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| 1 | Resolution of non-alcoholic steatohepatitis by rosuvastatin monotherapy in patients with metabolic syndrome显示文摘AIM: To investigate the effect of rosuvastatin monotherapy on non-alcoholic steatohepatitis(NASH). At present there is no effective treatment for non-alcoholic fatty liver disease or its advanced form NASH.METHODS: This prospective study included 20 biopsy proven patients with NASH, metabolic syndrome(Met S) and dyslipidaemia. Biochemical parameters of the blood of the patients and an ultrasonography of the liver were performed at baseline. Then patients receivedlifestyle advice and were treated for a 12 mo period with rosuvastatin(10 mg/d) monotherapy. Patients were re-evaluated during the study at 3 mo intervals, during which biochemical parameters of the blood were measured including liver enzymes. A repeat biopsy and ultrasonography of the liver were performed at the end of the study in all 20 patients. Changes in liver enzymes, fasting plasma glucose, serum creatinine, serum uric acid(SUA), high sensitivity C reactive protein(hs CRP) and lipid profile were assessed every 3 mo. The primary endpoint was the resolution of NASH and the secondary endpoints were the changes in liver enzyme and lipid values.RESULTS: The repeat liver biopsy and ultrasonography showed complete resolution of NASH in 19 patients, while the 20 th, which had no improvement but no deterioration either, developed arterial hypertension and substantial rise in triglyceride levels during the study, probably due to changes in lifestyle including alcohol abuse. Serum alanine transaminase, aspartate transaminase, and γ-glutamyl transpeptidase were normalised by the 3rd treatment month(ANOVA P < 0.001), while alkaline phosphatase activities by the 6th treatment month(ANOVA, P = 0.01). Fasting plasma glucose and glycated haemoglobin were significantly reduced(P < 0.001). Lipid values were normalised by the 3rd treatment month. No patient had Met S by the 9th treatment month. Body mass index and waist circumference remained unchanged during the study. Thus, changes in liver pathology and function should be attributed solely to rosuvastatin treatment. A limitation of the study is the absence of a control group.CONCLUSION: These findings suggest that rosuvastatin monotherapy could ameliorate biopsy proven NASH and resolve Met S within 12 mo. These effects and the reduction of fasting plasma glucose and SUA levels may reduce the risk of vascular and liver morbidity and mortality in NASH patients. These findings need confirmation in larger studies. | Konstantinos Kargiotis Vasilios G Athyros Olga Giouleme Niki Katsiki Evangelia Katsiki Panagiotis Anagnostis Chrysoula Boutari Michael Doumas Asterios Karagiannis Dimitri P Mikhailidis | 2015 | World Journal of Gastroenterology2015，21，25： | 18 |
| 2 | Polycystic ovary syndrome and type 2 diabetes mellitus:A state-ofthe-art review显示文摘Polycystic ovary syndrome(PCOS)often coexists with a wide spectrum of dysglycemic conditions,ranging from impaired glucose tolerance to type 2 diabetes mellitus(T2D),which occur to a greater extent compared to healthy body mass index-matched women.This concurrence of disorders is mainly attributed to common pathogenetic pathways linking the two entities,such as insulin resistance.However,due to methodological flaws in the available studies and the multifaceted nature of the syndrome,there has been substantial controversy as to the exact association between T2D and PCOS which has not yet been elucidated.The aim of this review is to present the best available evidence regarding the epidemiology of dysglycemia in PCOS,the unique pathophysiological mechanisms underlying the progression of dysglycemia,the most appropriate methods for assessing glycemic status and the risk factors for T2D development in this population,as well as T2D risk after transition to menopause.Proposals for application of a holistic approach to enable optimal management of T2D risk in PCOS are also provided.Specifically,adoption of a healthy lifestyle with adherence to improved dietary patterns,such the Mediterranean diet,avoidance of consumption of endocrine-disrupting foods and beverages,regular exercise,and the effect of certain medications,such as metformin and glucagon-like peptide 1 receptor agonists,are discussed.Furthermore,the maintenance of a healthy weight is highlighted as a key factor in achievement of a significant reduction of T2D risk in women with PCOS. | Sarantis Livadas Panagiotis Anagnostis Julia K Bosdou Dimitra Bantouna Rodis Paparodis | 2022 | World Journal of Diabetes2022，13，1： | 4 |
