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| 1 | Stem cell therapy in inflammatory bowel disease: A promising therapeutic strategy?显示文摘Inflammatory bowel diseases are inflammatory, chronic and progressive diseases of the intestinal tract for which no curative treatment is available. Research in other fields with stem cells of different sources and with immunoregulatory cells(regulatory T-lymphocytes and dendritic T-cells) opens up new expectations for their use in these diseases. The goal for stem cell-based therapy is to provide a permanent cure. To achieve this, it will be necessary to obtain a cellular product, original or genetically modified, that has a high migration capacity and homes into the intestine, has high survival after transplantation, regulates the immune reaction while not being visible to the patient's immune system, and repairs the injured tissue. | Ana I Flores Gonzalo J Gómez-Gómez ángeles Masedo-González M Pilar Martínez-Montiel | 2015 | World Journal of Stem Cells2015，7，2： | 7 |
| 2 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 3 | Appropriateness of outpatient gastrointestinal endoscopy in a non-academic hospital显示文摘AIM:To assess the appropriate use and the diagnostic yield of upper gastrointestinal endoscopy and colonoscopy in this subgroup of patients.METHODS:In total,789 consecutive outpatients referred for gastrointestinal(GI) endoscopy [381 for esophagogastroduodenoscopy(EGD) and 408 for colonoscopy] were prospectively enrolled in the study.The American Society for Gastrointestinal Endoscopy(ASGE) guidelines were used to assess the relationship between appropriateness and the presence of relevant endoscopic f indings.RESULTS:The overall inappropriate rate was 13.3%.The indications for EGD and colonoscopy were,respectively,appropriate in 82.7% and 82.6% of the exams,uncertain in 5.8% and 2.4% and inappropriate in 11.5% and 15%.The diagnostic yield was signif icant higher forEGDs and colonoscopies judged appropriate and uncertain when compared with those considered inappropriate(EGD:36.6% vs 36.4% vs 11.4%,P = 0.004;Colonoscopy:24.3% vs 20.0% vs 3.3%,P = 0.001).Of the 25 malignant lesions detected,all but one was detected in exams judged appropriate or uncertain.CONCLUSION:This study shows a good adherence to ASGE guidelines by the referring physicians and a significant increase of the diagnostic yield in appropriate examinations,namely in detecting neoplastic lesions.It underscores the importance that the appropriateness of the indication assumes in assuring high-quality GI endoscopic procedures. | Joo Mangualde Marie I Cremers Ana M Vieira Ricardo Freire lia Gamito Cristina Lobato Ana L Alves Fátima Augusto Ana P Oliveira | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，10： | 2 |
| 4 | Development of a PCR assay for Streptococcus iniae based on the lactate oxidase(lctO )gene with potential diagno- sticvalue显示文摘 | I ANA M MATA BLANCO MAR | 2004 | Veterinary Microbiology2004，101，： | 1 |
| 5 | Pyrroline-5-carboxylate synthase and proline biosynthesis :from osmotoleranee to rare met- abolic disease 显示文摘 | Isabel P A Francisco C A Ana I M | 2010 | Protein Sci2010，19，： | 1 |
| 6 | Antimicrobial susceptibility of clinical strains of Streptococcus suis isolated from pigs in Spain 显示文摘 | ANA I V MIGUEL A M JOSE A C | 2005 | Veterinary Microbiology2005，105，2： | 1 |
| 7 | Comparative study of UV/TiO2,UV/ZnO and photo-Fenton processes for the organic reactive dye degradation in aqueous solution显示文摘 | PETERNEL I T KOPRIVANAC N ANA M L | 2007 | Journal of Hazardous Materials2007，148，： | 1 |
| 8 | Influence of temperature, pH and ionic strength on the production of isoflavone - rich soy protein isolates 显示文摘 | ANA C L B FRANCO M L MARIA I G | 2006 | Food Chemistry2006，98，： | 1 |
| 9 | Nanofiltration of a clarified fermentation broth显示文摘 | Ana I Ana M Brites A | 2006 | Chemical Engineering Science2006，61，： | 1 |
| 10 | Studies on the interaction of emeraldine base polyaniline with Cu(Ⅱ), Fe(Ⅲ), and Zn(Ⅱ) ions in solutions and films显示文摘 | Celly M S I Ana M D C F Vera R L C | 2007 | Macromolecules2007，40，： | 1 |
| 11 | Ara bidopsis peroxisomal citrate synthase is required for fatty acid respi ration and seed germination显示文摘 | PRACHAROEN ATI'ANA I CORNAH J E SMITH S M | 2005 | The Plant Cell2005，17，20： | 1 |
| 12 | Glutathione-mediated cadmium sequestration in Rhizobium leguminosarum显示文摘 | Ana I G L Sofia C C Etelvina M A P F | 2006 | Enzyme and Microbial Technology2006，39，4： | 1 |
| 13 | Fast electrochromic response of ultraporous polyaniline nanofibers显示文摘 | EUSTAQUIO M E ANA M B RODRIGO A I | 2014 | Polymer2014，55，10： | 1 |
| 14 | A discrete simulation anal- ysis of a logistics supply system 显示文摘 | ANA D I REINALDO M | 2006 | Logistics and Transportation Review2006，42，3： | 1 |
| 15 | Rational selection of Leuconostoc strains for mixed starters based on the physiological biodiversity found in raw milk fermentations显示文摘 | Jorge I S Beatriz M Ana R | | 0，，： | 1 |
| 16 | Thermal and mass spectroscopic characterization of a sulphur-containing bacterial melanin from Bacillus subtilis显示文摘 | Ana M Gomez M Carlos I | 2010 | Journal of Non-Crystalline Solids2010，，356： | 1 |
| 17 | Antimicrobial susceptibility of clinical strains of Streptococcus suis isolated from pigs in Spain显示文摘 | Ana I V Miguel A M Jose A C | 2005 | Veterinary Microbiology2005，2，105： | 1 |
| 18 | 显示文摘 | Ana I R N A B Artur M S S | 2003 | Tetrahedron Letters2003，44，： | 1 |
| 19 | Maternal effect and familial aggregation in a type 2 diabetic Moroccan population显示文摘 | Benrahma H Ana I Charif M et ol | 2011 | J Community Health2011，36，6： | 1 |
| 20 | Palladium( II ) and plati- num ( II ) bis (thiosemicarbazone) complexes of the 2, 6-diacetylpyridine series with high cytotoxic activity in cisplatin resistant A2780cisR tumor ceils and reduced toxicity 显示文摘 | Ana I M Ines L Pilar S | 2013 | J Inorg Biochem2013，125，： | 1 |
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