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| 1 | Role of adipokines and peroxisome proliferator-activated receptors in nonalcoholic fatty liver disease显示文摘Intrahepatic fat deposition has been demonstrated in patients with nonalcoholic fatty liver disease(NAFLD). Genetic and environmental factors are important for the development of NAFLD. Diseases such as obesity, diabetes, and hypertension have been found to be closely associated with the incidence of NAFLD. Evi-dence suggests that obesity and insulin resistance are the major factors that contribute to the development of NAFLD. In comparing the factors that contribute to the buildup of excess calories in obesity, an imbalance of energy homeostasis can be considered as the basis. Among the peripheral signals that are generated to regulate the uptake of food, signals from adipose tissue are of major relevance and involve the maintenance of energy homeostasis through processes such as lipo-genesis, lipolysis, and oxidation of fatty acids. Advances in research on adipose tissue suggest an integral role played by adipokines in NAFLD. Cytokines secreted by adipocytes, such as tumor necrosis factor-α, transform-ing growth factor-β, and interleukin-6, are implicated in NAFLD. Other adipokines, such as leptin and adiponectin and, to a lesser extent, resistin and retinol binding protein-4 are also involved. Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription fac-tors, namely peroxisome proliferator-activated receptor(PPAR)-α. Recent studies have proposed downregula-tion of PPAR-α in cases of hepatic steatosis. This re-view discusses the role of adipokines and PPARs with regard to hepatic energy metabolism and progression of NAFLD. | Vettickattuparambil George Giby Thekkuttuparambil Ananthanarayanan Ajith | 2014 | World Journal of Hepatology2014，6，8： | 30 |
| 2 | Mitochondria-targeted agents: Future perspectives of mitochondrial pharmaceutics in cardiovascular diseases显示文摘Mitochondria are one of the major sites for the genera-tion of reactive oxygen species(ROS) as an undesirable side product of oxidative energy metabolism. Damaged mitochondria can augment the generation of ROS. Dys-function of mitochondria increase the risk for a large number of human diseases, including cardiovascular diseases(CVDs). Heart failure(HF) following ischemic heart disease, infantile cardiomyopathy and cardiac hypertrophy associated with left ventricular dilations are some of the CVDs in which the role of mitochon-drial oxidative stress has been reported. Advances in mitochondrial research during the last decade focused on the preservation of its function in the myocardium, which is vital for the cellular energy production. Expe-rimental and clinical trials have been conducted using mitochondria-targeted molecules like: MnSOD mimetics, such as EUK-8, EUK-134 and MitoSOD; choline esters of glutathione and N-acetyl-L-cysteine; triphenylphospho-nium ligated vitamin E, lipoic acid, plastoquinone andmitoCoQ10; and Szeto-Schiller(SS)- peptides(SS-02 and SS-31). Although many results are inconclusive, some of the findings, especially on CoQ10, are worthwhile. This review summarizes the role of mitochondria-tar-geted delivery of agents and their consequences in the control of HF. | Thekkuttuparambil Ananthanarayanan Ajith Thankamani Gopinathan Jayakumar | 2014 | World Journal of Cardiology2014，6，10： | 7 |
| 3 | Signal Detection and Channel Estimation in OTFS显示文摘Orthogonal time frequency space(OTFS)modulation is a recently proposed modulation scheme that exhibits robust performance in high-Doppler environments.It is a two-dimensional modulation scheme where information symbols are multiplexed in the de⁃lay-Doppler(DD)domain.Also,the channel is viewed in the DD domain where the chan⁃nel response is sparse and time-invariant for a long time.This simplifies channel estima⁃tion in the DD domain.This paper presents an overview of the state-of-the-art approaches in OTFS signal detection and DD channel estimation.We classify the signal detection ap⁃proaches into three categories,namely,low-complexity linear detection,approximate max⁃imum a posteriori(MAP)detection,and deep neural network(DNN)based detection.Simi⁃larly,we classify the DD channel estimation approaches into three categories,namely,separate pilot approach,embedded pilot approach,and superimposed pilot approach.We compile and present an overview of some of the key algorithms under these categories and illustrate their performance and complexity attributes. | Ashwitha NAIKOTI Ananthanarayanan CHOCKALINGAM | 2021 | ZTE Communications2021，19，4： | 2 |