| 3 | Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis显示文摘 | Vasilios G Athyros Konstantinos Tziomalos Thomas D Gossios Theodora Griva Panagiotis Anagnostis Konstantinos Kargiotis Efstathios D Pagourelias Eleni Theocharidou Asterios Karagiannis Dimitri P Mikhailidis | 2010 | The Lancet2010，，9756： | 2 |
| 4 | Thyroid dysfunction and long -term outcome during and after interferon -alpha therapy in patients with chronic hepatitis C 显示文摘 | VASILIADIS T ANAGNOSTIS P NALMPANTIDIS G | 2011 | Ann Acad Med Singapore2011，40，9： | 1 |
| 5 | Ectopic thyroid tissue:anatomical,clinical,and surgical implications of a rare entity显示文摘 | NOUSSIOS G ANAGNOSTIS P GOULIS D G | 2011 | Eur J Endocrinol2011，165，： | 1 |
| 6 | Clinical review:thepathogenetic role of cortisol in the metabolic syndrome:a hypothesis显示文摘 | Anagnostis P Athyros VG Tziomalos K | 2009 | J Clin Endocrinol Metab2009，94，8： | 1 |
| 7 | Ectopic thy- roid tissue:anatomical, clinical,and surgical implications of a rare entity显示文摘 | Noussios G Anagnostis P Goulis D G | 2011 | Eur J Endocrinol2011，165，： | 1 |
| 8 | Comparative effects of rosuvastatin and atorvastatin on glucose metabolism and adipokine levels in non-diabetic patients with dyslipi- daemia:a prospective randomised open-label study 显示文摘 | Anagnostis P Selalmatzidou D Polyzos SA | 2011 | Int J Clin Pract2011，65，6： | 1 |
| 9 | Thyroid diseases and female reproduction 显示文摘 | Mintziori G Anagnostis P Toulis KA | 2012 | Minerva Med2012，103，1： | 1 |
| 10 | Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis显示文摘 | Vasilios G Athyros Konstantinos Tziomalos Thomas D Gossios Theodora Griva Panagiotis Anagnostis Konstantinos Kargiotis Efstathios D Pagourelias Eleni Theocharidou Asterios Karagiannis Dimitri P Mikhailidis | 2010 | The Lancet2010，，9756： | 1 |
| 11 | Ectopie thyroid tis- sue : anatomical, clinical, and surgical implications of a rare entity 显示文摘 | Noussios G Anagnostis P Goulis DG | 2011 | European Journal of Endocrinology2011，165，3： | 1 |
| 12 | Clinical review:the pathogenetic role of cortisol in themetabolic syndrome:a hypothesis显示文摘 | Anagnostis P Athyros VG Tziomalos K | | 0，，08： | 1 |
| 13 | The pathoge- netic role of cortisol in the metabolic syndrome : A hypothe- sis 显示文摘 | Anagnostis P Athyros VG Tziomalos K | 2009 | J Clin Endocrinol Metab2009，94，8： | 1 |
| 14 | Ectopic throid tissue : anatomical, clinical , mad surgical implications of a rare entity 显示文摘 | Noussios G Anagnostis P Goulis DG | 2011 | Eur J Endocrino12011，165，3： | 1 |
| 15 | Formulation of buprenorphine for sublingual use in neonates显示文摘 | ANAGNOSTIS EA SADAKA RE SAILOR LA | 2011 | J Pediatr Pharmaeol Ther2011，16，4： | 1 |
| 16 | Anatomy and clinical implications of the ultrasound-guided subsartorial saphenous nerve block显示文摘 | Saranteas T Anagnostis G Paraskeuopoulos T | 2011 | Reg Anesth Pain Med2011，36，4： | 1 |
| 17 | Reversible plasticization of nylon 6 and 11 with anhydrous ammonia and their deformation by solid-state coextrusion显示文摘 | ANAGNOSTIS E Z ROGER S P | 1979 | Journal of applied polymer science1979，24，： | 1 |
| 18 | Location, number and morphology of parathyroid glands: results from a large anatomical series显示文摘 | Lappas D Noussios G Anagnostis P Adamidou F Chatzigeorgiou A Skandalakis P | 2012 | Anat Sci Int2012，87，： | 1 |
| 19 | Clinical review: The pathogenetic role of cortisol in the metabolic syndrome: a hypothesis显示文摘 | Anagnostis P Athyros VG Tziomalos K | 2009 | J Clin Endocrinol Metab2009，94，： | 1 |
| 20 | Anatomy and clinical implications of the ultrasound - guided subsartorial saphenous nerve block 显示文摘 | Saranteas T Anagnostis G Paraskeuopoulos T | | Reg Anesth Pain Med0，36，4： | 1 |
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