible condyle fractures显示文摘 | Rampaso CL Mattioli TM de Andrade Sobrinho J | 2012 | Rev Col Bras Cir2012，39，5： | 1 |
| 8 | An investigation of learning during propofol sedation and anesthesia using the process disso-ciation procedure显示文摘 | STAPLETON CL ANDRADE J | 2000 | Anesthesiology2000，93，6： | 1 |
| 9 | Pregnancy and acute pulmonary embolism: A case report显示文摘 | Luís Ferreira dos Santos Cláudia Andrade Bruno Rodrigues Davide Moreira Anne Delgado Pedro Manso António Pipa Pedro Gama Luís Nunes Odete Dionísio Nuno Ribeiro Oliveira Santos | 2012 | Revista Portuguesa de Cardiologia (English Edition)2012，，5： | 1 |
| 10 | An investigation of learning during propofol sedation and anesthesia using the process dis-sociation procedure显示文摘 | STAPLETON CL ANDRADE J | 2000 | Anesthesiology2000，93，6： | 1 |
| 11 | A morphometric study on the longitudinal and lateral symmetry of the sural nerve in mature and aging female rats显示文摘 | André Jeronimo Cláudia Além Domingues Jeronimo Omar Andrade Rodrigues Filho Luciana Sayuri Sanada Valéria Paula Sassoli Fazan | 2008 | Brain Research2008，，： | 1 |
| 12 | Evaluation of prevalence in the treatment of mandible condyle fractures显示文摘 | Rampaso CL Mattioli TM de Andrade Sobrinho J | 2012 | Rev Col Bras Cir2012，39，5： | 1 |
| 13 | An investigation of learning during propofol sedation and anesthesia using the process dissociation procedure显示文摘 | STAPLETON CL ANDRADE J | 2000 | Anesthesiology2000，93，6： | 1 |
| 14 | 14th International Congress on Antiphospholipid Antibodies: task force report on antiphospholipid syndrome treatment trends显示文摘 | Erkan D Aguiar CL Andrade D | 2014 | Autoimmun Rev2014，13，6： | 1 |
| 15 | Effects that bovine sperm cryopreservation using two different extenders has on sperm membranes and chromatin显示文摘 | Eneiva Carla Carvalho Celeghini Rubens Paes de Arruda André Furugen Cesar de Andrade Juliana Nascimento Cláudia Fernandes Raphael Paulo Henrique Mazza Rodrigues | 2007 | Animal Reproduction Science2007，，2： | 1 |
| 16 | An investigation of learning during propofol sedation and anesthesia using the process dissociation procedure显示文摘 | STAPLETON CL ANDRADE J | 2000 | Anesthesiology2000，93，6： | 1 |
| 17 | 5-year follow-up report显示文摘 | Andrade Cl Goncalves TM Santas IL Direct adhesive pin-re- tained restorations for severely worn dentition treatment: a 1 | 2014 | Braz Dent J2014，25，4： | 1 |
| 18 | Arsenic Root Sequestration by a Tropical Woody Legume as Affected by Arbuscular Mycorrhizal Fungi and Organic Matter: Implications for Land Reclamation显示文摘 | Marcelo P Gomes Marina Lages Andrade Clésia C Nascentes Maria Rita Scotti | 2014 | Water Air & Soil Pollution2014，，4： | 1 |
| 19 | 14th International Congress on Antiphospholipid Antibodies: task force report on antiphospho- lipid syndrome treatment trends显示文摘 | Erkan D Aguiar CL Andrade D | 2014 | Autoimmun Rev2014，13，： | 1 |
| 20 | Evaluation of prevalence in the treatment of mandible condyle fractures显示文摘 | Rampaso CL Mattioli TM de Andrade Sobrinho J | 2012 | Rev Col Bras Cir2012，39，5： | 1 |
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