| 4 | 胰高血糖素基因克隆、表达及鉴定显示文摘目的 研制基因工程胰高血糖素,用于治疗因注射胰岛素或口服抗糖尿病药物而引起的严重低血 糖反应。方法 依据人胰高血糖素氨基酸组成序列,采用大肠杆菌出现频率高的氨基酸密码子,体外合成胰高血 糖素基因序列,克隆于pGEX-1N质粒,转化人BL21(DE3)菌中,对阳性克隆转化质粒进行DNA测序。用IPTG诱导 转化的胰高血糖素工程菌,产生谷胱苷肽转移酶的融合蛋白,经谷胱苷肽Sepharose4B亲和层析后,由 Factor Xa酶 进行柱上切割,最后用RP-HPLC得到纯化产物。产品用质谱法测相对分子质量,并对N末端15个氨基酸测序。 结果DNA测序显示克隆基因序列正确,产品相对分子质量为3486J末端15个氨基酸序列与理论值相同,产率为 1.9mg/L。结论 获得以可溶性融合蛋白方式表达的胰高血糖素基因工程菌,适于快速生产天然序列重组胰高血 糖素。 | 母敬郁 张桂荣 王峤 尚庆义 杨翰仪 Joni Lukwanize Wettai Ananthanarayanan VS | 2001 | 中国生物制品学杂志2001，14，2： | 2 |
| 5 | Fabrication and photophysical studies of phenosafranine and proflavine dyes encapsulated in mesoporous MCM-41 along with titanium dioxide nanoparticles 显示文摘 | Ananthanarayanan K Natarajan P | 2009 | Microporous and Mesoporous Materials2009，124，1： | 1 |
| 6 | A review of probes and robots: implementing new technologies in meat evaluation显示文摘 | SWATLAND H J ANANTHANARAYANAN S P GOLDENBERG A A | 1994 | Journal of Animal Science1994，72，： | 1 |
| 7 | Human bile salt export pump promoter is transactivated by the famesoid X receptorlbile acid receptor显示文摘 | Ananthanarayanan M Balasubramanian N Makishima M Man- gelsdorf D J Suchy FJ | 2001 | J Biol Chem2001，276，28： | 1 |
| 8 | Cognitive Computing显示文摘 | Modha D S Ananthanarayanan R Esser S K | 2011 | Communications of the ACM (S0001-0782)2011，54，8： | 1 |
| 9 | Bile Salt Excretory Pump: Biology and Pathobiology显示文摘 | Frederick J. Suchy M. Ananthanarayanan | 2006 | Journal of Pediatric Gastroenterology and Nutrition ( Suppl )2006，，1： | 1 |
| 10 | Tunable excitonic emission of monolayer WS2 for the optical detection of DNA nucleobases显示文摘 | Shun Feng Chunxiao Cong Namphung Peimyoo Yu Chen Jingzhi Shang Chenji Zou Bingchen Cao Lishu Wu Jing Zhang Mustafa Eginligil Xingzhi Wang Qihua Xiong Arundithi Ananthanarayanan Peng Chen Baile Zhang Ting Yu | 2018 | Nano Research2018，11，3： | 1 |
| 11 | Differenial developmental regulation of rat liver canalicular membrane transporters Bsep and Mrp2显示文摘 | Tomer G Ananthanarayanan M Weymann A | 2003 | Pediatr Res2003，53，2： | 1 |
| 12 | Alteration of proliferation and apoptotic markers in normal and premalignant tissue associated with prostate cancer显示文摘 | Ananthanarayanan V Deaton R J Yang X J | 2006 | BMC Cancer2006，17，6： | 1 |
| 13 | Neural stem cell adhesion and proliferation on phospholipid bilayers functionalized with RGD peptides 显示文摘 | Badriprasad Ananthanarayanan Lauren Little David V Schaffer | 2010 | Biomaterials2010，31，： | 1 |
| 14 | Crystallization behavior of iron-containing inter metallic compounds in 319 aluminum alloy显示文摘 | ANANTHANARAYANAN L SAMUEL F H Gruzleski J E | 1994 | Metallurgical and Materials Transactions A1994，25，5： | 1 |
| 15 | Characterization and control of plastic deformation in mesoscale premolded components to realize in-mold assembled mesoscale revolute joints 显示文摘 | Ananthanarayanan A Gupta S K Bruck H A | 2009 | Polymer Engineering and Science2009，49，2： | 1 |
| 16 | Effect of the lipid chain melting transition on the stability of DSPE-PEG (2000) micelles显示文摘 | Kastantin M Ananthanarayanan B Karmali P | | 0，，13： | 1 |
| 17 | Experimental study on pore nuleation by indusinons in aluminum eastings 显示文摘 | ANANTHANARAYANAN L SAMUEL F H GRUZLESKI J E | 1992 | AFS Transactions1992，24，8： | 1 |
| 18 | Crystallization behavior of iron-containing intermetallic compounds in 319 aluminum alloy 显示文摘 | Ananthanarayanan L Samuel F H Gruzleski J E | 1994 | Metallurgical and Materials Transactions A: Physical Metallurgy and Materials Science1994，25，8： | 1 |
| 19 | Modeling and characterization to minimize effects of melt flow fronts on premolded component deformation during in-mold assembly of mesoscale revolute joints显示文摘 | Ananthanarayanan A Gupta S K Bruck H A | 2010 | Journal of Manufacturing Science and Engineering2010，132，04： | 1 |
| 20 | Heterogeneous activation of oxone using Co3 04 显示文摘 | EASWARAMOORTHI S ANANTHANARAYANAN K SREEDHAR B | 2005 | Journal of Physical Chemistry B2005，109，13： | 1 |
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