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| 1 | Noncontrast-enhanced MRI-based Noninvasive Score for Portal Hypertension(CHESS1802):An International Multicenter Study显示文摘Background and Aims:This study aimed to determine the performance of the non-invasive score using noncontrastenhanced MRI(CHESS-DIS score)for detecting portal hy-pertension in cirrhosis.Methods:In this international multicenter,diagnostic study(ClinicalTrials.gov,NCT03766880),patients with cirrhosis who had hepatic venous pressure gradient(HVPG)measurement and noncontrast-enhanced MRI were prospectively recruited from four university hospitals in China(n=4)and Turkey(n=1)between December 2018 and April 2019.A cohort of patients was retrospectively recruited from a university hospital in Italy between March 2015 and November 2017.After segmentation of the liver on fat-suppressed T1-weighted MRI maps,CHESS-DIS score was calculated automatically by an in-house developed code based on the quantification of liver surface nodularity.Results:A total of 149 patients were included,of which 124 were from four Chinese hospitals(training cohort)and 25 were from two international hospitals(validation cohort).A positive correlation between CHESS-DIS score and HVPG was found with the correlation coefficients of 0.36(p<0.0001)and 0.55(p<0.01)for the training and validation cohorts,respectively.The area under the receiver operating characteristic curve of CHESS-DIS score in detection of clinically significant portal hypertension(CSPH)was 0.81 and 0.9 in the training and validation cohorts,respectively.The intra-class correlation coefficients for assessing the inter-and intra-observer agreement were 0.846 and 0.841,respectively.Conclusions:A non-invasive score using noncontrast-enhanced MRI was developed and proved to be significantly correlated with invasive HVPG.Besides,this score could be used to detect CSPH in patients with cirrhosis. | Yanna Liu Tianyu Tang NecatiÖrmeci Yifei Huang Jitao Wang Xiaoguo Li Zhiwei Li Weimin An Dengxiang Liu Chunqing Zhang Changchun Liu Jinqiang Liu Chuan Liu Guangchuan Wang Cristina Mosconi Alberta Cappelli Antonio Bruno Seray Akçalar EmrecanÇelebioğlu EvrenÜstüner Sadık Bilgiç Zeynep Ellik ÖzgünÖmer Asiller Lei Li Haijun Zhang Ning Kang Dan Xu Ruiling He Yan Wang Yang Bu Ye Gu Shenghong Ju Rita Golfieri Xiaolong Qi | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 3 |
| 2 | Hyperh exos emia induced fu ncti onal and s tructural changes in th e kidneys:role of endoth elins显示文摘 | Chen S EV AN ST Deng D | 2002 | Nephron2002，90，： | 1 |
| 3 | Refractory Kawasaki disease显示文摘 | Freem an AF Shulman ST | 2004 | Pediatr Infect Dis J2004，23，5： | 1 |
| 4 | Study of interactions between DNA-ethidium bromide (EB) and DNA-acridine orange (AO), in solution, using hanging mercury drop electrode (HMDE) 显示文摘 | Gherghi 1Ch Girousi ST Voulgaropoulos AN Gherghi ICh Girousi ST Voulgaropoulos AN | 2003 | Talanta2003，61，2： | 1 |
| 5 | Necrotic and apoptotic myocyte cell death in the aging heart of fischer 344 rats显示文摘 | Kaj st ura J Cheng W Sarangaraj an R | 1996 | Am J Physiol1996，271，： | 1 |
| 6 | Effects of the total flavonoid extract of Xiaobuxin-Tang on depression-like behavior induced by lipopolysaccharide and proinflammatory cytokine levels in mice显示文摘 | An L Li J Yu ST | 2015 | J Ethnopharmacol2015，，163： | 1 |
| 7 | Expansion in size of a terminal deletion:a paradigm shift for parental follow-up studies 显示文摘 | South ST Rope AF Lamb AN | 2008 | J Med Genet2008，45，6： | 1 |
| 8 | Safety of adeno - associated vires as cochlear gene transfer vector: analysis of distant spread beyond injected cochleae显示文摘 | Kho ST Pettis RM Mhatre AN | 2000 | Mol Ther2000，2，4： | 1 |
| 9 | Stenosing ureter- itis in a 7-year-old boy with Henoch-Schonlein purpura ne- phritis:A case report and review of the literature显示文摘 | Corbett ST Lennington JN Chua AN | 2010 | J Pediatr Urol2010，6，6： | 1 |
| 10 | Endothelial-derived PDGF-BB and HB-EGF coordinatelyregulate pericyte recruitment during vasculogenic tube assemblyand stabilization显示文摘 | St r a tma n AN Sc hwi n d t AE Ma l o t t e KM Da v i s GE | 2010 | Blood2010，116，22： | 1 |
| 11 | Cureumin potentiates the antitumor effects of gemcitatfine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers 显示文摘 | Tharak an ST I namoto T Sung B Aggar wal BB | 2010 | Biochem Pharmaco12010，79，： | 1 |
| 12 | Material characterization of glass / polypropylene composite bone plates according to the forming condition and performance evaluation under a simulated human body environment显示文摘 | Park SW Yoo SH An ST | 2012 | Composites2012，43，： | 1 |
| 13 | Stenosing ureteritis in a 7-year-old boy with Henoch-Schtmlein purpura nephritis: A case report and review of the literature 显示文摘 | Corbett ST Lennington JN Chua AN | 2010 | J Pediatr Urol2010，6，6： | 1 |
| 14 | Preventable and non‐preventable risk factors for influenza transmission and hygiene behavior in German influenza households, pandemic season (H1N1) 2009/2010显示文摘 | Cornelius Remschmidt Petra St?cker Matthias an der Heiden Thorsten Suess Monika Luchtenberg Susanne B. Schink Brunhilde Schweiger Walter Haas Udo Buchholz | 2012 | Influenza and Other Respiratory Viruses2012，，3： | 1 |
| 15 | Effect of total flavonoid extract of Xiaobuxin- Tang on depression-like behavior induced by lipopolysaccharide and pminflammatory cytokine levels in mice 显示文摘 | An L Li J Yu ST | 2015 | J Ethnopharmacol2015，163，： | 1 |
| 16 | Oxidative DHA damage and alteration of glutamate transporter expressions in the hippocampal CAI显示文摘 | An ST Kang TC Park SK | 2002 | Mol Cell2002，13，3： | 1 |
| 17 | Cochlear microinjection and its effects upon auditory function in the guinea pig 显示文摘 | Kho ST Pettis RM Mhatre AN | 2000 | Eur Arch Otorhinolaryngol2000，257，9： | 1 |
| 18 | Type 2 innate lymphoid cells: new players in asthma and allergy显示文摘 | Scanlon ST McKenzie AN | 2012 | Curr Opin Immunol2012，24，6： | 1 |
| 19 | Glucose and Glutamine Metabolism Regulate Human Hematopoietic Stem Cell Lineage Specification显示文摘 | Leal Oburoglu Saverio Tardito Vanessa Fritz Stéphanie C. de Barros Peggy Merida Marco Craveiro Jo?o Mamede Gaspard Cretenet Cédric Mongellaz Xiuli An Dorota Klysz Jawida Touhami Myriam Boyer-Clavel Jean-Luc Battini Valérie Dardalhon Valérie S. Zimmermann | 2014 | Cell Stem Cell2014，，5： | 1 |
| 20 | Oxidative DHA damage and alteration of glutamate transporter expressions in the hippocampal CA1 显示文摘 | An ST Kang TC Park SK | 2002 | Mol Cell2002，13，3： | 1 |
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