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| 1 | Intestinal pseudo-obstruction caused by herpes zoster:Case report and pathophysiology显示文摘Herpes zoster(HZ) infection occurs in approximately 10% to 30% of individuals. Visceral neuropathies secondary to HZ can cause cystitis and urinary retention. But colonic pseudo-obstruction can also occur. Peripheral neuropathy may reveal segmental motor paresis of either upper or lower limbs, the abdominal muscles or the diaphragm. We report the case of a 62-year-old male patient who presented with abdominal distention and cutaneous vesicular eruption on the left side of the abdominal wall. Plain X-rays and computed tomography scan showed distended small bowel. A diagnosis of intestinal pseudo-obstruction was made secondary to segmental paresis of the small intestine and visceral neuropathy. Conservative management was successful and the patient was discharged uneventfully. Intestinal pseudo-obstruction ought to be consideredwhen dealing with non-obstructive(adynamic) conditions of the digestive tract associated with HZ infection; since early recognition may help to avoid unnecessary surgery. | Roberto Anaya-Prado José V Pérez-Navarro Ana Corona-Nakamura Michelle M Anaya-Fernández Roberto Anaya-Fernández Marian Eliza Izaguirre-Pérez | 2018 | World Journal of Clinical Cases2018，6，6： | 4 |
| 2 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients显示文摘 | Manuel Romero-Gómez Maria Del Mar Viloria Raúl J. Andrade Javier Salmerón Moisés Diago Conrado M. Fernández-Rodríguez Raquel Corpas Marina Cruz Lourdes Grande Luis Vázquez Paloma Mu?oz-de-Rueda Pilar López-Serrano Ana Gila María L. Gutiérrez Celia Pérez A | 2005 | Gastroenterology2005，，3： | 2 |
| 5 | Process mining for ubiquitous mobile systems: an overview and a concrete algorithm 显示文摘 | Ana K A d M Boudewijn F van D Wil M P v d A | 2004 | Ubiquitous Mobile Information and Collaboration Systems2004，3272，1： | 1 |
| 6 | Are island plant communi- ties more invaded than their mainland counterparts显示文摘 | Montserrat V Joan P Ana M | 2010 | Journal of Vegetation Science2010，21，3： | 1 |
| 7 | Heteroge- nous studies in pulping of wood: Modelling mass transfer of alkali 显示文摘 | Joao P F Simao Ana P V Egas M Graca Carvalho | 2008 | Chemical Engineering Jurnal2008，139，3： | 1 |
| 8 | Terminal restriction fragment length polymorphism analysis of ribosomal RNA genes to assess changes in fungal community structure in soils显示文摘 | Véronique Edel-Hermann Christiane Dreumont Ana Pérez-Piqueres Christian Steinberg | 2004 | FEMS Microbiology Ecology2004，，3： | 1 |
| 9 | Lipase-catalyzed production of biodiesel fuel from vegetable oils contained in waste activated bleaching earth 显示文摘 | ANA V LARA P ENOCH Y P | 2003 | Process Biochemistry2003，，38： | 1 |
| 10 | A duplex SYBR Green I based real-time RT-PCR assay for the simultaneous detection and differentiation of Massachusetts and non-Massachusetts serotypes of infectious bronchitis virus显示文摘 | Ana M A Carmen L P Armando V | 2013 | Mol Cell Probe2013，27，： | 1 |
| 11 | 2,4-Dichlorophenoxyacetic Acid (2,4-D) Degradation Promoted by Nanoparticulate Zero Valent Iron (nZVI) in Aerobic Suspensions显示文摘 | ADR/ANA C V RAQUEL F P | 2013 | Journal of Environmental Management2013，121，： | 1 |
| 12 | Serotonin transporter occupancy induced by paroxetinein patients with major depression disorder:a 123I-ADAM SPECT study显示文摘 | Ana M Peter V Plaza P | 2006 | Psychopharmacology2006，189，2： | 1 |
| 13 | The effect of amine type, pH, and size range in the flotation of quartz 显示文摘 | Ana M V Antonio E C P | 2007 | Minerals Engineering2007，20，10： | 1 |
| 14 | Spatial and seasonal variations of the macrobenthic community and metal contamination in the Douro estuary (Portugal) 显示文摘 | Ana P M Teresa S D V Adriano A B | 2005 | Marine Environmental Research2005，60，5： | 1 |
| 15 | MHC class II sequences of susceptibility and protection in Mexicans with autoimmune hepatitis显示文摘 | Miriam Nohemí Vázquez-García Carmen Aláez Angélica Olivo Héctor Debaz Elva Pérez-Luque Ana Burguete Silvia Cano Gabriela de la Rosa Norma Bautista Arturo Hernández José Bandera Luis Fernando Torres David Kershenobich Fernando Alvarez Clara Gorodezky | 1998 | Journal of Hepatology1998，，6： | 1 |
| 16 | Regulation of ACE2 and ANG-(1-7) in the aorta: new insights into the renin- angiotensin system in the control of vascular function 显示文摘 | Ana P V Dantas S Kathryn S | 2005 | Am J Physiol Heart Circ Physiol2005，289，9： | 1 |
| 17 | Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery显示文摘 | Carmen RL Ana P Jose Luis V J | 1998 | Journal of Controlled Release1998，55，23： | 1 |
| 18 | J Chromatogr A显示文摘 | Stoj anka V Bilj ana S Jelena V Ljilgana P A Goran R Dragan M | 2008 | 1202 (2) : 1552008，1202，2： | 1 |
| 19 | An invitro and in vivo investigation of the biological behavior of a ferrimagnetic ce?ment for highly focalized thermotherapy显示文摘 | Ana p Mario V Rogerio B | 2010 | J Mater Sci Mater Med2010，21，8： | 1 |
| 20 | β-Glucosidase activity in wine yeasts: Application in enology显示文摘 | Maria A V Juan F uI Ana I B P | 2007 | Enzyme and Microbial Technology2007，40，3： | 1 |
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